Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQ79W8)

DTT Name Apoptosis regulator Bcl-W (BCL-W)
Synonyms KIAA0271; Bcl2-L-2; Bcl-2-like protein 2; BCLW
Gene Name BCL2L2
DTT Type
Clinical trial target
 [1]
BioChemical Class
B-cell lymphoma Bcl-2
UniProt ID
B2CL2_HUMAN
TTD ID
T03755
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT
FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG
QVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL
GALVTVGAFFASK
Function Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Promotes cell survival.
KEGG Pathway
MicroRNAs in cancer (hsa05206 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ABT-263 DMNE56X Myelofibrosis 2A20.2 Phase 3 [1]
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1 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID27744724-Compound-18 DM73S2C N. A. N. A. Patented [2]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Lung cancer 2C82 Lung tissue 1.83E-48 -0.69 -1.67
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References

1 Clinical pipeline report, company report or official report of Roche (2009).
2 Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178.