Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTCYAXN)

• DTT Name: Chloride channel unspecific (ClC) DTT Info
• Gene Name: ClC

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
131I-TM-601	DMTIED1	Glioma	2A00.0	Phase 2	[1]
Lancovutide	DM7MBV6	Chronic obstructive pulmonary disease	CA22	Phase 2	[2]
TM-601	DMKV5UM	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
BLZ-100	DMFKA4G	Glioma	2A00.0	Phase 1/2	[4]

3 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GR-213487	DMCXLIK	Cystic fibrosis	CA25	Discontinued in Phase 2	[5]
TgAAV-CFTR	DMQSNV8	Cystic fibrosis	CA25	Discontinued in Phase 2	[6]
Endovion	DMJU39N	Solid tumour/cancer	2A00-2F9Z	Terminated	[7]

References

• [1] Imaging glioma extent with 131I-TM-601. J Nucl Med. 2005 Apr;46(4):580-6.
• [2] Airway-rehydrating agents for the treatment of cystic fibrosis: past, present, and future. Ann Pharmacother. 2011 Jan;45(1):49-59.
• [3] NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels. Biochemistry. 1995 Jan 10;34(1):13-21.
• [4] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
• [5] EP patent application no. 1336602, Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases.
• [6] Novel molecular approaches to cystic fibrosis gene therapy. Biochem J. 2005 April 1; 387(Pt 1): 1-15.
• [7] Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas. J Membr Biol. 2003 Nov 15;196(2):83-94.