Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTSMPXQ)

DTT Name	S-adenosylmethionine synthase type-2 (MAT2A)
Synonyms	Methionine adenosyltransferase II; Methionine adenosyltransferase 2; MAT-II; MAT 2; AdoMet synthase 2
Gene Name	MAT2A
DTT Type	Clinical trial target	[1]
BioChemical Class	AdoMet synthase family
UniProt ID	METK2_HUMAN
TTD ID	T97008
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.5.1.6
Sequence	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVA KTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS KTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDT IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
Function	Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
KEGG Pathway	Cysteine and methionine metabolism (hsa00270 ) Metabolic pathways (hsa01100 ) Biosynthesis of amino acids (hsa01230 )
Reactome Pathway	Methylation (R-HSA-156581 )
BioCyc Pathway	MetaCyc:HS09847-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AG-270	DMYTJG7	Lymphoma	2A80-2A86	Phase 1	[1]
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

S-adenosylmethionine synthase 2 (MAT2A) DME Info

Gene Name

MAT2A

1 Investigative Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-methionine	DME8G1U	Discovery agent	N.A.	Investigative	[2]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18.