Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTCYAXN)

DTT Name Chloride channel unspecific (ClC)
Gene Name ClC
DTT Type
Successful target
 [1]
UniProt ID
NOUNIPROTAC
TTD ID
T57585

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
4 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
131I-TM-601 DMTIED1 Glioma 2A00.0 Phase 2 [2]
Lancovutide DM7MBV6 Chronic obstructive pulmonary disease CA22 Phase 2 [3]
TM-601 DMKV5UM Solid tumour/cancer 2A00-2F9Z Phase 2 [4]
BLZ-100 DMFKA4G Glioma 2A00.0 Phase 1/2 [5]
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3 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
GR-213487 DMCXLIK Cystic fibrosis CA25 Discontinued in Phase 2 [6]
TgAAV-CFTR DMQSNV8 Cystic fibrosis CA25 Discontinued in Phase 2 [7]
Endovion DMJU39N Solid tumour/cancer 2A00-2F9Z Terminated [8]
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References

1 Haemonchus contortus: selection at a glutamate-gated chloride channel gene in ivermectin- and moxidectin-selected strains. Exp Parasitol. 1998 Sep;90(1):42-8.
2 Imaging glioma extent with 131I-TM-601. J Nucl Med. 2005 Apr;46(4):580-6.
3 Airway-rehydrating agents for the treatment of cystic fibrosis: past, present, and future. Ann Pharmacother. 2011 Jan;45(1):49-59.
4 NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels. Biochemistry. 1995 Jan 10;34(1):13-21.
5 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
6 EP patent application no. 1336602, Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases.
7 Novel molecular approaches to cystic fibrosis gene therapy. Biochem J. 2005 April 1; 387(Pt 1): 1-15.
8 Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas. J Membr Biol. 2003 Nov 15;196(2):83-94.