Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT2QM9D)

• DTT Name: Adenylate cyclase (ADCY) DTT Info
• Gene Name: ADCY

Molecule-Related Drug & Molecule List

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ad5-AC6	DMQNFZE	Cardiac failure	BD10-BD13	Terminated	[1]

9 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,5-didesoxy-3-ATP	DM5CWM0	Discovery agent	N.A.	Investigative	[2]
2-hydroxy-17beta-estradiol	DMM9Z0B	Discovery agent	N.A.	Investigative	[2]
Adenosine-5'-Rp-Alpha-Thio-Triphosphate	DMKY7T8	Discovery agent	N.A.	Investigative	[3]
DEOXYADENOSINE	DMS6X1I	N. A.	N. A.	Investigative	[4]
N6-CYCLOPENTYLADENOSINE	DMD6AJO	Discovery agent	N.A.	Investigative	[5]
NSC-270718	DMUNIWE	Discovery agent	N.A.	Investigative	[2]
NSC-88915	DM9WIHJ	Solid tumour/cancer	2A00-2F9Z	Investigative	[2]
[3H]alphabeta-meATP	DMWV5C3	Discovery agent	N.A.	Investigative	[6]
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[6]

References

• [1] Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758.
• [2] Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64.
• [3] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [4] Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. J Med Chem. 2004 Feb 26;47(5):1207-13.
• [5] Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. J Med Chem. 1991 Dec;34(12):3388-90.
• [6] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.