Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8R0BZ)

• DTT Name: Elongation factor 1A (EF1A)
• Synonyms: eEF1A; Eukaryotic elongation factor 1 A; Elongation factor 1-alpha; Elongation factor; EF-1-alpha
• Gene Name: EEF1A1
• DTT Type: Literature-reported target; [1]
• UniProt ID: EF1A1_HUMAN ; EF1A2_HUMAN
• TTD ID: T72269
• Sequence:
  MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL
  DKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV
  GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKK
  IGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTR
  PTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALS
  EALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPV
  LDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPP
  LGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
• Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
• KEGG Pathway:
  Nucleocytoplasmic transport (hsa03013)
  Legionellosis (hsa05134)
  Leishmaniasis (hsa05140)
• Reactome Pathway:
  Peptide chain elongation (R-HSA-156902)
  HSF1 activation (R-HSA-3371511)
  Neutrophil degranulation (R-HSA-6798695)
  Protein methylation (R-HSA-8876725)
  Chaperone Mediated Autophagy (R-HSA-9613829)
  Eukaryotic Translation Elongation (R-HSA-156842)

Molecular Interaction Atlas (MIA) of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Narciclasine	DMI7A6R	Melanoma	2C30	Investigative	[1]

References

• [1] Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas. FASEB J. 2010 Nov;24(11):4575-84.