Details of the Drug

General Information of Drug (ID: DMUWBIJ)

Drug Name
Propiverine
Synonyms
propiverine hydrochloride; 54556-98-8; Propiverine HCl; Mictonorm; Propiverine Hydrochlorride; UNII-DC4GZD10H3; (1-methylpiperidin-4-yl) 2,2-diphenyl-2-propoxyacetate hydrochloride; DSSTox_RID_81957; DSSTox_CID_26847; DSSTox_GSID_46847; C23H29NO3.HCl; DC4GZD10H3; CAS-54556-98-8; NCGC00181103-01; Mictonetten; Pollarine; Mictonorm (TN); propiverin hydrochloride; Bup-4 (TN); AC1L9B4A; CHEBI:8494; SCHEMBL1034248; DTXSID1046847; CHEMBL2359059; Propiverine hydrochloride (JP17); KFUJMHHNLGCTIJ-UHFFFAOYSA-N; BCP09576; Tox21_112719; NSC172140
Indication
Disease Entry ICD 11 Status REF
Urinary incontinence MF50.2 Approved [1]
Affected Organisms
Humans and other mammals
ATC Code
G04BD06: Propiverine
G04BD: Drugs for urinary frequency and incontinence
G04B: UROLOGICALS
G04: UROLOGICALS
G: GENITO URINARY SYSTEM AND SEX HORMONES
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 367.5
Logarithm of the Partition Coefficient (xlogp) 4.7
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 16 mcgh/L [2]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 8.2 mcg/L [2]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1 h [2]
Bioavailability
The bioavailability of drug is 6% [2]
Clearance
The total clearance of drug is 371 mL/min [3]
Elimination
60% radioactivity was recovered in urine and 21% was recovered in feces within 12 days, and less than 1% of an oral dose is excreted unchanged in the urine [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 22.1 hours [3]
Metabolism
The drug is metabolized via the liver [4]
Unbound Fraction
The unbound fraction of drug in plasma is 0.1% [5]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 2.73 L/kg [5]
Chemical Identifiers
Formula
C23H29NO3
IUPAC Name
(1-methylpiperidin-4-yl) 2,2-diphenyl-2-propoxyacetate
Canonical SMILES
CCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OC3CCN(CC3)C
InChI
InChI=1S/C23H29NO3/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21/h4-13,21H,3,14-18H2,1-2H3
InChIKey
QPCVHQBVMYCJOM-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4942
ChEBI ID
CHEMBL1078261
CAS Number
60569-19-9
UNII
468GE2241L
DrugBank ID
DB12278
TTD ID
D0TV9K
INTEDE ID
DR1363
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Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor M5 (CHRM5) TTH18TF ACM5_HUMAN Antagonist [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [7]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Ditropan XL FDA label
3 Mictoryl monograph
4 Pharmacokinetic Studies on Propiverine Hydrochloride
5 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
6 Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. Life Sci. 1999;64(25):2351-8.
7 Product monograph: Mictoryl (Propiverine hydrochloride modified-release capsules).