Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTSRI6)

Drug Name

Oprelvekin Drug Info

Synonyms

Neumega; Neumega (TN); Oprelvekin (genetical recombination); Oprelvekin (USAN/INN); Oprelvekin (genetical recombination) (JAN)

Indication

Disease Entry	ICD 11	Status	REF
Inflammatory bowel disease	DD72	Approved	[1]
MALT lymphoma		Approved	[2]
Nodal marginal zone lymphoma	2A85.0	Approved	[2]
Splenic marginal zone lymphoma		Approved	[2]
Thrombocytopenia	3B64	Approved	[3]
Ulcerative colitis	DD71	Approved	[2]

Therapeutic Class

Anticoagulants

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Interleukin 11 receptor alpha (IL11RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
UNI-rhIL-11	DM0DIEZ	Thrombocytopenia	3B64	Phase 3	[5]
BMTP-11	DMB6FMH	Prostate cancer	2C82.0	Phase 1	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin 11 receptor alpha (IL11RA)	TTZPLJS	I11RA_HUMAN	Binder	[4]

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References

1	Interleukin-11. BioDrugs. 1997 Dec;8(6):418-29.
2	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6971).
4	Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs. 1998 Aug;10(2):159-71.
5	Clinical study of rhIL-11 for prevention and treatment of chemotherapy-induced thrombocytopenia. Ai Zheng. 2002 Aug;21(8):892-5.
6	Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens. Clin Cancer Res. 2015 Jul 1;21(13):3041-51.