Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT8SQBG)

• DTP Name: Glucose transporter type 7 (SLC2A7)
• Gene Name: SLC2A7
• UniProt ID: Q6PXP3 (GTR7_HUMAN)
• VARIDT ID: DTD0265
• Synonyms: GLUT-7; GLUT7; SLC2A7; Solute carrier family 2, facilitated glucose transporter member 7
• DTP Family:
  Major Facilitator Superfamily (MFS)
  Sugar Porter (SP) Family
• Tissue Specificity: Expressed in small intestine and colon. Weaklyexpressed in testis and prostate.
• Sequence:
  MENKEAGTPPPIPSREGRLQPTLLLATLSAAFGSAFQYGYNLSVVNTPHKVFKSFYNETY
  FERHATFMDGKLMLLLWSCTVSMFPLGGLLGSLLVGLLVDSCGRKGTLLINNIFAIIPAI
  LMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGV
  FLAQIFSLQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQAL
  RRLRGHTDMEAELEDMRAEARAERAEGHLSVLHLCALRSLRWQLLSIIVLMAGQQLSGIN
  AINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAGYGICGS
  ACLVLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMV
  DGAVHWLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPETKGKTFVEINRI
  FAKRNRVKLPEEKEETIDAGPPTASPAKETSF
• Function: This high-affinity transporter is for glucose and fructose.
• Endogenous Substrate(s): Glucose
• TCDB ID: 2.A.1.1.37
• Gene ID: 155184
• Reactome Pathway: Cellular hexose transport (R-HSA-189200)

Molecular Interaction Atlas (MIA) of This DTP

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[1]
Fructose	DM43AN2	Vomiting	MD90	Approved	[1]

Drug Affinity of This DTP Assessed by Cell Line

Approved Drug(s)

Drug Name	Highest Status	Cell Line	Affinity	REF
2-deoxyglucose	Approved	Xenopus oocytes-GLUT7	Km = 300.0 microM	[1]

References

• [1] Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128.