Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTUBNVO)

• DTT Name: DNA synthesis (DNA synth)
• Gene Name: DNA synth
• DTT Type: Successful target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T30418

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nelarabine	DMB6VEG	leukaemia	2A60-2B33	Approved	[2]

4 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
acelarin	DMY96O3	Biliary tract cancer	2C17	Phase 3	[1]
Glufosfamide	DMEFCTP	Pancreatic cancer	2C10	Phase 3	[1]
FF-10502-01	DMX5290	Lymphoma	2A80-2A86	Phase 1	[1]
TAR-200	DMSQZEP	Bladder cancer	2C94	Phase 1	[1]

2 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CLOTURIN	DMKFMYR	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[3]
EPD-clofarabine	DM149HL	Solid tumour/cancer	2A00-2F9Z	Terminated	[4]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Nelarabine. Drugs. 2008;68(4):439-47.
• [3] Inhibition of biosynthetic processes in P388 and Ehrlich ascites cells by cloturin. Drugs Exp Clin Res. 1988;14(9):575-80.
• [4] 2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.