Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT5YPJF)

DTT Name CD80-PD-L1 interaction (CD80/PD-L1 PPI)
Synonyms T-lymphocyte activation antigen CD80/Programmed cell death 1 ligand 1 PPI
Gene Name CD80-CD274
DTT Type
Patented-recorded target
 [1]
UniProt ID
CD80_HUMAN-PD1L1_HUMAN
TTD ID
T18551
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEETMGHTRRQGTS
PSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEK
KMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREH
LAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVS
QDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNLLPSWAIT
LISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
Function Augments activated alloreactive CD4+ T cell proliferation and apoptosis and ameliorates acute graft versus host disease

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
13 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Biaryl compound 1 DMHEAJQ Hepatitis DB97.Z Patented [1]
Biaryl compound 2 DMS8VYE Hepatitis DB97.Z Patented [1]
Macrocycle derivative 1 DMN7I9C Hepatitis DB97.Z Patented [1]
Macrocycle derivative 2 DM5OEQZ Hepatitis DB97.Z Patented [1]
Macrocycle derivative 3 DMYGFTI Hepatitis DB97.Z Patented [1]
Macrocycle derivative 4 DMOQBN4 Hepatitis DB97.Z Patented [1]
Macrocycle derivative 5 DMK3UJY Hepatitis DB97.Z Patented [1]
Macrocycle derivative 6 DMQ84KW Hepatitis DB97.Z Patented [1]
Macrocycle derivative 7 DMP2JF0 Hepatitis DB97.Z Patented [1]
Macrocycle derivative 8 DMOMTBE Hepatitis DB97.Z Patented [1]
Macrocycle derivative 9 DMARU0E Hepatitis DB97.Z Patented [1]
PMID30107136-Compound-Example11 DMD65GU Hepatitis DB97.Z Patented [1]
PMID30107136-Compound-Example12 DMN2K10 Hepatitis DB97.Z Patented [1]
------------------------------------------------------------------------------------
⏷ Show the Full List of 13 Patented Agent(s)

References

1 A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678.