Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTGMT94)

DTP Name	Annexin A2 (ANXA2)
Gene Name	ANXA2
UniProt ID	P07355 (ANXA2_HUMAN)
VARIDT ID	DTD0542
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Synonyms	Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36
DTP Family	Annexin (Annexin) Family ;
Sequence	MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNIL TNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKG LGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRA EDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDM LESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDM LKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
Function	This transporter binds two calcium ions with high affinity. Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids.
Endogenous Substrate(s)	Annexin a2; Ions
TCDB ID	1.A.31.1.4
Gene ID	302
KEGG Pathway	Salmonella infection (hsa05132 )
Reactome Pathway	Neutrophil degranulation (R-HSA-6798695 ) Dissolution of Fibrin Clot (R-HSA-75205 ) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (R-HSA-8950505 ) Smooth Muscle Contraction (R-HSA-445355 )

The Drug Therapeutic Target (DTT) Role of This DTP