Details of the Drug

General Information of Drug (ID: DMW9MOK)

Drug Name
Lomeguatrib
Synonyms Patrin; AZD-5896; Patrin-2; O6-(4-bromothenylguanine), Cancer Research UK/KuDOS; 4-BTG (cancer), Paterson/Trinity/CRC/KuDOS/AstraZeneca
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 326.17
Logarithm of the Partition Coefficient (xlogp) 2
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C10H8BrN5OS
IUPAC Name
6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine
Canonical SMILES
C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N
InChI
InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
InChIKey
JUJPKFNFCWJBCX-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
3025944
CAS Number
192441-08-0
TTD ID
D0B2WQ
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Transferase unspecific (TF) TTX2N1T NOUNIPROTAC Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 147 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 5.5169 8.1175 4.541 7.4169
JK1 CTRP2 5.6386 8.6318 4.3987 7.7426
JM1 CTRP2 5.0622 10.2574 3.0722 14.4863
EoL-1 CTRP2 2.6854 4.3218 2.6692 22.4326
MOLM-16 CTRP2 3.8194 5.7016 3.7004 15.2333
Pfeiffer CTRP2 3.8292 6.7509 3.4028 16.2914
697 CTRP2 4.2777 9.7355 2.5783 18.3009
A4/Fukuda CTRP2 4.3832 6.9332 3.9298 12.7238
MV4-11 CTRP2 4.4144 5.9239 4.2969 11.2675
Mono-Mac-1 CTRP2 4.5473 6.3069 4.332 10.7391
KMS-12-BM CTRP2 4.6198 6.2068 4.4425 10.1175
Peer CTRP2 4.634 6.0941 4.4914 9.8966
Kasumi-1 CTRP2 4.6817 8.5056 3.5518 13.4382
MOLT-16 CTRP2 4.748 6.3318 4.5419 9.3723
HH [Human lymphoma] CTRP2 4.7548 8.3869 3.6793 12.7438
SUP-T1 CTRP2 4.7846 8.8494 3.491 13.4331
NU-DUL-1 CTRP2 4.8178 6.5886 4.5258 9.232
KE-37 CTRP2 4.9011 6.1316 4.7718 8.0724
Ri-1 CTRP2 4.9133 7.9636 4.0329 10.925
KMS-26 CTRP2 4.9298 6.9611 4.4959 9.0389
DB CTRP2 4.934 8.0923 3.9936 11.033
KMS-34 CTRP2 4.936 6.0336 4.8377 7.7277
Ki-JK CTRP2 4.9667 7.2431 4.4128 9.2686
GA-10 CTRP2 4.9687 8.0958 4.0261 10.8165
MOLT-13 CTRP2 5.0216 6.5485 4.7591 7.7706
KM-H2 CTRP2 5.045 7.1005 4.5556 8.4991
EB1 CTRP2 5.0738 7.709 4.3101 9.4085
ST486 CTRP2 5.0918 9.6204 3.4115 13.0393
KMS-20 CTRP2 5.127 6.9526 4.7045 7.6963
KMS-21-BM CTRP2 5.1373 7.0384 4.6777 7.775
JVM-3 CTRP2 5.1559 6.9511 4.7349 7.5005
PL21 CTRP2 5.157 7.69 4.4012 8.835
THP-1 CTRP2 5.162 6.8284 4.7939 7.2523
KHM-1B CTRP2 5.1833 7.7959 4.3774 8.8676
OCI-AML-2 CTRP2 5.2106 6.269 5.0645 6.0785
TALL-1 [Human adult T-ALL] CTRP2 5.2218 7.0425 4.7623 7.2203
BDCM CTRP2 5.2279 11.1124 2.8015 15.2047
NALM-6 CTRP2 5.2286 7.0078 4.7846 7.1143
SIG-M5 CTRP2 5.2439 8.7318 3.9866 10.3282
RS4;11 CTRP2 5.2521 8.1329 4.2838 9.0862
RPMI-8226 CTRP2 5.2583 6.4638 5.0442 6.0193
Karpas-299 CTRP2 5.262 6.7651 4.9248 6.4727
Ku812 CTRP2 5.2849 8.4092 4.1817 9.43
Daudi CTRP2 5.2871 7.7922 4.4802 8.1989
MM1.S CTRP2 5.2922 7.1265 4.7959 6.9066
SET-2 CTRP2 5.3129 11.9868 2.4435 16.4265
SKM-1 CTRP2 5.3154 6.3987 5.1302 5.5313
SUP-HD1 CTRP2 5.3155 11.6688 2.6038 15.7958
HDLM-2 CTRP2 5.3244 8.0907 4.3731 8.5505
LP-1 CTRP2 5.3325 11.821 2.5433 15.9961
SU-DHL-8 CTRP2 5.3365 6.9479 4.9212 6.2928
MOLT-3 CTRP2 5.3533 7.712 4.5824 7.6235
SU-DHL-6 CTRP2 5.377 7.0145 4.932 6.1466
Karpas-422 CTRP2 5.3789 10.6556 3.1631 13.4193
KE-97 CTRP2 5.3993 6.9385 4.989 5.8617
SUP-M2 CTRP2 5.4155 6.8822 5.0307 5.6538
K-562 CTRP2 5.4212 9.799 3.6254 11.4288
OCI-Ly19 CTRP2 5.428 8.6651 4.1906 9.0692
RPMI-8402 CTRP2 5.4427 6.8601 5.0683 5.4344
A3/Kawakami CTRP2 5.4447 6.6827 5.1491 5.1074
GDM-1 CTRP2 5.4497 6.9522 5.0334 5.5568
F-36P CTRP2 5.4581 7.7137 4.682 6.9685
BV-173 CTRP2 5.4598 7.0031 5.0201 5.5846
L-428 CTRP2 5.4626 8.7469 4.1822 9.0274
Hs 611.T CTRP2 5.4661 7.5048 4.79 6.5061
Namalwa CTRP2 5.4726 10.0461 3.5491 11.6336
KYO-1 CTRP2 5.473 6.8864 5.0868 5.2835
P31/FUJ CTRP2 5.4833 7.5603 4.7798 6.5077
SUP-T11 CTRP2 5.4998 6.6345 5.2268 4.6563
OCI-AML-3 CTRP2 5.5054 7.5302 4.8154 6.31
BL-70 CTRP2 5.5124 6.0313 5.4673 3.7014
KMS-18 CTRP2 5.5253 7.0844 5.047 5.3151
Jurkat CTRP2 5.5581 6.9368 5.1483 4.8238
MOLM-13 CTRP2 5.5667 6.9696 5.1415 4.8305
KMS-11 CTRP2 5.5714 7.147 5.0622 5.1426
SU-DHL-1 CTRP2 5.581 6.488 5.374 3.8622
Mino CTRP2 5.5853 6.8399 5.2203 4.4652
L-540 CTRP2 5.5938 7.481 4.923 5.6619
OCI-Ly10 CTRP2 5.5946 11.0798 3.1427 13.0452
JURL-MK1 CTRP2 5.5981 7.4713 4.9318 5.6158
NOMO-1 CTRP2 5.6093 8.2522 4.5598 7.1344
Kasumi-2 CTRP2 5.636 7.3087 5.0464 5.0559
KO52 CTRP2 5.6472 9.5591 3.9459 9.6153
OCI-Ly3 CTRP2 5.6536 7.5371 4.9517 5.4075
NCI-H929 CTRP2 5.6555 7.4277 5.0068 5.1749
MOTN-1 CTRP2 5.6564 8.824 4.3193 8.0361
CMK CTRP2 5.6629 6.4467 5.4765 3.2426
SUP-B15 CTRP2 5.6872 7.8692 4.8195 5.8822
PF-382 CTRP2 5.6904 7.982 4.7668 6.0948
WSU-DLCL2 CTRP2 5.7099 6.6693 5.4228 3.3391
NCO2 CTRP2 5.7434 7.2722 5.1646 4.3233
MOLP-8 CTRP2 5.7565 7.1137 5.2542 3.9222
JeKo-1 CTRP2 5.765 9.0901 4.2829 7.9612
M-07e CTRP2 5.7842 7.6914 4.9951 4.9397
SK-MM-2 CTRP2 5.843 7.7164 5.0352 4.6477
RCH-ACV CTRP2 5.8654 8.0828 4.8725 5.2826
NB4 CTRP2 5.8667 7.2708 5.2774 3.5841
TF-1 CTRP2 5.8713 6.5366 5.6425 2.0562
DEL CTRP2 5.8783 7.399 5.2241 3.7824
OCI-M1 CTRP2 5.879 6.8762 5.4837 2.6965
HPB-ALL CTRP2 5.8806 7.782 5.0356 4.5673
HD-MY-Z CTRP2 5.8924 10.128 3.8746 9.4121
EM-2 CTRP2 5.9043 7.9112 4.9918 4.7024
RL CTRP2 5.9049 6.5509 5.6672 1.8769
SR CTRP2 5.9082 7.143 5.3778 3.0764
HuNS1 CTRP2 5.9241 7.3138 5.3069 3.3402
Granta-519 CTRP2 5.9272 9.6132 4.1614 8.1426
NU-DHL-1 CTRP2 5.9273 7.5249 5.2045 3.7633
RPMI-6666 CTRP2 5.9505 7.7695 5.1024 4.1443
SU-DHL-10 CTRP2 5.961 6.6705 5.6594 1.787
HEL CTRP2 5.9665 6.7801 5.6097 1.9831
KMM-1 CTRP2 5.967 9.7519 4.1257 8.2135
EJM CTRP2 5.9711 8.2134 4.8982 4.9612
Reh CTRP2 5.9755 7.666 5.1755 3.7874
JJN-3 CTRP2 5.9839 8.4909 4.7704 5.4728
KMS-27 CTRP2 5.9982 8.8942 4.5808 6.2418
LAMA-84 CTRP2 6.0117 7.4501 5.3141 3.1333
U266B1 CTRP2 6.0264 7.8651 5.119 3.9248
CML-T1 CTRP2 6.0315 7.3262 5.3927 2.7644
MOLM-6 CTRP2 6.0326 8.3455 4.884 4.9001
P12-Ichikawa CTRP2 6.0374 8.9635 4.579 6.173
AML-193 CTRP2 6.0629 7.3146 5.4246 2.5695
MHH-CALL-3 CTRP2 6.0637 8.2697 4.9478 4.5721
KCL-22 CTRP2 6.0689 7.6538 5.26 3.2501
U-937 CTRP2 6.0763 8.1328 5.0267 4.2165
L-363 CTRP2 6.0965 6.9657 5.6264 1.6592
EHEB CTRP2 6.1214 8.7453 4.7576 5.262
HT CTRP2 6.1446 7.9734 5.1621 3.5198
CA46 CTRP2 6.1518 13.5809 2.3653 15.0023
SU-DHL-4 CTRP2 6.1932 7.9641 5.2056 3.2491
HL-60 CTRP2 6.2239 10.1285 4.1499 7.6213
MHH-CALL-4 CTRP2 6.229 7.8162 5.3072 2.7602
HuT 78 CTRP2 6.2681 8.2243 5.1348 3.4127
MC116 CTRP2 6.2998 7.2552 5.6364 1.2803
DND-41 CTRP2 6.3618 8.9022 4.8706 4.3543
Karpas-620 CTRP2 6.3868 8.0311 5.3199 2.4447
Raji CTRP2 6.4161 8.04 5.3368 2.329
REC-1 CTRP2 6.562 12.2453 3.3641 10.2637
MOLP-2 CTRP2 6.7235 8.6191 5.2695 2.156
ME1 CTRP2 6.8008 9.2057 5.041 2.9617
Ci-1 CTRP2 7.0697 7.8919 5.7731 0.1559
P3HR-1 CTRP2 7.0732 8.6604 5.4616 1.0379
AMO1 CTRP2 7.6042 9.1042 5.5373 0.4409
OPM-2 CTRP2 8.0354 22.0676 -0.3744 20.503
OCI-AML-5 CTRP2 9.9787 19.6664 2.1666 9.6893
HEL 92.1.7 CTRP2 11.3948 24.384 0.8578 12.1406
Toledo CTRP2 11.7785 32.3582 -2.6944 20.5643
⏷ Show the Full List of 147 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 5.5686 8.6995 4.3021 8.2962
TE8 CTRP2 5.819 10.78 3.4863 11.1743
TE-6 CTRP2 5.3239 6.8941 4.3409 2.6351
TE-11 CTRP2 5.6888 9.0878 4.2171 8.3951
TE-4 CTRP2 5.7165 8.0069 4.7781 5.9914
KYSE-70 CTRP2 5.7462 7.7504 4.9317 5.2865
EC-GI-10 CTRP2 5.9311 12.0042 2.9695 13.0613
OE21 CTRP2 5.9326 9.1517 4.3967 7.1444
TE-5 CTRP2 6.054 17.1282 0.5105 21.5787
KYSE-520 CTRP2 6.1464 8.3616 4.9697 4.3244
TE-10 CTRP2 6.1947 8.421 4.9789 4.1967
TE-1 CTRP2 6.2462 9.2945 4.5843 5.7587
KYSE-410 CTRP2 6.3039 9.0286 4.7626 4.9074
KYSE-140 CTRP2 6.3283 14.4173 2.0921 15.6909
TE-14 CTRP2 6.3842 8.0671 5.3003 2.5296
KYSE-180 CTRP2 6.462 8.4864 5.1515 3.0198
OE33 CTRP2 6.5799 9.381 4.7986 4.289
TE-9 CTRP2 6.7337 9.8518 4.6801 4.5332
OE19 CTRP2 6.83 9.3731 4.9806 3.1634
KYSE-450 CTRP2 6.8398 12.6593 3.3742 9.7341
KYSE-30 CTRP2 6.8526 8.8113 5.2625 2.0146
COLO 680N CTRP2 6.9066 10.993 4.2467 6.0435
KYSE-150 CTRP2 6.9446 8.7627 5.342 1.6007
KYSE-510 CTRP2 7.1514 10.0891 4.8535 3.229
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 6.1145 7.4591 5.3945 2.5994
Panc 02.03 CTRP2 0.4727 2.6996 -2.6916 1.2713
HuP-T4 CTRP2 4.5876 8.7867 3.3278 14.5706
BxPC-3 CTRP2 5.0222 12.4028 1.9777 18.8298
PaTu 8988s CTRP2 5.3492 35.3569 -9.1951 38.0674
KP-3 CTRP2 5.8025 8.7702 4.475 7.0787
PSN1 CTRP2 5.9085 9.106 4.3989 7.1831
MIA PaCa-2 CTRP2 6.0051 8.4591 4.8041 5.2896
DAN-G CTRP2 6.0078 6.8725 5.5994 1.9422
SNU-213 CTRP2 6.1794 8.7669 4.7939 5.0014
Hs 766T CTRP2 6.2384 7.7326 5.356 2.5401
SW1990 CTRP2 6.2397 7.6752 5.3855 2.415
PaTu 8988t CTRP2 6.2663 7.8677 5.3104 2.6824
Panc 03.27 CTRP2 6.2858 8.6498 4.937 4.2094
SUIT-2 CTRP2 6.295 7.5637 5.4821 1.9214
Capan-1 CTRP2 6.3625 7.8486 5.3917 2.1872
HPAC CTRP2 6.3935 8.923 4.8847 4.2409
PK-59 CTRP2 6.4287 10.2857 4.2349 6.8942
SNU-410 CTRP2 6.4528 8.7227 5.0285 3.5438
KP-4 CTRP2 6.4784 9.5077 4.6598 5.0339
KP-2 CTRP2 6.5056 10.2186 4.3281 6.3706
QGP-1 CTRP2 6.5202 8.6698 5.104 3.1236
CFPAC-1 CTRP2 6.5396 9.3282 4.7947 4.3709
TCC-Pan2 CTRP2 6.5694 8.7181 5.1158 2.999
Panc 05.04 CTRP2 6.5784 9.7839 4.5989 5.1197
AsPC-1 CTRP2 6.6037 8.5059 5.2428 2.4306
YAPC CTRP2 6.6201 9.0225 5.0036 3.3808
Panc 04.03 CTRP2 6.6334 9.6816 4.6903 4.6508
Capan-2 CTRP2 6.7944 9.24 5.0202 3.0548
Panc 08.13 CTRP2 6.8623 9.107 5.1293 2.5244
L3.3 CTRP2 6.8742 10.6827 4.3752 5.5664
HPAF-II CTRP2 6.9582 11.22 4.173 6.2645
Panc 10.05 CTRP2 6.989 9.8658 4.852 3.4552
SU.86.86 CTRP2 7.1135 8.9021 5.3775 1.2915
PaTu 8902 CTRP2 7.1771 8.558 5.559 0.6391
HuP-T3 CTRP2 8.3504 9.9839 5.5125 0.2179
PK-45H CTRP2 9.4537 21.9282 0.7331 15.0938
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 5.97 9.0518 4.4783 6.7278
G-361 CTRP2 4.9606 6.2546 4.7982 7.7987
Hs 852.T CTRP2 5.1951 7.7015 4.4333 8.6116
COLO 792 CTRP2 5.5249 6.461 5.3272 4.1953
LOX-IMVI CTRP2 5.5428 9.4034 3.9305 9.9002
Hs 944.T CTRP2 5.5852 8.018 4.6529 6.8001
WM115 CTRP2 5.7652 7.6611 4.993 4.9895
WM1799 CTRP2 5.7736 8.2515 4.7078 6.1636
Hs 940.T CTRP2 5.8504 8.9183 4.4427 7.1162
IPC-298 CTRP2 5.9172 7.5195 5.1983 3.8098
MeWo CTRP2 5.9892 7.862 5.0892 4.1228
WM88 CTRP2 5.9969 16.6983 0.6778 21.1804
Mel JuSo CTRP2 6.0817 7.3346 5.4301 2.5111
WT2-iPS CTRP2 6.091 6.8287 5.6904 1.4006
Hs 294T CTRP2 6.0999 8.2924 4.9663 4.4254
RPMI-7951 CTRP2 6.1071 7.3423 5.4469 2.3931
Malme-3M CTRP2 6.1151 8.642 4.804 5.0788
Hs 895.T CTRP2 6.1177 7.1325 5.5602 1.8984
CJM [Human melanoma] CTRP2 6.1264 13.4126 2.4285 14.8095
WM266-4 CTRP2 6.1533 7.278 5.5159 2.0199
SK-MEL-24 CTRP2 6.1665 8.1463 5.0934 3.7681
K029AX CTRP2 6.1776 7.372 5.4881 2.0936
HMCB CTRP2 6.1779 7.4162 5.4663 2.1842
SK-MEL-1 CTRP2 6.1792 7.5409 5.4053 2.437
UACC-62 CTRP2 6.2119 8.4037 5.0013 4.0717
HT-144 CTRP2 6.2512 7.5159 5.4731 2.0306
Hs 934.T CTRP2 6.2519 7.8811 5.2928 2.7808
A101D CTRP2 6.2558 7.2923 5.5867 1.5524
RVH-421 CTRP2 6.2847 7.4069 5.5515 1.6514
SK-MEL-5 CTRP2 6.2851 7.7857 5.3653 2.4223
IGR-39 CTRP2 6.2953 7.7375 5.3967 2.2747
COLO 800 CTRP2 6.3874 7.9497 5.3603 2.2773
Hs 936.T CTRP2 6.4259 7.4188 5.6432 1.0767
A2058 CTRP2 6.463 7.8708 5.4521 1.7881
Hs 839.T CTRP2 6.4861 8.7027 5.063 3.3469
SK-MEL-31 CTRP2 6.4911 8.1212 5.3506 2.1586
WM793 CTRP2 6.4958 9.1976 4.8263 4.312
COLO 829 CTRP2 6.5073 8.4832 5.1859 2.8072
IGR-1 CTRP2 6.5249 9.3248 4.7854 4.4338
SK-MEL-3 CTRP2 6.5271 9.5558 4.6729 4.8975
Mel Ho CTRP2 6.5586 8.1771 5.3702 1.9817
MDA-MB-435S CTRP2 6.6434 9.6949 4.6911 4.6314
SK-MEL-30 CTRP2 6.7129 9.4797 4.847 3.88
Hs 688(A).T CTRP2 6.7249 9.3279 4.9294 3.5251
A-375 CTRP2 6.7519 13.9371 2.671 12.6941
IGR-37 CTRP2 6.8104 8.178 5.5281 1.0626
UACC-257 CTRP2 6.8119 10.7036 4.3194 5.8955
SK-MEL-28 CTRP2 7.1695 7.9595 5.7874 0.1025
SK-MEL-2 CTRP2 7.228 8.093 5.7619 0.1266
WM983B CTRP2 10.8189 22.7112 1.2747 11.5685
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 7.7384 42.5336 -10.8084 36.1112
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NH-6 CTRP2 5.1317 14.9085 0.8305 22.5216
Kelly CTRP2 5.1729 9.3099 3.6386 11.9234
SK-N-BE(2) CTRP2 5.5852 8.1442 4.5909 7.0576
KP-N-SI9s CTRP2 5.6737 7.6718 4.9043 5.5593
CHP-212 CTRP2 5.7913 7.3628 5.164 4.22
SK-N-FI CTRP2 5.9412 7.1911 5.3829 2.9862
SK-N-SH CTRP2 6.0725 9.9231 4.1285 7.997
IMR-32 CTRP2 6.1393 7.3669 5.4605 2.2773
SK-N-AS CTRP2 6.1612 7.6185 5.3524 2.6907
MHH-NB-11 CTRP2 6.1819 8.5485 4.905 4.5305
CHP-126 CTRP2 6.2188 9.8827 4.2686 7.1333
SK-N-DZ CTRP2 6.3381 8.6169 4.994 3.8798
NB1 CTRP2 6.4013 8.1295 5.2823 2.5769
KP-N-YN CTRP2 8.0469 9.7428 5.4811 0.3703
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 4.1328 7.2536 3.5375 14.9237
SNU-478 CTRP2 5.5018 7.5159 4.8189 6.3039
SNU-308 CTRP2 6.1636 8.1367 5.0958 3.763
HuH-28 CTRP2 6.2672 7.7086 5.3899 2.3497
SNU-869 CTRP2 6.4554 10.3811 4.2083 6.9578
HuCC-T1 CTRP2 6.5217 9.3026 4.794 4.4035
SNU-1196 CTRP2 6.6718 8.6594 5.2156 2.4427
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP2 5.4042 7.0708 4.9335 6.0722
A-673 CTRP2 5.7023 7.3227 5.1017 4.6764
SK-N-MC CTRP2 5.7329 6.4923 5.5274 2.86
Hs 888.T CTRP2 5.9877 10.1934 3.9224 9.0243
SK-ES-1 CTRP2 5.9967 8.727 4.6631 5.8986
HOS CTRP2 6.0467 7.655 5.241 3.3724
CAL-78 CTRP2 6.1448 8.2039 5.0472 4.0019
TC71 CTRP2 6.2109 8.611 4.897 4.5109
MHH-ES-1 CTRP2 6.2735 10.1426 4.183 7.3909
SaOS-2 CTRP2 6.3121 8.3627 5.1001 3.4817
Hs 822.T CTRP2 6.3466 8.9955 4.8125 4.6234
SJSA-1 CTRP2 6.5498 9.0947 4.9172 3.8474
G-292 clone A141B1 CTRP2 6.818 8.9177 5.19 2.3439
SW1353 CTRP2 7.541 14.0836 3.1936 9.3075
MG-63 CTRP2 9.7103 19.4912 2.0757 10.3477
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 73 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ZR-75-30 CTRP2 0.8286 2.6634 -2.5372 0.4223
Hs 578T CTRP2 4.6829 13.9947 0.8845 23.3625
UACC-812 CTRP2 5.307 9.0021 3.9136 10.4867
HCC2218 CTRP2 5.6333 7.3744 5.0119 5.2044
HCC1500 CTRP2 5.6877 6.8635 5.3096 3.8539
AU565 CTRP2 5.6897 7.2863 5.1077 4.68
MDA-MB-453 CTRP2 5.7687 7.5011 5.0752 4.639
DU4475 CTRP2 5.8089 8.8558 4.4379 7.2214
MDA-MB-468 CTRP2 5.8331 8.9273 4.4233 7.2329
HCC202 CTRP2 5.8635 11.3724 3.2282 12.1461
HCC1569 CTRP2 5.8795 8.2578 4.7974 5.5686
HCC1143 CTRP2 6.0015 8.545 4.7582 5.4895
KPL-1 CTRP2 6.0576 7.9017 5.1267 3.8321
MDA-MB-231 CTRP2 6.0843 8.9865 4.6065 5.9675
HMC-1-8 CTRP2 6.0944 7.1152 5.55 1.9836
CAL-51 CTRP2 6.1309 7.64 5.3175 2.8925
HCC1419 CTRP2 6.138 8.3785 4.9544 4.4044
HCC1428 CTRP2 6.1416 9.2651 4.5143 6.2458
SK-BR-3 CTRP2 6.1985 8.1845 5.0999 3.6825
BT-20 CTRP2 6.2298 8.2221 5.106 3.6009
HCC1395 CTRP2 6.2512 8.405 5.0317 3.8737
T-47D CTRP2 6.2971 8.9585 4.7922 4.7952
Hs 578Bst CTRP2 6.3379 10.032 4.2896 6.8275
BT-474 CTRP2 6.342 7.6629 5.4677 1.9063
HCC38 CTRP2 6.3519 9.6979 4.4672 6.0591
MCF-7 CTRP2 6.3898 8.1832 5.2474 2.7396
CAMA-1 CTRP2 6.4001 8.2717 5.2115 2.8715
CAL-148 CTRP2 6.4176 9.4427 4.6454 5.1982
MDA-MB-415 CTRP2 6.4318 9.6534 4.5517 5.5652
ZR-75-1 CTRP2 6.4322 8.9058 4.9226 4.0178
HCC1954 CTRP2 6.4684 8.5753 5.1126 3.1705
MDA-MB-361 CTRP2 6.5185 8.2558 5.3046 2.3051
JIMT-1 CTRP2 6.5248 9.0456 4.923 3.8637
CAL-120 CTRP2 6.7368 8.2839 5.4356 1.4906
HCC1806 CTRP2 6.774 10.5618 4.3611 5.7844
CAL-85-1 CTRP2 6.83 13.5845 2.9074 11.6259
BT-549 CTRP2 7.2302 16.1586 1.9383 14.6033
HDQ-P1 CTRP2 7.2805 12.8236 3.6217 8.0046
HCC1937 CTRP2 7.3921 12.0829 4.0612 6.0595
BT 231 CTRP2 6.1803 9.1146 4.6211 5.7253
BT 172 CTRP2 6.1953 8.0833 5.1478 3.4871
BT 482 CTRP2 6.2336 15.4178 1.5144 17.955
BT 428 CTRP2 6.2422 10.2527 4.1028 7.7845
BT 224 CTRP2 6.246 7.5548 5.4499 2.1358
BT164 CTRP2 6.261 9.0263 4.7299 5.1213
BT 112 CTRP2 6.3043 8.6983 4.9273 4.2171
BT 416 CTRP2 6.3198 8.8887 4.8447 4.5354
BT 330 CTRP2 6.3387 8.3382 5.1326 3.3007
BT 422 CTRP2 6.3393 7.713 5.4413 2.0194
BT 359 CTRP2 6.3486 7.581 5.5125 1.7125
BT 145 CTRP2 6.3561 10.7135 3.9643 8.1543
BT 320 CTRP2 6.5249 9.6806 4.6096 5.1646
BT 286 CTRP2 6.5396 8.2819 5.3066 2.2658
BT 271 CTRP2 6.5505 12.7571 3.1 11.3563
BT 232 CTRP2 6.573 8.7466 5.1045 3.04
BT 440 CTRP2 6.5842 7.8932 5.5218 1.3472
BT 504 CTRP2 6.6662 8.7749 5.1562 2.6904
BT 131 CTRP2 6.7742 10.1709 4.5533 4.9915
BT 245 CTRP2 6.8455 8.8208 5.2536 2.0585
BT 328 CTRP2 6.8803 9.4651 4.9705 3.1328
BT 444 CTRP2 6.8994 9.2225 5.099 2.595
BT 333 CTRP2 6.9541 9.13 5.1778 2.2154
BT 187 CTRP2 6.9587 10.3026 4.6207 4.4328
BT 498 CTRP2 7.0072 12.44 3.6093 8.4952
BT 228 CTRP2 7.0471 10.0503 4.8029 3.571
BT 159 CTRP2 7.0764 10.1229 4.7878 3.5905
BT 139 CTRP2 7.2721 10.9114 4.5424 4.2994
BT 239 CTRP2 7.3449 11.2533 4.4278 4.6557
BT 248 CTRP2 7.4336 15.8983 2.2218 13.2164
BT 216 CTRP2 7.4516 11.0402 4.5993 3.834
BT 179 CTRP2 7.5549 14.1607 3.1659 9.3949
BT147 CTRP2 8.189 16.7625 2.3504 11.526
BT 340 CTRP2 8.8506 15.1689 3.5548 6.0878
⏷ Show the Full List of 73 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 5.9743 7.703 5.156 3.8717
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-466 CTRP2 5.19 8.0803 4.2492 9.3745
KNS-60 CTRP2 5.4443 7.245 4.257 2.7997
D283 Med CTRP2 5.6673 8.0246 4.7248 6.32
GB-1 CTRP2 5.7745 7.8342 4.9157 5.2922
CAS-1 CTRP2 5.825 8.103 4.827 5.5568
SF268 CTRP2 5.847 7.4743 5.1589 4.1214
SF539 CTRP2 5.8633 8.0715 4.8763 5.2712
Hs 683 CTRP2 6.0473 6.9118 5.6131 1.8074
SNU-626 CTRP2 6.0526 8.5439 4.8015 5.2087
DK-MG CTRP2 6.0581 7.2735 5.4412 2.5092
SW1088 CTRP2 6.0697 8.3331 4.921 4.6734
A-172 CTRP2 6.0741 7.6414 5.2705 3.196
SNU-738 CTRP2 6.0892 8.5067 4.8503 4.9333
Becker CTRP2 6.1042 15.8846 1.174 19.3693
M059K CTRP2 6.1637 8.0862 5.1211 3.6566
LN-229 CTRP2 6.1646 8.8627 4.7341 5.2801
LN-18 CTRP2 6.1721 7.1124 5.6128 1.5822
SNU-489 CTRP2 6.1909 8.6306 4.8713 4.6555
42-MG-BA CTRP2 6.203 8.3191 5.0364 3.9406
CCF-STTG1 CTRP2 6.207 8.1355 5.1311 3.5365
U-118MG CTRP2 6.2244 7.3908 5.5147 1.9024
SNU-1105 CTRP2 6.2504 8.3525 5.0572 3.7686
SNU-201 CTRP2 6.2505 10.7947 3.8387 8.8724
YH-13 CTRP2 6.2505 15.2339 1.6202 17.5512
U-87MG ATCC CTRP2 6.2523 8.5444 4.9632 4.1591
YKG-1 CTRP2 6.2604 7.4159 5.5293 1.7823
ONS-76 CTRP2 6.2906 8.267 5.131 3.3898
TM-31 CTRP2 6.3474 8.5086 5.0548 3.6103
GMS-10 CTRP2 6.354 8.7534 4.9384 4.0845
KALS-1 CTRP2 6.3809 8.7366 4.9674 3.9177
GOS-3 CTRP2 6.3899 8.5763 5.0536 3.5436
DBTRG-05MG CTRP2 6.4477 9.3155 4.7316 4.7869
NMC-G1 CTRP2 6.4499 8.3237 5.2225 2.7466
SF295 CTRP2 6.4666 10.1517 4.3312 6.4254
KNS-81 CTRP2 6.4903 8.5693 5.1315 3.0575
KNS-42 CTRP2 6.5362 7.76 5.5536 1.2843
SF126 CTRP2 6.5614 8.508 5.2124 2.6166
8-MG-BA CTRP2 6.5989 10.1554 4.4307 5.7845
T98G CTRP2 6.6458 8.8416 5.1098 2.9085
Daoy CTRP2 6.6686 8.815 5.1385 2.7582
KG-1-C CTRP2 6.6782 9.6134 4.7566 4.3056
SNB-75 CTRP2 6.7966 11.4392 3.9453 7.4653
GaMG CTRP2 6.8383 9.73 4.814 3.8258
SW1783 CTRP2 6.8971 10.1943 4.63 4.4872
U-251MG CTRP2 6.9567 9.4916 5.009 2.8741
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-265 CTRP2 4.1277 6.9659 3.6446 14.5276
JHUEM-2 CTRP2 5.115 6.8804 4.7229 7.6557
JHUEM-7 CTRP2 5.3425 7.1187 4.8499 6.5633
HEC-1-B CTRP2 5.5777 8.1541 4.5791 7.1232
KLE CTRP2 5.6858 7.2305 5.1312 4.5917
RL95-2 CTRP2 5.6859 7.8955 4.8054 5.9437
HEC-151 CTRP2 5.7402 7.3065 5.1448 4.4125
JHUEM-1 CTRP2 5.7794 7.3465 5.1612 4.2575
JHUEM-3 CTRP2 5.9173 8.3525 4.7828 5.5536
HEC-50B CTRP2 6.0499 8.0491 5.0466 4.1834
AN3-CA CTRP2 6.084 10.2564 3.9713 8.6332
HEC-251 CTRP2 6.1104 8.3146 4.9638 4.4165
HEC-6 CTRP2 6.2464 8.198 5.131 3.4667
HEC-59 CTRP2 6.2844 8.176 5.1714 3.2316
HEC-1-A CTRP2 6.3322 8.3581 5.1177 3.3738
ESS-1 CTRP2 6.4231 10.7444 4.0021 7.8757
EFE-184 CTRP2 6.5029 9.3863 4.7385 4.6653
MFE-296 CTRP2 6.5793 8.7359 5.1141 2.9907
MFE-319 CTRP2 6.5852 9.3921 4.7971 4.2868
HEC-108 CTRP2 7.7716 11.2844 4.6856 3.1129
EN CTRP2 7.8228 14.0768 3.3964 8.0785
Ishikawa (Heraklio) 02 ER- CTRP2 6.2509 7.6068 5.4279 2.2188
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-54 CTRP2 5.6882 7.1919 5.1522 4.4995
ACHN CTRP2 6.0347 12.4054 2.8558 13.3126
TUHR4TKB CTRP2 6.1438 9.2521 4.5226 6.207
786-O CTRP2 6.1561 12.2943 3.012 12.4494
KMRC-1 CTRP2 6.1713 8.9964 4.6728 5.525
OS-RC-2 CTRP2 6.2286 8.9488 4.7427 5.126
VMRC-RCZ CTRP2 6.3074 11.1575 3.7036 9.3286
KMRC-20 CTRP2 6.3422 8.4861 5.062 3.589
TUHR10TKB CTRP2 6.3792 8.351 5.1568 3.1323
VMRC-RCW CTRP2 6.4204 9.6968 4.5213 5.7119
769-P CTRP2 6.4389 8.192 5.279 2.5312
TUHR14TKB CTRP2 6.4635 11.4561 3.6794 9.1442
BFTC-909 CTRP2 6.5905 8.3598 5.3041 2.2021
Caki-1 CTRP2 6.6305 17.6727 0.7112 19.8413
SNU-1272 CTRP2 6.9001 10.7246 4.3735 5.5328
A-498 CTRP2 6.9993 8.654 5.4233 1.2441
RCC10RGB CTRP2 7.1786 9.7938 5.0095 2.5862
KMRC-2 CTRP2 7.3851 13.6549 3.2904 9.1692
Caki-2 CTRP2 8.1206 19.3001 1.0572 16.1208
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LoVo CTRP2 4.1493 7.8003 3.328 15.692
GP2d CTRP2 4.4112 9.6298 2.7583 17.2691
CCK-81 CTRP2 5.1716 7.2629 4.6124 7.947
HCT 15 CTRP2 5.2034 7.7476 4.4199 8.6461
SNU-C1 CTRP2 5.3111 11.9463 2.4621 16.3581
SW1417 CTRP2 5.3166 21.4501 -2.2731 29.855
SNU-C5 CTRP2 5.3751 7.8229 4.5503 7.7036
CW-2 CTRP2 5.4261 9.4 3.8271 10.5823
SNU-61 CTRP2 5.4295 9.2384 3.9099 10.231
HT115 CTRP2 5.4486 7.5407 4.756 6.6867
SW48 CTRP2 5.5407 7.0232 5.0908 5.0995
SW1116 CTRP2 5.5868 8.4683 4.4327 7.7126
SNU-407 CTRP2 5.6275 9.0139 4.1994 8.5985
COLO 320 CTRP2 5.7306 9.4438 4.0766 8.8958
MDST8 CTRP2 5.7577 7.2439 5.1916 4.1791
SW620 CTRP2 5.7595 7.2627 5.1842 4.2061
C2BBe1 CTRP2 5.8657 9.045 4.3927 7.2951
T84 CTRP2 5.9998 7.3025 5.3778 2.889
RCM-1 [Human ESC] CTRP2 6.0767 7.0589 5.5638 1.9587
NCI-H508 CTRP2 6.112 8.1661 5.0394 4.0958
COLO 678 CTRP2 6.1154 16.8062 0.7225 20.804
RKO CTRP2 6.1529 8.7068 4.8024 5.0147
HT-55 CTRP2 6.1802 7.7194 5.3173 2.8041
LS123 CTRP2 6.2303 7.634 5.3987 2.3759
SW948 CTRP2 6.2316 7.4208 5.5053 1.9292
NCI-H747 CTRP2 6.2709 8.7155 4.8926 4.4215
COLO205 CTRP2 6.3079 7.4115 5.5661 1.5554
OUMS-23 CTRP2 6.3227 7.842 5.3657 2.3587
DLD-1 CTRP2 6.3517 8.9952 4.8166 4.5972
CL-11 CTRP2 6.4233 9.1061 4.8167 4.474
KM12 CTRP2 6.4456 10.1096 4.3357 6.4432
COLO201 CTRP2 6.4836 8.6711 5.0767 3.2943
HCC-56 CTRP2 6.5003 7.6135 5.5995 1.1516
LS1034 CTRP2 6.506 9.117 4.8738 4.0983
SNU-503 CTRP2 6.5429 8.6604 5.125 3.0021
LS513 CTRP2 6.5631 8.638 5.1504 2.8671
SK-CO-1 CTRP2 6.6148 8.6209 5.1949 2.6083
HCT 8 CTRP2 6.6293 8.9241 5.058 3.1441
SNU-C4 CTRP2 6.6341 7.8396 5.5777 1.0734
LS180 CTRP2 6.7755 13.8762 2.7199 12.4609
LS411N CTRP2 6.8622 9.5779 4.904 3.4261
HT-29 CTRP2 6.8728 8.5297 5.4055 1.4453
HCT 116 CTRP2 7.3291 10.4955 4.7767 3.2991
NCI-H716 CTRP2 7.4289 16.4288 1.9561 14.1966
SNU-C2A CTRP2 7.5469 16.2584 2.1291 13.368
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 CTRP2 0.1005 1.3952 -2.361 0.2574
Li-7 CTRP2 3.6098 10.2328 1.6881 23.3169
SNU-398 CTRP2 5.178 7.5465 4.4888 8.4286
SNU-878 CTRP2 5.31 8.0498 4.379 8.5594
Hep-G2 CTRP2 5.4747 7.571 4.7665 6.5827
SNU-761 CTRP2 5.5708 7.3014 4.3187 2.3266
SNU-182 CTRP2 5.8299 7.5524 5.105 4.3831
JHH-5 CTRP2 5.8337 7.8295 4.9707 4.9369
JHH-4 CTRP2 5.8824 13.2179 2.3217 15.7043
HuH-1 CTRP2 5.898 6.9331 5.4728 2.7007
SNU-449 CTRP2 6.004 9.4599 4.3029 7.3979
Hep 3B2.1-7 CTRP2 6.0259 7.506 5.2981 3.1727
SK-HEP-1 CTRP2 6.179 7.098 5.6252 1.5189
JHH-2 CTRP2 6.2592 11.324 3.5814 9.9247
SNU-886 CTRP2 6.319 8.1211 5.2251 2.9489
PLC/PRF/5 CTRP2 6.373 8.8538 4.9033 4.1986
SNU-423 CTRP2 6.5339 9.2888 4.8099 4.3174
SNU-475 CTRP2 6.8879 8.9522 5.219 2.1392
JHH-6 CTRP2 7.8368 8.7214 5.763 0.0311
SNU-387 CTRP2 8.6725 21.4743 0.3951 17.2933
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 143 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1975 CTRP2 4.0892 5.5367 4.0247 13.2457
NCI-H1734 CTRP2 4.1109 7.8401 3.2712 16.0158
NCI-H1693 CTRP2 4.5906 11.8643 1.849 20.2928
HCC44 CTRP2 4.8694 9.7594 3.1354 14.6724
NCI-H211 CTRP2 4.8871 7.435 4.2467 10.1343
LXF 289 CTRP2 5.0176 6.9962 4.5724 8.5053
DMS 53 CTRP2 5.0481 7.4469 4.4046 9.0923
NCI-H2286 CTRP2 5.1213 8.9872 3.7473 11.5946
EPLC-272H CTRP2 5.153 7.4456 4.5105 8.4035
NCI-H1755 CTRP2 5.1598 8.0169 4.2501 9.4431
NCI-H1184 CTRP2 5.1632 6.9812 4.7293 7.5035
HCC15 CTRP2 5.3465 10.8062 3.0595 13.9097
NCI-H1581 CTRP2 5.3974 7.5429 4.7055 7.0153
DMS 454 CTRP2 5.4306 8.4517 4.2975 8.62
NCI-H2087 CTRP2 5.4682 8.3649 4.3748 8.2154
Calu-6 CTRP2 5.5041 6.897 5.1131 5.1
SK-MES-1 CTRP2 5.5457 7.1944 5.0149 5.3971
NCI-H1355 CTRP2 5.5582 8.7662 4.2597 8.4956
COLO 668 CTRP2 5.5789 10.0004 3.6662 10.9228
NCI-H1435 CTRP2 5.5812 7.1366 5.0766 5.06
Lu-99 CTRP2 5.5921 10.1085 3.6241 11.0699
A-549 CTRP2 5.597 11.695 2.8381 14.2696
NCI-H2029 CTRP2 5.6225 18.608 -0.5923 25.5199
NCI-H1373 CTRP2 5.6328 8.9257 4.2478 8.3853
NCI-H661 CTRP2 5.6422 7.7579 4.833 5.9253
NCI-H1915 CTRP2 5.6514 8.6258 4.4131 7.655
NCI-H2228 CTRP2 5.6719 9.4838 4.0052 9.3164
NCI-H1666 CTRP2 5.6788 9.3685 4.0686 9.0367
COR-L88 CTRP2 5.6964 8.8212 4.3563 7.7971
NCI-H1568 CTRP2 5.6968 7.7304 4.8967 5.5399
NCI-H522 CTRP2 5.7117 12.3105 2.63 14.8571
NCI-H1155 CTRP2 5.7238 8.1806 4.6986 6.3078
NCI-H2405 CTRP2 5.726 9.2814 4.1535 8.5837
NCI-H810 CTRP2 5.7684 8.5572 4.5512 6.8302
SK-LU-1 CTRP2 5.7687 9.3435 4.1598 8.4692
NCI-H647 CTRP2 5.7701 11.9783 2.8458 13.8818
HOP-92 CTRP2 5.7722 8.7166 4.4751 7.1409
LUDLU-1 CTRP2 5.7919 7.6563 5.0194 4.822
NCI-H1105 CTRP2 5.8149 15.119 1.3144 19.482
PC-14 CTRP2 5.8205 8.1508 4.7992 5.6828
NCI-H1703 CTRP2 5.8568 17.2652 0.2769 22.6712
DMS 79 CTRP2 5.8735 9.4546 4.1949 8.1093
NCI-H69 CTRP2 5.8809 8.5873 4.6342 6.2507
NCI-H1944 CTRP2 5.8856 7.8083 5.0269 4.5936
NCI-H520 CTRP2 5.8984 8.0796 4.9027 5.0886
VMRC-LCD CTRP2 5.9034 7.9042 4.9945 4.6932
NCI-H2106 CTRP2 5.9057 10.9477 3.4762 11.0422
NCI-H889 CTRP2 5.9148 10.0294 3.9429 9.0822
NCI-H2110 CTRP2 5.9263 9.5415 4.1965 7.997
LCLC-97TM1 CTRP2 5.9401 7.707 5.1247 4.072
SW1271 CTRP2 5.9505 9.2172 4.379 7.183
HCC827 CTRP2 5.9647 8.9315 4.5338 6.5048
EKVX CTRP2 5.9648 10.1521 3.9238 9.0634
NCI-H841 CTRP2 5.9693 7.9564 5.0251 4.4315
RERF-LC-MS CTRP2 5.9694 8.538 4.7346 5.652
NCI-H446 CTRP2 5.9953 8.3098 4.8705 5.0298
NCI-H1694 CTRP2 5.9971 7.9822 5.0358 4.3317
NCI-H358 CTRP2 6.0037 12.7081 2.6785 14.0768
NCI-H1341 CTRP2 6.0051 8.9225 4.5724 6.2633
Calu-3 CTRP2 6.0243 7.6328 5.2334 3.4479
NCI-H1838 CTRP2 6.0285 8.7116 4.6976 5.6919
HCC2108 CTRP2 6.0428 15.9261 1.1023 19.7296
RERF-LC-Ad2 CTRP2 6.1029 16.6214 0.8046 20.5708
NCI-H2171 CTRP2 6.1086 10.7722 3.7338 9.5772
NCI-H2196 CTRP2 6.1308 7.2906 5.4917 2.1615
DV-90 CTRP2 6.1317 15.9887 1.1448 19.4118
RERF-LC-A1 CTRP2 6.1435 8.2643 5.0159 4.1358
IA-LM CTRP2 6.1481 9.1089 4.5977 5.8837
DMS 273 CTRP2 6.1688 10.0152 4.1617 7.6747
NCI-H838 CTRP2 6.1726 8.6248 4.8594 4.7388
COR-L95 CTRP2 6.1806 7.4371 5.4581 2.2138
NCI-H2342 CTRP2 6.1818 10.0481 4.1559 7.6748
LC-1/sq-SF CTRP2 6.186 7.2035 5.5782 1.7025
NCI-H1092 CTRP2 6.189 8.1062 5.1314 3.5675
NCI-H650 CTRP2 6.1974 10.9962 3.6948 9.571
Sq-1 CTRP2 6.2001 9.0194 4.6846 5.4221
EBC-1 CTRP2 6.2238 8.2603 5.0822 3.7113
NCI-H2172 CTRP2 6.2245 7.7583 5.3325 2.6622
NCI-H292 CTRP2 6.2256 9.4682 4.4811 6.2296
NCI-H1395 CTRP2 6.2298 9.8062 4.3157 6.9153
NCI-H441 CTRP2 6.2357 10.7 3.8741 8.7524
NCI-H1339 CTRP2 6.2439 7.9051 5.2746 2.8703
DMS 114 CTRP2 6.2502 7.9014 5.2813 2.8317
NCI-H322 CTRP2 6.255 8.1386 5.1672 3.3001
CAL-12T CTRP2 6.2652 8.3465 5.0718 3.6812
LK2 CTRP2 6.2689 9.6244 4.4378 6.3315
LOU-NH91 CTRP2 6.2851 10.3059 4.1108 7.6719
NCI-H2009 CTRP2 6.3002 9.8599 4.3454 6.6621
NCI-H2023 CTRP2 6.3211 8.1735 5.2008 3.0464
NCI-H2122 CTRP2 6.3292 7.7571 5.4123 2.1554
NCI-H2291 CTRP2 6.3332 8.6946 4.9516 4.0655
NCI-H1573 CTRP2 6.3369 10.1161 4.2469 7.0081
Lu-65 CTRP2 6.3484 10.158 4.2351 7.0365
COR-L47 CTRP2 6.3656 39.0787 -10.2058 37.4012
NCI-H23 CTRP2 6.3717 8.6094 5.0235 3.6996
NCI-H2126 CTRP2 6.3763 8.7516 4.9565 3.971
SHP-77 CTRP2 6.3802 7.9873 5.3366 2.3861
LCLC-103H CTRP2 6.4077 7.9152 5.3918 2.1162
NCI-H526 CTRP2 6.4088 14.5933 2.0697 15.6201
HCC1171 CTRP2 6.4184 10.2098 4.2646 6.7882
NCI-H727 CTRP2 6.4242 9.2609 4.7406 4.7895
COR-L51 CTRP2 6.426 18.8315 -0.034 22.4374
SW1573 CTRP2 6.4423 13.2808 2.7522 12.9429
NCI-H1299 CTRP2 6.4573 8.5257 5.1288 3.1213
MOR/CPR CTRP2 6.4676 8.9992 4.9031 4.0397
NCI-H1563 CTRP2 6.4833 8.5272 5.1471 3.0044
ChaGo-K-1 CTRP2 6.4839 13.4779 2.6872 13.121
T3M-10 CTRP2 6.5015 11.43 3.7224 8.8981
NCI-H226 CTRP2 6.5152 8.0557 5.3989 1.928
NCI-H1650 CTRP2 6.5399 11.8194 3.5587 9.5051
NCI-H2170 CTRP2 6.5457 10.0488 4.4431 5.8227
HOP-62 CTRP2 6.5829 9.9456 4.5224 5.4301
HCC78 CTRP2 6.5901 8.6315 5.1726 2.7358
NCI-H2085 CTRP2 6.6262 18.316 0.3865 20.8404
KNS-62 CTRP2 6.6343 8.3087 5.3581 1.925
NCI-H2444 CTRP2 6.6492 8.1903 5.4239 1.6457
BEN CTRP2 6.6845 7.6983 5.6703 0.6852
HCC95 CTRP2 6.7016 9.7041 4.7291 4.3817
HCC1588 CTRP2 6.7169 10.7356 4.2329 6.4083
SBC-5 CTRP2 6.7313 8.7874 5.1945 2.444
HCC1195 CTRP2 6.7663 9.7306 4.7628 4.1432
RERF-LC-Ad1 CTRP2 6.7853 7.8401 5.6629 0.6193
NCI-H1651 CTRP2 6.788 9.2448 5.0135 3.0909
NCI-H1793 CTRP2 6.7997 10.805 4.2605 6.1583
HCC2935 CTRP2 6.8728 9.8938 4.7587 3.9992
HCC366 CTRP2 7.0699 13.2224 3.2701 9.7649
NCI-H1869 CTRP2 7.1256 13.8326 3.0105 10.7075
Calu-1 CTRP2 7.1639 9.045 5.3424 1.3651
NCI-H2030 CTRP2 7.2204 13.4635 3.2635 9.5428
NCI-H1792 CTRP2 7.2269 13.6559 3.1735 9.8912
HCC1438 CTRP2 7.2599 10.8666 4.5556 4.2636
NCI-H2081 CTRP2 7.2774 9.454 5.2245 1.6704
HCC2279 CTRP2 7.445 16.0349 2.1629 13.4149
NCI-H2141 CTRP2 7.49 17.6235 1.411 16.0029
COLO 699 CTRP2 7.5249 16.1847 2.149 13.332
NCI-H196 CTRP2 7.5623 13.4261 3.5293 7.9408
HCC4006 CTRP2 7.6245 9.2717 5.4805 0.5729
HARA [Human squamous cell lung carcinoma] CTRP2 8.1743 18.6632 1.4101 14.8689
NCI-H1623 CTRP2 8.1879 17.4887 1.9954 12.8155
NCI-H460 CTRP2 8.3381 13.8296 3.8569 5.5793
HCC1833 CTRP2 8.852 20.4811 1.011 15.1181
COR-L105 CTRP2 10.5735 26.597 -0.7459 17.671
Hs 888.Lu CTRP2 5.9238 8.7597 4.5849 6.3713
⏷ Show the Full List of 143 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 5.678 9.2258 4.1389 8.7449
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
P-STS CTRP2 5.7965 6.7584 5.4644 2.9626
H-STS CTRP2 6.0344 6.6742 5.7211 1.3784
SYO-1 CTRP2 6.2988 8.1392 5.2007 3.0845
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 5.9343 9.9968 3.9757 8.9065
A2780 CTRP2 4.9632 7.1855 4.4345 9.192
COV434 CTRP2 5.5686 8.6767 4.3133 8.2495
Caov-3 CTRP2 5.6704 9.7774 3.8577 9.9347
IGROV-1 CTRP2 5.8294 7.5999 5.0809 4.485
Kuramochi CTRP2 5.9136 8.9667 4.4729 6.862
OAW42 CTRP2 6.0026 6.7524 5.655 1.7195
FU-OV-1 CTRP2 6.0321 8.5889 4.7619 5.4146
RMG-I CTRP2 6.0761 10.7106 3.7377 9.6238
OVTOKO CTRP2 6.0922 8.6532 4.7796 5.2247
OVCAR-8 CTRP2 6.1124 8.4612 4.8922 4.7136
OVK18 CTRP2 6.1334 9.2164 4.532 6.1873
SK-OV-3 CTRP2 6.1421 8.4358 4.9291 4.5027
HEY A8 CTRP2 6.1736 9.1869 4.5794 5.9128
SNU-119 CTRP2 6.1832 7.87 5.2445 3.1038
TYK-nu CTRP2 6.1873 8.5306 4.9183 4.4647
OV-90 CTRP2 6.1979 9.2272 4.5791 5.8691
JHOM-1 CTRP2 6.2604 8.9589 4.763 4.9833
OC 314 CTRP2 6.2655 8.0302 5.2292 3.0227
MCAS CTRP2 6.3082 8.2294 5.1632 3.2248
ONCO-DG-1 CTRP2 6.3206 9.2586 4.6613 5.302
JHOS-2 CTRP2 6.3378 9.5204 4.5445 5.7604
OVCAR-5 CTRP2 6.3378 9.0117 4.7976 4.7012
COV644 CTRP2 6.3673 8.2835 5.1812 3.0508
OV7 CTRP2 6.4024 10.0215 4.3457 6.4775
EFO-21 CTRP2 6.4113 8.7715 4.9732 3.8423
EFO-27 CTRP2 6.4377 10.655 4.0581 7.6159
DOV13 CTRP2 6.4565 8.6254 5.0792 3.3279
ES2 CTRP2 6.5103 8.7526 5.0562 3.3364
TOV-112D CTRP2 6.5413 8.7473 5.0814 3.1836
OVSAHO CTRP2 6.5944 10.1617 4.4242 5.8187
COV362 CTRP2 6.6398 10.6419 4.221 6.5868
SNU-840 CTRP2 6.6598 11.3332 3.8937 7.9105
OAW28 CTRP2 6.6692 12.8514 3.1465 10.955
JHOC-5 CTRP2 6.7056 7.9535 5.5684 1.0279
OVCAR-4 CTRP2 6.9031 10.3273 4.5695 4.7251
SNU-8 CTRP2 6.9292 9.8149 4.8358 3.6047
OVISE CTRP2 7.1211 11.1821 4.3082 5.4612
OV56 CTRP2 7.7478 9.3232 5.5148 0.4246
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 6.0853 7.3315 5.4346 2.4853
Yamato-SS CTRP2 6.2574 8.1677 5.1546 3.3485
A-204 CTRP2 5.4005 8.3672 4.3108 8.6327
Rh41 CTRP2 5.4505 8.1444 4.466 7.8772
G-401 CTRP2 5.4742 11.3085 2.9233 14.1862
TE 617.T CTRP2 5.6449 8.7291 4.3562 7.9065
TE 441.T CTRP2 5.687 10.3321 3.5959 10.9896
G-402 CTRP2 5.7573 9.2165 4.2131 8.2692
Rh18 CTRP2 5.8949 8.0962 4.8914 5.1429
TTC-709 CTRP2 5.9081 8.3859 4.7582 5.6751
Hs 729.T CTRP2 6.031 9.0784 4.5163 6.4489
KYM-1 CTRP2 6.0349 8.4626 4.8274 5.134
SK-LMS-1 CTRP2 6.0359 8.9365 4.5912 6.1245
HT-1080 CTRP2 6.0605 7.2048 5.4776 2.3514
MES-SA CTRP2 6.0606 6.9119 5.6241 1.7359
BT-12 CTRP2 6.1028 7.6855 5.272 3.1356
SW982 CTRP2 6.1682 7.5469 5.3937 2.5054
BT-16 CTRP2 6.1858 7.3296 5.5155 1.9648
GCT CTRP2 6.251 7.9987 5.2336 3.0297
Tm87-16 CTRP2 6.3897 8.3403 5.17 3.0603
RKN CTRP2 6.4066 8.2425 5.2307 2.7815
SK-UT-1 CTRP2 6.572 9.725 4.6232 5.0295
RD CTRP2 6.7227 11.9535 3.6344 8.8725
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 CTRP2 5.2371 9.0914 3.8051 11.0927
MSTO-211H CTRP2 5.3871 6.9538 4.9697 5.97
NCI-H2052 CTRP2 5.3984 8.2591 4.3615 8.4279
MPP 89 CTRP2 5.9279 7.2174 5.3582 3.1174
JL-1 CTRP2 6.0967 7.4625 5.3784 2.6999
IST-Mes1 CTRP2 6.3377 7.9379 5.3296 2.4836
ACC-MESO-1 CTRP2 6.3764 8.8125 4.9263 4.0965
NCI-H28 CTRP2 6.4897 8.8155 5.0102 3.5595
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 5.5689 10.143 3.5865 11.2743
PaCa-3 CTRP2 6.1531 6.9464 5.6805 1.3323
DU145 CTRP2 6.3829 10.2818 4.2008 7.1181
VCaP CTRP2 6.4438 8.4441 5.159 3.0181
22Rv1 CTRP2 6.5298 13.1327 2.8962 12.2102
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 5.5858 8.4938 4.4193 7.7706
A-253 CTRP2 7.5029 14.9255 2.753 11.0907
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ECC10 CTRP2 4.0553 7.1418 3.4996 15.2838
GSS CTRP2 5.2503 7.1346 4.7499 7.197
SNU-1 CTRP2 5.2783 7.999 4.3731 8.6582
HGC-27 CTRP2 5.3338 7.3824 4.7192 7.1129
SNU-16 CTRP2 5.484 7.3202 4.8953 6.0328
NUGC-4 CTRP2 5.5583 8.9323 4.1778 8.8368
Fu97 CTRP2 5.8253 7.6337 5.0605 4.579
KATO III CTRP2 5.8283 7.9448 4.9086 5.2081
NCI-N87 CTRP2 5.8339 9.891 3.943 9.244
NUGC-3 CTRP2 5.883 9.0157 4.4222 7.1366
SNU-216 CTRP2 5.9709 9.5559 4.2271 7.7808
23132/87 CTRP2 6.0277 7.4831 5.311 3.115
MKN1 CTRP2 6.071 8.4069 4.8852 4.8212
SNU-5 CTRP2 6.0904 7.8426 5.1833 3.5317
IM95 CTRP2 6.096 7.6681 5.2751 3.1353
MKN74 CTRP2 6.1418 9.1233 4.5853 5.9475
Hs 746.T CTRP2 6.1439 8.839 4.7292 5.3392
SNU-719 CTRP2 6.2991 8.4999 5.0219 3.8308
KE-39 CTRP2 6.311 9.5407 4.5132 5.9395
SNU-620 CTRP2 6.3412 7.3713 5.609 1.3302
SNU-668 CTRP2 6.4562 9.2282 4.7813 4.5653
SH-10-TC CTRP2 6.4893 14.1751 2.3436 14.4389
OCUM-1 CTRP2 6.5525 9.3958 4.771 9.4987
LMSU CTRP2 6.619 16.3494 1.3626 17.7369
ECC12 CTRP2 6.623 8.67 5.1769 2.6695
MKN45 CTRP2 6.6427 8.2666 5.3836 1.8128
SNU-601 CTRP2 6.655 8.5177 5.2722 2.2394
GSU CTRP2 6.774 7.5753 5.7677 0.3082
AGS CTRP2 7.0166 10.1555 4.7318 3.899
MKN7 CTRP2 8.5505 20.0807 0.9895 15.652
HuG1-N CTRP2 8.7079 26.1736 -1.8958 23.1319
SNG-M CTRP2 6.1813 7.9978 5.1793 3.3804
SNU-685 CTRP2 6.3118 9.7416 4.4136 6.3551
SNU-1077 CTRP2 6.8779 10.8037 4.3186 5.7934
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8305C CTRP2 5.3876 7.0767 4.9142 6.1915
SW579 CTRP2 5.8136 7.4572 5.1375 4.2822
TT CTRP2 5.8202 9.0767 4.3376 7.6185
FTC-238 CTRP2 5.9076 7.5744 5.1626 3.9792
ML-1 [Human leukemia] CTRP2 5.9753 8.2819 4.8676 5.0814
8505C CTRP2 6.079 7.8446 5.173 3.5967
TT2609-C02 CTRP2 6.1342 10.9879 3.6471 9.8888
CAL-62 CTRP2 6.1641 9.1031 4.6136 5.787
BHT-101 CTRP2 6.1652 8.1091 5.1109 3.697
B-CPAP CTRP2 6.3128 9.4047 4.5824 5.6463
FTC-133 CTRP2 6.3604 9.6003 4.5224 5.8128
CGTH-W-1 CTRP2 6.5788 8.9947 4.9874 3.5116
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 5.4454 9.8298 3.6319 11.3494
SNU-1214 CTRP2 5.4651 8.567 4.2729 8.6449
PE/CA-PJ15 CTRP2 5.6519 13.5811 1.9442 17.5926
SCC-25 CTRP2 5.6722 7.4515 5.0109 5.1204
CAL-27 CTRP2 5.8494 7.146 5.3237 3.4281
PE/CA-PJ34 (clone C12) CTRP2 5.9402 8.8187 4.5695 6.4035
BHY CTRP2 5.986 8.6358 4.6997 5.766
FaDu CTRP2 5.9883 10.1464 3.9465 8.9224
BICR 31 CTRP2 6.0159 16.2594 0.9132 20.3988
YD-8 CTRP2 6.0219 9.178 4.4588 6.7081
BICR 22 CTRP2 6.0645 7.1134 5.5265 2.1383
BICR 6 CTRP2 6.1219 8.6871 4.7871 5.1371
CAL-33 CTRP2 6.152 7.5411 5.3837 2.5761
PE/CA-PJ49 CTRP2 6.1764 7.897 5.2257 3.1946
HSC-3 CTRP2 6.1895 7.5164 5.4255 2.3344
SNU-899 CTRP2 6.2681 8.6591 4.9185 4.3179
SNU-1066 CTRP2 6.281 8.8879 4.8147 4.73
SCC-9 CTRP2 6.2868 11.9834 3.2744 11.1358
Detroit 562 CTRP2 6.3001 8.5001 5.0226 3.8262
HSC-4 CTRP2 6.5183 9.233 4.8258 4.277
SNU-1041 CTRP2 6.5439 12.4552 3.2452 10.7806
BICR 18 CTRP2 6.5927 9.5642 4.718 4.6022
HSC-2 CTRP2 6.7599 10.3344 4.4626 5.3883
SNU-1076 CTRP2 6.7878 12.3014 3.5117 9.263
BICR 16 CTRP2 7.021 8.8521 5.3468 1.4982
SCC-4 CTRP2 7.779 16.6693 2.0991 13.0944
BICR 56 CTRP2 7.9018 13.3109 3.8182 6.304
SNU-46 CTRP2 9.3629 22.2278 0.5238 15.8609
PE/CA-PJ41 (clone D2) CTRP2 9.6467 20.2833 1.657 11.8554
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
253J CTRP2 4.18 6.3606 3.9154 13.3609
JMSU-1 CTRP2 5.2077 7.1779 4.6873 7.5555
BC-3C CTRP2 5.7373 10.7631 3.4245 11.5952
HT-1197 CTRP2 5.7669 9.297 4.1815 17.657
RT-4 CTRP2 5.8261 8.3472 4.7064 6.0599
5637 CTRP2 5.8942 14.3716 1.755 17.7813
647V CTRP2 5.9711 7.6808 5.1643 3.8431
VM-CUB-1 CTRP2 6.0057 8.6424 4.713 5.6713
253J-BV CTRP2 6.1385 8.695 4.7967 5.0656
SW1710 CTRP2 6.1848 8.6744 4.8445 4.7789
UM-UC-3 CTRP2 6.1889 9.1383 4.6161 5.7305
UM-UC-1 CTRP2 6.2542 10.1177 4.1798 7.4397
KU-19-19 CTRP2 6.2558 8.1978 5.1384 3.4194
T24 CTRP2 6.2596 8.1566 5.1618 3.3147
HT-1376 CTRP2 6.3654 10.2097 4.2228 7.0573
U-BLC1 CTRP2 6.3658 9.4979 4.5776 5.5722
BFTC-905 CTRP2 6.3743 7.9601 5.3456 2.3585
TCCSUP CTRP2 6.5378 8.8266 5.04 3.3594
RT-112 CTRP2 6.5995 8.4972 5.2441 2.4315
CAL-29 CTRP2 6.6608 10.1944 4.458 5.5681
J82 CTRP2 6.7007 9.9693 4.5984 4.9222
SCaBER CTRP2 6.7119 10.7663 4.214 6.4952
639V CTRP2 6.7355 8.38 5.39 1.6677
KMBC-2 CTRP2 7.1429 10.6559 4.5775 4.34
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 6.0377 6.7207 5.7006 1.458

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017888)
2 O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas. Cell Death Dis. 2013 Oct 24;4:e876.
3 O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts. Br J Cancer. 2005 Nov 14;93(10):1152-6. doi: 10.1038/sj.bjc.6602833.