Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTI0TCK)

DTT Name Mycobacterium CDP-diacylglycerol-inositol phosphatidyltransferase (MycB pssA)
Synonyms pssA; PtdIns synthase; Phosphatidylinositol synthase; PI synthase
Gene Name MycB pssA
DTT Type
Clinical trial target
 [1]
BioChemical Class
Kinase
UniProt ID
PSS_MYCTU
TTD ID
T55936
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.7.8.8
Sequence
MIGKPRGRRGVNLQILPSAMTVLSICAGLTAIKFALEHQPKAAMALIAAAAILDGLDGRV
ARILDAQSRMGAEIDSLADAVNFGVTPALVLYVSMLSKWPVGWVVVLLYAVCVVLRLARY
NALQDDGTQPAYAHEFFVGMPAPAGAVSMIGLLALKMQFGEGWWTSGWFLSFWVTGTSIL
LVSGIPMKKMHAVSVPPNYAAALLAVLAICAAAAVLAPYLLIWVIIIAYMCHIPFAVRSQ
RWLAQHPEVWDDKPKQRRAVRRASRRAHPYRPSMARLGLRKPGRRL
Function
Catalyzes the biosynthesis of phosphatidylinositol (ptdins) as well as ptdins:inositol exchange reaction. May thus act to reduce an excessive cellular ptdins content. The exchange activity is due to the reverse reaction of ptdins synthase.
KEGG Pathway
Glycine, serine and threonine metabolism (mtu00260 )
Glycerophospholipid metabolism (mtu00564 )
Metabolic pathways (mtu01100 )
Biosynthesis of secondary metabolites (mtu01110 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Myo-inositol DMQKSGI Alzheimer disease 8A20 Phase 2 [1]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zn2+ DMEC1I9 Discovery agent N.A. Investigative [1]
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References

1 Phosphatidylinositol synthesis in mycobacteria. Biochim Biophys Acta. 1999 Jan 4;1436(3):437-50.