Details of the Drug

General Information of Drug (ID: DMUKBI2)

Drug Name

mRNA-2752

Synonyms

mRNA-OX40L/IL-23/IL-36 gamma

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
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Drug Type

mRNA therapy

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-23 (IL23)	TTC1GLB	IL23A_HUMAN	Replacement	[2]
Interleukin-36 gamma (IL36G)	TT8SLDN	IL36G_HUMAN	Replacement	[2]
TAX transcriptionally-activated glycoprotein 1 (OX40)	TTBW580	TNFL4_HUMAN	Replacement	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Solid tumour/cancer

ICD Disease Classification

2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Interleukin-23 (IL23)	DTT	IL23A	5.37E-01	-0.1	-0.42

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT03739931) Dose Escalation Study of mRNA-2752 for Intratumoral Injection to Participants With Advanced Malignancies. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Moderna Therapeutics.