Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTG25NJ)

DTT Name	Vesicle-associated membrane protein (VAMP)
Synonyms	VAMP; Synaptobrevin; SYB
Gene Name	VAMP1
DTT Type	Successful target	[1]
UniProt ID	VAMP1_HUMAN ; VAMP2_HUMAN
TTD ID	T30028
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVLERDQ KLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVIYFFT
Function	Involved in the targeting and/or fusion of transport vesicles to their target membrane.
KEGG Pathway	SNARE interactions in vesicular transport (hsa04130 )
Reactome Pathway	Toxicity of botulinum toxin type F (botF) (R-HSA-5250981 ) Toxicity of botulinum toxin type G (botG) (R-HSA-5250989 ) Toxicity of botulinum toxin type D (botD) (R-HSA-5250955 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Botulinum Toxin Type B	DM58QS1	Parkinson disease	8A00.0	Approved	[1]
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References

1	Long-lasting benefits of botulinum toxin type B in Parkinson's disease-related drooling. J Neurol. 2009 Apr;256(4):563-7.