Details of the Drug

General Information of Drug (ID: DMB6VEG)

Drug Name
Nelarabine
Synonyms
Arranon; ArranonG; Atriance; Nelzarabine; Nelarabine [USAN]; Nelzarabine [USAN]; GW 506U78; GW506U78; U78; Arranon (GlaxoSmithKline); Arranon (TN); Arranon, Nelarabine; Atriance (TN); GW-506U; GW-506U78; Nelarabine (INN); Nelzarabine (USAN); O-Methoxydeoxyguanosine; O-Methylguanosine; Nelarabine (JAN/USAN); (2R,3R,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 2-(2-Amino-6-methoxy-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol; 2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 2-Amino-6-methoxypurine arabinoside; 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine; 6'-O-Methylguanosine; 9-beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine; 9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
Indication
Disease Entry ICD 11 Status REF
leukaemia 2A60-2B33 Approved [1]
T-cell acute lymphoblastic leukaemia 2A90.5 Approved [2]
T-lymphoblastic lymphoma N.A. Approved [2]
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
ATC Code
L01BB07: Nelarabine
L01BB: Purine analogues
L01B: ANTIMETABOLITES
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 297.27
Logarithm of the Partition Coefficient (xlogp) -0.7
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 9
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [3]
Clearance
The drug present in the plasma can be removed from the body at the rate of 81 mL/min/kg [4]
Elimination
6.6% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 3 hours [4]
Metabolism
The drug is metabolized via the adenosine deaminase to form ara-G, which undergoes hydrolysis to form guanine []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 4.234 micromolar/kg/day [5]
Unbound Fraction
The unbound fraction of drug in plasma is 0.8% [4]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 4.9 L/kg [4]
Water Solubility
The ability of drug to dissolve in water is measured as 1 mg/mL [3]
Chemical Identifiers
Formula
C11H15N5O5
IUPAC Name
(2R,3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Canonical SMILES
COC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N
InChI
InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1
InChIKey
IXOXBSCIXZEQEQ-UHTZMRCNSA-N
Cross-matching ID
PubChem CID
3011155
ChEBI ID
CHEBI:63612
CAS Number
121032-29-9
UNII
60158CV180
DrugBank ID
DB01280
TTD ID
D0B8UJ
INTEDE ID
DR1136
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA synthesis (DNA synth) TTUBNVO NOUNIPROTAC Binder [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Adenosine aminohydrolase (ADA)
Main DME 		DEDQHBV ADA_HUMAN Substrate [7]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 6.7705 8.5275 3.7492 0.367
EW-3 GDSC2 3.7904 9.6989 1.1786 20.707
NY GDSC2 5.901 11.7848 1.8105 11.4966
EW-1 GDSC2 5.9404 12.6771 1.4043 13.5695
EW-22 GDSC2 6.044 8.1266 3.5909 1.4324
EW-24 GDSC2 6.081 7.3549 3.9063 0.2735
CHSA8926 GDSC2 6.1762 7.9055 3.74 0.7153
SK-N-MC CTRP2 6.1962 7.4958 5.4409 2.2583
ES7 GDSC2 6.2579 9.7414 3.005 4.1027
HuO-3N1 GDSC2 6.3625 9.3086 3.2536 2.6552
CADO-ES1 GDSC2 6.4229 7.8268 3.8672 0.235
CAL-72 GDSC2 6.4248 8.1422 3.7541 0.515
EW-16 GDSC2 6.5178 8.7034 3.5792 1.0413
ES4 GDSC2 6.6465 8.6643 3.6496 0.7054
ES6 GDSC2 6.667 10.0218 3.1076 2.9822
CAL-78 GDSC2 6.6741 8.1821 3.8352 0.2201
EW-13 GDSC2 6.7186 8.6945 3.6679 0.607
SK-PN-DW GDSC2 6.7807 8.6951 3.6924 0.5053
ES8 GDSC2 6.8246 8.8051 3.6695 0.5463
EW-7 GDSC2 6.8449 8.3615 3.8347 0.1768
TC-71 GDSC2 6.9033 8.3534 3.8579 0.1312
EW-11 GDSC2 7.0005 10.0237 3.2734 1.8408
Hs 822.T CTRP2 7.0211 8.3824 5.554 0.7754
NOS-1 [Human HNSCC] GDSC2 7.0833 12.4048 2.2839 6.617
MG-63 GDSC2; CTRP2 7.1458 9.0661 5.3227 1.4536
H-EMC-SS GDSC2 7.2124 10.1696 3.3126 1.4906
U2OS GDSC2; CTRP2 7.4078 15.3811 2.4578 12.376
ES5 GDSC2 7.515 9.9502 3.5231 0.6067
TC71 CTRP2 7.5674 9.3493 5.4225 0.7688
EW-18 GDSC2 7.5704 9.4776 3.7101 0.204
G-292 clone A141B1 GDSC2; CTRP2 7.6676 9.633 5.3543 0.8993
HuO9 GDSC2 7.8506 9.6795 3.739 0.1196
MHH-ES-1 GDSC2; CTRP2 7.9481 9.7839 5.4236 0.5428
A-673 GDSC2; CTRP2 8.1287 9.3082 5.6668 0.0729
Hs 888.T CTRP2 8.1933 9.7767 5.5269 0.2374
SW1353 CTRP2 8.2924 9.5256 5.6503 0.0675
HOS GDSC2; CTRP2 8.3166 9.6628 5.6123 0.0988
SaOS-2 GDSC2; CTRP2 8.5646 10.3512 5.4627 0.2388
SJSA-1 CTRP2 8.6075 10.3369 5.4838 0.1982
SK-ES-1 GDSC2; CTRP2 8.9264 10.3835 5.5805 0.0569
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 190 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 5.3354 13.927 0.8432 17.6153
MEC1 CTRP2 7.9183 9.0189 5.6913 0.0783
JM1 CTRP2 6.1044 7.6712 5.2804 3.0975
TALL-1 [Human adult T-ALL] CTRP2 -1.7721 2.3672 -1.8706 48.718
BV-173 CTRP2 -1.3822 -0.6137 -1.3822 49.4768
DND-41 GDSC2; CTRP2 -1.0788 4.1151 -1.3003 47.6608
Reh GDSC2; CTRP2 0.2106 1.5982 0.2105 38.8659
SUP-T1 GDSC2; CTRP2 0.6171 3.5015 0.5757 36.2908
KE-37 GDSC2; CTRP2 0.7018 2.2987 0.7008 35.5964
P12-Ichikawa GDSC2; CTRP2 0.7885 2.631 0.7854 35.0258
CTV-1 GDSC2 1.1266 3.7589 0.9708 32.8307
RPMI-8402 CTRP2 1.131 2.7723 1.1289 32.7407
MOLT-13 GDSC2; CTRP2 1.2969 4.6957 1.1594 32.0831
MOLT-3 CTRP2 1.3085 2.3977 1.3085 31.5513
WIL2 NS GDSC2 1.9545 2.8909 1.9512 23.7738
CML-T1 GDSC2; CTRP2 2.3475 4.356 2.316 24.735
PF-382 GDSC2; CTRP2 2.3551 4.4497 2.3161 24.7096
HPB-ALL CTRP2 2.5029 5.838 2.0197 19.9955
CCRF-CEM GDSC2 2.6988 5.208 2.2489 18.7587
SUP-B15 GDSC2; CTRP2 2.9247 5.6559 2.7374 21.4306
697 GDSC2; CTRP2 3.0399 5.7601 2.8385 20.7138
P30/OHK GDSC2 3.2933 8.1465 1.4968 20.7365
NALM-6 GDSC2; CTRP2 3.8144 7.4737 3.1124 17.4343
RCH-ACV CTRP2 4.0014 6.6697 3.2561 10.5061
Jurkat GDSC2; CTRP2 4.1993 6.251 3.9708 13.0999
GDM-1 GDSC2 4.2251 7.0078 2.8974 9.2995
Kasumi-2 CTRP2 4.3913 6.7593 4.0048 12.4152
ALL-PO GDSC2 4.4102 7.9295 2.5912 10.6738
TUR GDSC2 4.5727 6.3011 3.5328 4.3133
JJN-3 GDSC2; CTRP2 4.6796 8.1556 3.7114 12.8016
P32/ISH GDSC2 4.8134 6.9507 3.3912 4.6079
ALL-SIL GDSC2; CTRP2 5.0323 8.8581 3.7253 11.8915
GA-10 GDSC2 5.0525 6.7915 3.6299 2.6571
BE-13 GDSC2 5.0563 7.0412 3.5148 3.3282
MHH-CALL-3 CTRP2 5.12 25.0983 -4.2634 33.4771
HAL-01 GDSC2 5.1282 10.4719 1.8903 12.9158
Karpas-231 GDSC2 5.1755 7.7284 3.2668 4.5675
KY821 GDSC2 5.2964 8.0745 3.1824 4.8228
PL21 CTRP2 5.311 12.3995 2.2367 17.2235
MOLT-16 GDSC2; CTRP2 5.3869 6.9997 4.3355 2.5502
MOLM-6 CTRP2 5.436 7.5727 4.0899 3.5532
Karpas-45 GDSC2 5.4689 8.6991 2.9996 5.5586
Peer CTRP2 5.6343 9.4889 3.9695 9.5436
DoHH2 GDSC2 5.6411 7.0461 3.8393 0.7676
TK [Human B-cell lymphoma] GDSC2 5.7473 7.4141 3.7403 1.0819
SKM-1 GDSC2 5.7567 6.9581 3.9235 0.3841
GR-ST GDSC2 5.8423 8.6833 3.2402 3.4878
SU-DHL-5 GDSC2 5.8488 7.0329 3.9328 0.3091
H9 GDSC2 5.8694 8.9505 3.1348 4.0272
LC4-1 GDSC2 5.9215 8.8985 3.1892 3.6386
MHH-CALL-2 GDSC2 5.9402 7.475 3.8042 0.659
Farage GDSC2 5.9746 7.7934 3.6938 1.0577
KMS-18 CTRP2 5.9807 7.9676 4.2698 1.9613
OCI-AML-2 GDSC2 5.9888 7.2894 3.8942 0.3452
Loucy GDSC2 6.0061 11.3544 2.091 9.7112
CESS GDSC2 6.0899 8.0429 3.647 1.1439
Raji GDSC2 6.0944 7.1772 3.9736 0.1337
IM-9 GDSC2 6.1007 7.3625 3.911 0.2546
NOMO-1 GDSC2 6.1211 7.689 3.7992 0.5535
SET-2 CTRP2 6.1427 7.5843 5.3547 2.7147
RS4;11 GDSC2; CTRP2 6.1641 8.0216 5.1537 3.5191
BL-41 GDSC2 6.1728 7.5339 3.8771 0.3057
Hs 445 GDSC2 6.205 7.767 3.8045 0.4875
SCC-3 GDSC2 6.2073 7.2944 3.9736 0.1087
ME1 GDSC2 6.226 7.8004 3.8006 0.4875
Karpas-1106P GDSC2 6.2827 8.1505 3.6914 0.8099
OPM-2 GDSC2 6.2876 7.9718 3.7617 0.5702
RC-K8 GDSC2 6.303 7.809 3.8281 0.3719
WSU-NHL GDSC2 6.3065 8.1354 3.7075 0.7362
Ramos.2G6.4C10 GDSC2 6.3253 7.5418 3.9308 0.1471
KMS-28BM CTRP2 6.3341 8.554 4.2122 1.7745
JVM-2 GDSC2 6.3423 8.8181 3.4508 1.7408
SR GDSC2 6.3559 7.9241 3.8069 0.4028
EM-2 GDSC2; CTRP2 6.3956 7.9061 5.3875 2.1525
A4/Fukuda GDSC2; CTRP2 6.4266 8.3304 5.2022 2.867
ATN-1 GDSC2 6.4449 8.0606 3.792 0.4003
RPMI-8866 GDSC2 6.4523 7.8966 3.8536 0.2532
Granta-519 GDSC2; CTRP2 6.4575 8.4128 5.1843 2.8917
SU-DHL-4 CTRP2 6.4764 7.8162 4.5933 0.397
DG-75 GDSC2 6.5009 8.3996 3.6889 0.6701
CA46 GDSC2; CTRP2 6.5083 8.0748 5.385 1.9939
MHH-CALL-4 CTRP2 6.5206 8.372 4.3903 0.9619
RPMI-8226 GDSC2 6.5285 8.2885 3.7416 0.4958
NU-DHL-1 CTRP2 6.5375 8.5937 5.1537 2.8927
OCI-AML-3 GDSC2; CTRP2 6.5536 11.1669 3.8941 8.0936
MOLT-4 GDSC2 6.5551 7.9683 3.8662 0.1973
MC116 CTRP2 6.5588 7.3134 4.8042 0.0296
SU-DHL-8 GDSC2; CTRP2 6.5646 8.273 4.4523 0.7347
BALL-1 GDSC2 6.5671 8.194 3.791 0.3499
JSC-1 GDSC2 6.5881 8.6028 3.6484 0.7462
WSU-DLCL2 CTRP2 6.6107 8.0776 5.4522 1.5849
KOPN-8 GDSC2 6.6139 8.4729 3.7078 0.5474
KCL-22 GDSC2; CTRP2 6.6179 8.4733 5.2683 2.3073
MHH-PREB-1 GDSC2 6.6255 8.1384 3.8326 0.2393
Hs 611.T CTRP2 6.6361 8.3894 5.3209 2.0709
Mino CTRP2 6.6386 9.1037 4.9772 3.4608
L-363 GDSC2 6.6478 8.5511 3.6925 0.5736
HC-1 GDSC2 6.6547 8.326 3.7772 0.3474
Karpas-299 GDSC2 6.6609 8.5434 3.7006 0.5432
U-698-M GDSC2 6.694 8.63 3.6819 0.5794
MOLM-13 GDSC2 6.6982 8.6175 3.6882 0.5589
ST486 GDSC2; CTRP2 6.7093 8.4104 5.359 1.8221
MEG-01 GDSC2 6.7353 8.6854 3.678 0.5686
SU-DHL-10 GDSC2; CTRP2 6.7426 7.5905 4.7746 0.0336
Mono-Mac-6 CTRP2 6.7659 11.0425 3.33 4.7976
ARH-77 GDSC2 6.7659 8.3477 3.811 0.2384
KMS-26 CTRP2 6.8062 8.1083 5.5569 0.9639
VL51 GDSC2 6.851 8.7651 3.6945 0.4668
ML-2 GDSC2 6.8611 8.5262 3.7835 0.2621
Jiyoye GDSC2 6.8856 8.8673 3.6709 0.5127
KMOE-2 GDSC2 6.8912 8.6896 3.7371 0.3483
KMS-20 CTRP2 6.8915 9.1494 5.1284 2.4895
DB GDSC2; CTRP2 6.9159 8.9026 5.2598 1.9464
AMO1 GDSC2; CTRP2 6.9316 7.9811 4.7087 0.065
MOTN-1 CTRP2 6.9602 9.2985 5.1026 2.5007
SIG-M5 CTRP2 6.9603 8.012 5.6786 0.4388
KMS-12-BM GDSC2; CTRP2 6.9827 8.29 4.6207 0.1603
MLMA GDSC2 6.9836 9.065 3.6372 0.5558
EB2 GDSC2 6.9985 8.6152 3.8023 0.1918
VAL GDSC2 7.0045 8.7411 3.7609 0.2619
Karpas-422 GDSC2; CTRP2 7.0087 9.0382 5.2544 1.856
MN-60 GDSC2 7.05 8.9481 3.705 0.3609
BL-70 CTRP2 7.0528 8.2787 5.6137 0.5646
SEM CTRP2 7.13 8.5832 5.5248 0.7802
L-1236 GDSC2; CTRP2 7.1355 9.4811 5.1278 2.186
M-07e CTRP2 7.2143 11.3032 4.3146 5.2973
Ci-1 CTRP2 7.2216 15.1047 2.454 12.7058
KG-1 GDSC2 7.2285 8.9858 3.7571 0.2092
OCI-Ly10 CTRP2 7.2563 10.634 4.664 3.8376
MOLP-2 CTRP2 7.2655 9.0001 5.4173 1.0153
HEL 92.1.7 CTRP2 7.2685 8.8892 5.4661 0.8557
KHM-1B CTRP2 7.2762 8.8305 5.4946 0.7612
AML-193 CTRP2 7.2851 8.4271 5.6608 0.3043
MOLM-16 CTRP2 7.3054 8.6701 4.6058 0.1148
P3HR-1 CTRP2 7.3234 8.8353 4.555 0.1758
A3/Kawakami GDSC2; CTRP2 7.3325 8.2377 5.7499 0.1179
BC-1 GDSC2 7.3329 8.9011 3.822 0.1046
Ku812 GDSC2; CTRP2 7.3393 11.3547 4.3754 4.8729
RL CTRP2 7.407 11.4575 4.3719 4.7926
L-540 GDSC2; CTRP2 7.4343 9.1027 4.5019 0.228
SUP-M2 GDSC2; CTRP2 7.4415 8.5433 5.6816 0.1999
CMK CTRP2 7.4487 8.438 5.7225 0.1297
JeKo-1 CTRP2 7.4907 11.7673 4.28 5.0426
SUP-T11 CTRP2 7.5263 9.1078 4.5341 0.1609
Daudi GDSC2; CTRP2 7.6145 9.2743 5.475 0.5932
HT CTRP2 7.6438 8.6966 5.7038 0.1114
RPMI-6666 GDSC2; CTRP2 7.6508 9.1101 5.5551 0.3774
TF-1 CTRP2 7.6865 8.6706 5.7282 0.0753
SU-DHL-1 CTRP2 7.7059 8.7058 5.7231 0.0777
OCI-M1 GDSC2; CTRP2 7.708 8.8366 5.6784 0.1316
SU-DHL-6 GDSC2; CTRP2 7.7158 9.2409 4.5559 0.1045
OCI-AML-5 GDSC2; CTRP2 7.7318 8.7306 5.7238 0.0731
HD-MY-Z CTRP2 7.7603 9.7403 5.3551 0.8336
DEL GDSC2; CTRP2 7.7653 8.7372 5.7333 0.0596
HuNS1 CTRP2 7.8065 9.4928 5.4748 0.4903
REC-1 CTRP2 7.8193 9.7507 4.4166 0.2615
KM-H2 GDSC2; CTRP2 7.8518 10.8264 4.9387 2.1069
SUP-HD1 GDSC2; CTRP2 7.8737 12.1373 4.354 4.2508
KO52 CTRP2 7.8979 8.9245 5.7161 0.0584
U266B1 GDSC2; CTRP2 7.9022 9.9488 5.3375 0.7917
KMS-27 CTRP2 7.9055 9.1448 5.6432 0.1361
K-562 GDSC2; CTRP2 7.9582 9.4889 5.5395 0.2884
L-428 GDSC2; CTRP2 7.9591 9.517 5.5295 0.3071
OCI-Ly3 CTRP2 7.9939 9.5875 5.5174 0.3179
Karpas-620 GDSC2; CTRP2 8.0077 9.3876 5.5955 0.1797
HL-60 GDSC2; CTRP2 8.017 9.0712 5.7079 0.0519
HEL GDSC2; CTRP2 8.0338 9.38 5.6079 0.1557
Namalwa GDSC2; CTRP2 8.0547 9.5209 5.5657 0.2134
EHEB CTRP2 8.0917 10.5597 5.1785 1.121
Ri-1 CTRP2 8.1308 10.352 4.3201 0.3328
LP-1 GDSC2; CTRP2 8.151 9.7282 5.528 0.2476
KE-97 CTRP2 8.1874 9.8688 5.4911 0.3008
Ki-JK CTRP2 8.1876 9.8183 5.5096 0.268
MOLP-8 GDSC2; CTRP2 8.1952 9.6171 5.5843 0.1526
OCI-Ly19 CTRP2 8.2354 9.9786 5.4698 0.3239
LAMA-84 GDSC2; CTRP2 8.2706 10.0533 5.4563 0.3369
SK-MM-2 GDSC2; CTRP2 8.2724 9.9089 5.5097 0.2431
NCI-H929 GDSC2; CTRP2 8.3425 9.7154 5.6035 0.1039
JURL-MK1 GDSC2; CTRP2 8.3519 9.7993 5.5779 0.1302
EJM GDSC2; CTRP2 8.39 10.0624 5.4995 0.2275
EoL-1 GDSC2; CTRP2 8.4018 10.1257 5.4814 0.2528
HH [Human lymphoma] GDSC2; CTRP2 8.4782 15.6761 3.0747 8.387
HuT 78 CTRP2 8.4953 10.4925 5.3842 0.3952
KMS-21-BM CTRP2 8.512 10.184 5.5022 0.1943
HDLM-2 GDSC2; CTRP2 8.5629 10.2539 5.4965 0.1908
JVM-3 GDSC2; CTRP2 8.5681 10.1253 5.5431 0.1323
Mono-Mac-1 CTRP2 8.6889 10.9689 4.3098 0.2177
MM1.S GDSC2; CTRP2 8.7068 9.9917 5.636 0.0408
F-36P CTRP2 8.9028 10.7293 5.4549 0.1751
Kasumi-1 GDSC2; CTRP2 9.0298 10.7274 5.5008 0.1069
⏷ Show the Full List of 190 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 6.9568 8.7978 5.3333 1.6192
TE8 CTRP2 8.6455 10.1775 5.5528 0.11
KYSE-270 GDSC2 5.6427 12.5855 1.2325 15.1604
OE19 GDSC2; CTRP2 6.4041 8.1094 4.4419 0.8861
TE-15 GDSC2 6.5369 10.2918 2.9183 4.1337
TE-8 GDSC2 7.1811 9.5407 3.5407 0.7269
OE33 GDSC2; CTRP2 7.424 10.0118 4.1524 1.0468
TE-9 GDSC2; CTRP2 7.7902 9.0614 5.6294 0.1841
KYSE-150 CTRP2 7.8525 10.7857 4.957 2.0421
KYSE-30 CTRP2 7.9102 9.3422 5.5743 0.2411
KYSE-450 GDSC2; CTRP2 8.0307 21.3359 -0.0157 19.5211
KYSE-520 GDSC2; CTRP2 8.1965 10.1352 4.4205 0.1744
TE-6 GDSC2; CTRP2 8.2383 9.8376 5.5222 0.2324
TE-5 GDSC2; CTRP2 8.2691 9.8419 5.5324 0.2086
KYSE-140 GDSC2; CTRP2 8.2865 10.5809 5.2613 0.7685
TE-4 GDSC2; CTRP2 8.3207 9.9688 5.5067 0.2347
TE-11 CTRP2 8.3895 10.1737 5.4592 0.2932
TE-14 CTRP2 8.4198 10.1621 5.4752 0.2578
EC-GI-10 GDSC2; CTRP2 8.4383 10.1355 5.4917 0.227
KYSE-410 GDSC2; CTRP2 8.4817 10.1854 5.4904 0.2182
OE21 GDSC2; CTRP2 8.549 10.2994 5.4752 0.224
KYSE-70 GDSC2; CTRP2 8.5591 9.959 5.5966 0.0812
KYSE-510 GDSC2; CTRP2 8.598 9.9106 5.6262 0.055
KYSE-180 GDSC2; CTRP2 8.7266 10.4735 5.4798 0.1784
TE-1 GDSC2; CTRP2 8.7427 10.5238 5.4681 0.1902
TE-10 CTRP2 8.7529 10.4158 5.5093 0.1388
COLO 680N GDSC2; CTRP2 8.8055 10.2039 5.5991 0.055
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 9.9298 15.7636 3.9133 3.6684
KP-2 GDSC2; CTRP2 5.451 9.4327 3.8335 10.5015
PaTu 8988t GDSC2; CTRP2 6.5418 7.7191 5.5764 1.1888
Panc 02.03 GDSC2 6.5524 8.5102 3.6686 0.7033
PL4 GDSC2 6.8343 8.3449 3.8365 0.1763
PSN1 GDSC2; CTRP2 6.9439 8.6476 5.3941 1.4084
DAN-G GDSC2; CTRP2 7.2939 10.1425 4.9194 2.791
PK-45H CTRP2 7.4013 9.1165 4.4845 0.2657
SNU-410 CTRP2 7.4163 9.1496 4.4783 0.2718
SU.86.86 GDSC2; CTRP2 7.4682 8.7341 5.6212 0.3112
KP-1N GDSC2 7.5333 9.6163 3.6489 0.3162
PaTu 8902 GDSC2; CTRP2 7.6531 10.8215 4.8261 2.723
L3.3 CTRP2 7.6829 9.2915 5.4989 0.4943
KP-4 GDSC2; CTRP2 7.83 8.9665 5.6777 0.1075
Panc 04.03 CTRP2 7.8378 9.5825 5.4536 0.5257
YAPC GDSC2; CTRP2 7.9508 9.0476 5.6929 0.0722
SUIT-2 GDSC2; CTRP2 7.9589 9.3576 5.5876 0.2045
Panc 03.27 CTRP2 8.1197 9.7207 5.5185 0.2735
SNU-213 CTRP2 8.1259 9.2416 5.6882 0.0557
AsPC-1 GDSC2; CTRP2 8.1801 10.1039 5.4001 0.4878
Panc 05.04 CTRP2 8.1898 9.8596 5.4954 0.2923
MIA PaCa-2 GDSC2; CTRP2 8.2266 9.4271 5.6607 0.0665
Capan-2 GDSC2; CTRP2 8.2566 10.3592 5.3348 0.6023
HuP-T3 GDSC2; CTRP2 8.2573 10.0407 5.4556 0.3429
Capan-1 GDSC2; CTRP2 8.3081 9.7585 5.5762 0.1402
QGP-1 GDSC2; CTRP2 8.3399 9.8556 5.554 0.162
Panc 08.13 GDSC2; CTRP2 8.3507 10.2955 5.3988 0.4202
Panc 10.05 GDSC2; CTRP2 8.4393 14.0103 3.8365 5.5307
SW1990 CTRP2 8.4405 10.5208 5.3512 0.4831
BxPC-3 GDSC2; CTRP2 8.5358 10.0982 5.5409 0.1404
HPAF-II GDSC2; CTRP2 8.5482 10.1259 5.5358 0.1442
PK-59 CTRP2 8.5777 10.026 5.5805 0.0931
TCC-Pan2 CTRP2 8.5978 9.8991 5.6299 0.0526
HPAC GDSC2; CTRP2 8.6349 9.8374 5.6626 0.0319
Hs 766T CTRP2 8.6987 10.3692 5.5059 0.152
HuP-T4 GDSC2; CTRP2 8.845 10.5194 5.5066 0.1271
KP-3 GDSC2; CTRP2 8.9423 10.8242 5.4363 0.1904
PaTu 8988s CTRP2 9.7914 21.5368 1.1546 13.2972
CFPAC-1 GDSC2; CTRP2 14.5775 33.2458 -1.2737 14.229
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 61 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 7.7582 10.0074 4.2994 0.4983
WM88 CTRP2 5.8237 7.1419 5.3024 3.5724
CP66-MEL GDSC2 5.9501 7.2794 3.8824 0.3983
Mel JuSo GDSC2 6.0101 8.798 3.285 2.985
GAK GDSC2 6.292 7.6258 3.8895 0.2328
HMCB CTRP2 6.384 7.8012 5.4304 1.9947
G-mel GDSC2 6.3874 8.3007 3.6786 0.7795
WM1552C GDSC2 6.3878 8.3112 3.6748 0.7925
COLO 679 GDSC2 6.5202 8.2709 3.7448 0.4912
WM35 GDSC2 6.5367 8.8397 3.5339 1.2
M14 GDSC2 6.5633 8.4331 3.7021 0.5922
LOX-IMVI GDSC2; CTRP2 6.5658 7.8061 5.5509 1.2574
Hs 944.T CTRP2 6.592 8.2223 4.4854 0.62
Malme-3M CTRP2 6.6012 9.9783 4.52 5.4097
HMV-II GDSC2 6.6431 8.8549 3.5752 0.9597
COLO 792 GDSC2; CTRP2 6.6658 9.5489 4.7791 4.2322
CHL-1 GDSC2 6.6664 8.5175 3.7123 0.5075
SK-MEL-28 CTRP2 6.7451 8.2031 5.478 1.3198
IGR-39 CTRP2 6.8567 9.8917 4.7484 4.065
SH-4 GDSC2 6.8967 8.6725 3.7452 0.3286
RPMI-7951 GDSC2; CTRP2 6.948 9.3783 5.057 2.6959
Hs 936.T CTRP2 6.9606 9.4154 5.0476 2.7163
WM278 GDSC2 7.0866 9.1555 3.6446 0.4886
Hs 934.T CTRP2 7.0956 10.8982 4.4279 5.0131
SK-MEL-3 CTRP2 7.1431 8.6589 5.4994 0.851
A101D GDSC2; CTRP2 7.1719 8.465 5.5947 0.5385
Hs 839.T CTRP2 7.1744 9.662 5.0681 2.3668
K029AX CTRP2 7.1852 8.4903 4.6247 0.1138
SK-MEL-2 GDSC2; CTRP2 7.1916 8.1433 5.7291 0.1972
UACC-62 GDSC2; CTRP2 7.2127 8.9655 5.4042 1.1053
IPC-298 CTRP2 7.2216 8.647 5.544 0.6521
COLO 800 CTRP2 7.2458 9.2158 4.3852 0.527
WM983B CTRP2 7.2716 10.5767 4.7013 3.6695
Hs 688(A).T CTRP2 7.3548 8.6919 5.5882 0.4453
A2058 GDSC2; CTRP2 7.3676 8.3185 5.7344 0.1325
WM266-4 CTRP2 7.3691 8.213 5.7721 0.08
CJM [Human melanoma] CTRP2 7.4533 8.7081 5.6248 0.3098
UACC-257 GDSC2; CTRP2 7.4696 9.3234 5.3851 0.9525
Hs 852.T CTRP2 7.507 12.1254 4.1195 5.6598
IGR-1 GDSC2; CTRP2 7.6338 9.1546 5.5307 0.4421
SK-MEL-1 CTRP2 7.6798 8.8041 5.6793 0.1368
Hs 895.T CTRP2 7.6845 9.8969 5.2523 1.2015
WM115 GDSC2; CTRP2 7.7265 8.9313 5.6517 0.1661
IGR-37 GDSC2; CTRP2 7.7535 8.8613 5.6865 0.1114
SK-MEL-30 CTRP2 7.7943 8.8565 5.7029 0.0851
MDA-MB-435S CTRP2 7.8057 8.9321 5.6809 0.1083
Mel Ho CTRP2 7.8492 9.5624 5.4663 0.4894
G-361 GDSC2; CTRP2 7.8546 9.1382 5.6264 0.1717
MeWo CTRP2 7.8899 9.9188 5.3438 0.7818
RVH-421 CTRP2 7.9048 9.5094 5.5101 0.3667
Hs 940.T CTRP2 7.9248 9.6786 5.4541 0.4818
WT2-iPS GDSC2; CTRP2 7.9759 9.1465 5.668 0.0933
SK-MEL-31 CTRP2 8.0452 9.517 5.5634 0.2197
Hs 294T CTRP2 8.0723 9.2843 5.6551 0.0919
WM793 GDSC2; CTRP2 8.1047 9.2502 5.678 0.0661
WM1799 CTRP2 8.1489 9.4003 5.6426 0.0931
A-375 GDSC2; CTRP2 8.1937 9.4146 5.6535 0.0765
HT-144 GDSC2; CTRP2 8.1941 9.9384 5.4681 0.3414
SK-MEL-5 GDSC2; CTRP2 8.3449 9.411 5.7059 0.0281
COLO 829 GDSC2; CTRP2 8.408 10.4007 5.3829 0.4302
SK-MEL-24 GDSC2; CTRP2 8.7905 10.1787 5.6024 0.0542
⏷ Show the Full List of 61 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC2 5.4791 10.1586 2.3027 9.6718
ESO-26 GDSC2 5.5551 7.5725 3.5729 2.137
TE-12 GDSC2 6.2389 14.613 0.6734 16.432
KYSE-50 GDSC2 6.5824 11.6246 2.3384 7.1956
KYSE-220 GDSC2 6.7331 8.5325 3.733 0.4215
OACP4 C GDSC2 6.9708 9.3343 3.5314 0.8828
SK-GT-4 GDSC2 6.9814 16.9482 0.0644 17.4051
KYAE-1 GDSC2 7.0902 8.6626 3.8185 0.1485
OACM5.1 C GDSC2 7.3025 9.5322 3.592 0.526
FLO-1 GDSC2 7.437 9.7808 3.5541 0.5622
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 7.1674 9.1764 3.668 0.3995
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB(TU)1 GDSC2 5.8607 7.4834 3.7655 0.8693
IMR-5 GDSC2 5.9285 8.1164 3.5371 1.8153
SJNB-14 GDSC2 6.2586 7.995 3.7408 0.6559
TGW GDSC2 6.3175 7.8384 3.8231 0.3782
CHP-126 CTRP2 6.3272 8.5418 4.2137 1.7763
SJNB-10 GDSC2 6.3476 8.123 3.7296 0.6353
SJNB-7 GDSC2 6.3889 8.0379 3.7782 0.4649
CHP-134 GDSC2 6.47 8.0868 3.7923 0.3882
SK-N-BE(2)-M17 GDSC2 6.5526 8.384 3.716 0.5566
Kelly GDSC2 6.6473 7.9733 3.8973 0.1271
SJNB-13 GDSC2 6.6542 8.5506 3.6952 0.5622
SiMa GDSC2 6.7656 8.7526 3.6653 0.589
GOTO GDSC2 6.8074 9.0169 3.5833 0.818
NH-12 GDSC2 6.8547 8.4988 3.7907 0.2502
GI-ME-N GDSC2 6.9069 9.4694 3.4516 1.2106
CHP-212 GDSC2; CTRP2 7.0116 9.4766 5.0519 2.6326
NB69 GDSC2 7.1103 8.9607 3.723 0.3028
IMR-32 CTRP2 7.21 8.3831 5.645 0.3799
SK-N-SH CTRP2 7.3504 11.8685 4.1358 5.8196
SK-N-FI CTRP2 7.7437 14.0881 3.3356 8.4354
SK-N-AS GDSC2; CTRP2 7.8872 9.6073 5.4654 0.4733
KP-N-YN GDSC2; CTRP2 7.9486 10.4104 5.1698 1.253
SK-N-DZ GDSC2; CTRP2 8.0922 9.2138 5.686 0.061
SK-N-BE(2) CTRP2 8.1657 10.1596 5.3726 0.5572
NH-6 CTRP2 8.2571 9.7063 5.5758 0.1508
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 7.5438 9.4349 5.3756 0.9254
HuCC-T1 GDSC2; CTRP2 7.7221 9.6014 5.3934 0.7498
HuH-28 CTRP2 7.8281 9.1221 5.6221 0.1854
SNU-869 CTRP2 7.9264 9.8282 5.3966 0.6208
SNU-308 CTRP2 8.1114 9.4852 5.5996 0.15
SNU-1196 CTRP2 8.3824 9.8671 5.5655 0.1393
SNU-478 CTRP2 8.5257 9.9226 5.5974 0.0846
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 83 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-157 GDSC2; CTRP2 5.3203 9.5999 3.6322 11.6206
HCC2157 GDSC2 6.0868 7.6898 3.7845 0.6243
MDA-MB-415 GDSC2 6.1271 11.028 2.3276 8.1281
AU565 GDSC2 6.1603 8.7425 3.3904 2.2401
MRK-nu-1 GDSC2 6.2838 7.537 3.9175 0.1807
Evsa-T GDSC2 6.4327 7.6308 3.9383 0.1129
HCC1187 GDSC2 6.529 8.0556 3.826 0.285
T-47D GDSC2; CTRP2 6.5583 8.5132 5.2076 2.6406
COLO 824 GDSC2 6.581 8.4976 3.6852 0.6334
MDA-MB-453 GDSC2 6.6042 8.4338 3.7183 0.5225
MDA-MB-436 GDSC2 6.7203 9.7691 3.2421 2.274
HCC70 GDSC2 6.7734 8.434 3.7835 0.2903
OCUB-M GDSC2 6.7771 8.4814 3.7681 0.3217
KPL-1 CTRP2 6.7921 7.7863 5.6894 0.5283
MFM-223 GDSC2 6.8361 8.241 3.8725 0.1245
EFM-19 GDSC2 6.8594 9.1761 3.5446 0.9129
MDA-MB-330 GDSC2 6.8895 12.2387 2.2436 7.1596
CAL-148 CTRP2 6.9654 8.6895 5.3877 1.4084
HCC1569 GDSC2 7.0272 9.4448 3.5131 0.9063
MDA-MB-231 GDSC2 7.2557 9.1128 3.723 0.2596
HCC38 GDSC2; CTRP2 7.3987 9.1226 4.4813 0.2719
BT-549 GDSC2; CTRP2 7.4226 8.9359 4.5562 0.1532
HMC-1-8 CTRP2 7.6104 8.8668 5.6298 0.2387
EFM-192A GDSC2; CTRP2 7.632 11.9631 4.2806 4.8483
CAL-120 GDSC2; CTRP2 7.6704 8.9972 5.6058 0.2635
ZR-75-1 CTRP2 7.7256 9.181 5.5596 0.3356
MDA-MB-468 GDSC2; CTRP2 7.7261 9.4483 5.4565 0.5779
HCC1500 GDSC2; CTRP2 7.7334 9.3534 5.497 0.4734
JIMT-1 GDSC2; CTRP2 7.768 9.1365 5.5934 0.2528
DU4475 GDSC2; CTRP2 7.9184 8.9313 5.7209 0.0523
MDA-MB-361 GDSC2; CTRP2 8.1231 9.9573 5.4319 0.4429
HCC2218 CTRP2 8.1345 10.1202 5.3743 0.5683
Hs 578T GDSC2; CTRP2 8.1502 9.8772 5.4731 0.3476
HCC1419 GDSC2; CTRP2 8.2032 9.4615 5.6409 0.087
CAMA-1 GDSC2; CTRP2 8.2307 9.9424 5.4812 0.3045
CAL-85-1 GDSC2; CTRP2 8.2962 10.4601 5.313 0.6349
HCC1806 GDSC2; CTRP2 8.303 9.6685 5.6055 0.1079
BT-474 GDSC2; CTRP2 8.374 9.6158 5.6481 0.0606
HDQ-P1 GDSC2; CTRP2 8.406 10.0406 5.5133 0.203
CAL-51 GDSC2; CTRP2 8.4635 10.17 5.489 0.2247
HCC1954 GDSC2; CTRP2 8.4963 11.2575 5.0871 1.1125
SK-BR-3 CTRP2 8.5152 10.2949 5.464 0.2496
HCC1937 GDSC2; CTRP2 8.5193 10.1717 5.5093 0.1831
BT-20 GDSC2; CTRP2 8.5686 10.2303 5.5069 0.1759
MCF-7 GDSC2; CTRP2 8.6419 10.3802 5.4813 0.194
HCC1428 GDSC2; CTRP2 8.7476 20.0816 0.3432 13.4582
HCC1395 CTRP2 8.8117 10.3002 5.5692 0.0753
HCC1143 GDSC2; CTRP2 9.1967 11.2553 5.3789 0.2121
ZR-75-30 GDSC2; CTRP2 13.5084 29.2151 -0.0694 12.3521
BT 179 CTRP2 6.4621 7.6643 4.645 0.2821
BT 239 CTRP2 6.8843 8.6686 5.3486 1.6456
BT 145 CTRP2 7.1123 8.3168 4.6581 0.089
BT164 CTRP2 7.1487 8.3752 4.6511 0.0908
BT 498 CTRP2 7.1514 8.2787 5.6599 0.3739
BT 232 CTRP2 7.1559 9.1525 5.2898 1.5616
BT 112 CTRP2 7.216 8.2539 4.7146 0.0338
BT 224 CTRP2 7.296 8.4736 4.6689 0.0569
BT 320 CTRP2 7.3128 8.2793 5.7274 0.1595
BT 422 CTRP2 7.4265 8.5176 5.6851 0.1985
BT 271 CTRP2 7.4547 10.2299 4.9774 2.3832
BT 228 CTRP2 7.5002 8.7959 5.6112 0.3194
BT 504 CTRP2 7.5143 9.436 5.3603 0.9952
BT147 CTRP2 7.5263 9.4217 5.3724 0.9484
BT 231 CTRP2 7.5542 9.4764 5.3634 0.9548
BT 139 CTRP2 7.6944 9.1424 5.5612 0.3452
BT 159 CTRP2 7.7668 9.1503 5.5879 0.2636
BT 216 CTRP2 7.7961 9.3662 5.5189 0.3935
BT 330 CTRP2 7.8042 9.1101 5.6172 0.1999
BT 444 CTRP2 7.8123 8.7884 5.7323 0.0548
BT 248 CTRP2 7.8141 9.6304 5.4242 0.6121
BT 340 CTRP2 7.8166 8.9792 5.6684 0.1216
BT 416 CTRP2 7.83 9.0411 5.6517 0.1411
BT 172 CTRP2 7.8767 9.7301 5.413 0.6064
BT 482 CTRP2 7.967 9.4515 5.5567 0.2542
BT 328 CTRP2 7.9861 9.208 5.6505 0.1112
BT 333 CTRP2 8.0226 9.3056 5.6299 0.1292
BT 245 CTRP2 8.043 10.1012 5.3412 0.6984
BT 359 CTRP2 8.1792 10.0031 5.4379 0.4072
BT 428 CTRP2 8.3155 9.9718 5.5036 0.241
BT 286 CTRP2 8.3917 9.7565 5.6068 0.0934
BT 440 CTRP2 8.5909 9.8639 5.6392 0.0473
BT 187 CTRP2 8.6279 10.5048 5.4318 0.2699
BT 131 CTRP2 12.366 28.0638 -0.2482 14.1026
⏷ Show the Full List of 83 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 7.1754 8.8419 5.4378 1.0259
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-392MG GDSC2 5.2538 8.3067 3.0425 5.7532
D-263MG GDSC2 6.0605 7.7211 3.7611 0.7243
H4 GDSC2 6.2797 14.0337 0.9851 14.8816
AM-38 GDSC2 6.3046 8.0963 3.7216 0.6896
TM-31 CTRP2 6.4018 7.8324 5.4279 1.9774
GI-1 GDSC2 6.4244 8.2717 3.7054 0.6652
KS-1 [Human Krukenberg tumour] GDSC2 6.6251 9.9652 3.1098 3.0259
DK-MG GDSC2; CTRP2 6.6973 7.9437 4.636 0.214
SK-MG-1 GDSC2 6.7297 8.2414 3.8347 0.2055
M059J GDSC2 6.7338 8.4972 3.746 0.3893
KINGS-1 GDSC2 6.7376 13.9799 1.3275 12.2151
LN-405 GDSC2 6.8456 8.4822 3.7932 0.2483
GOS-3 CTRP2 7.0019 16.0098 1.8354 15.378
CCF-STTG1 CTRP2 7.0085 8.3888 4.5954 0.1925
PFSK-1 GDSC2 7.016 8.7936 3.7468 0.2856
NMC-G1 CTRP2 7.046 8.3667 5.5735 0.6929
LN-18 GDSC2; CTRP2 7.1606 8.8171 5.4406 1.0295
SNU-466 CTRP2 7.2255 8.361 5.6605 0.3336
GMS-10 CTRP2 7.2531 8.6968 5.5387 0.6455
SF268 GDSC2; CTRP2 7.2738 9.7774 5.0757 2.2214
SNU-626 CTRP2 7.2897 8.5092 5.631 0.3728
CAS-1 GDSC2; CTRP2 7.2932 8.5707 5.6084 0.4277
SNU-489 CTRP2 7.3281 8.7544 5.551 0.5606
GaMG GDSC2; CTRP2 7.4945 9.1427 5.4721 0.6752
KG-1-C CTRP2 7.5078 8.786 5.6181 0.3012
SF539 GDSC2; CTRP2 7.5091 9.7786 5.2103 1.4925
8-MG-BA GDSC2; CTRP2 7.5256 9.4863 5.3448 1.0349
SW1783 CTRP2 7.5725 9.5083 5.3592 0.9541
U-87MG ATCC GDSC2; CTRP2 7.6054 8.7224 5.6804 0.1536
KNS-60 CTRP2 7.616 8.8831 5.6261 0.2439
42-MG-BA GDSC2; CTRP2 7.6296 9.3046 5.4698 0.5982
KNS-81 CTRP2 7.664 8.9274 5.6289 0.2225
SNU-738 CTRP2 7.7491 8.9094 5.668 0.1368
SNU-201 CTRP2 7.7593 9.0498 5.6216 0.2056
M059K CTRP2 7.8405 10.1231 5.236 1.1307
D283 Med GDSC2; CTRP2 7.8556 9.3382 5.554 0.2969
SNU-1105 CTRP2 7.9095 9.0742 5.6692 0.1031
U-251MG GDSC2; CTRP2 7.9937 9.6219 5.5045 0.3434
YKG-1 CTRP2 8.0243 9.3582 5.6121 0.1522
Becker GDSC2; CTRP2 8.0533 9.4113 5.6041 0.1566
U-118MG GDSC2; CTRP2 8.0851 9.5078 5.5819 0.1807
T98G GDSC2; CTRP2 8.1444 13.3176 3.9735 5.3768
Daoy GDSC2; CTRP2 8.1731 9.6626 5.56 0.1914
YH-13 GDSC2; CTRP2 8.1772 9.6751 5.5571 0.1946
KNS-42 CTRP2 8.1804 9.9863 5.4447 0.3928
A-172 GDSC2; CTRP2 8.2466 9.9067 5.5005 0.2658
SF295 CTRP2 8.2829 9.3935 5.691 0.04
ONS-76 GDSC2; CTRP2 8.3068 9.5429 5.6494 0.0666
Hs 683 CTRP2 8.326 9.6226 5.6292 0.0814
SF126 CTRP2 8.3779 9.6177 5.6488 0.0597
GB-1 GDSC2; CTRP2 8.6154 9.884 5.6408 0.0445
SW1088 GDSC2; CTRP2 8.6656 10.3764 5.4914 0.176
KALS-1 GDSC2; CTRP2 8.7097 10.6026 5.428 0.2544
DBTRG-05MG GDSC2; CTRP2 8.7144 10.3475 5.5191 0.1345
SNB-75 CTRP2 8.7987 12.696 4.6365 2.2681
LN-229 GDSC2; CTRP2 8.973 10.3866 5.5951 0.045
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 6.8583 8.7713 3.6951 0.462
TGBC24TKB GDSC2 7.2072 9.1924 3.6773 0.3646
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC2; CTRP2 7.3484 8.9738 5.4707 0.7805
MFE-280 GDSC2 7.6141 10.3923 3.3996 0.9055
JHUEM-1 CTRP2 7.7475 8.7762 5.7138 0.081
HEC-251 CTRP2 7.8455 9.3784 5.5349 0.339
HEC-265 CTRP2 7.8811 9.0003 5.6845 0.0909
MFE-319 GDSC2; CTRP2 7.9025 9.3022 5.5858 0.2236
HEC-1-B CTRP2 7.9062 9.6116 5.4719 0.4496
EFE-184 CTRP2 7.973 9.7175 5.4599 0.4466
HEC-151 CTRP2 8.0113 10.6503 5.1005 1.4215
EN GDSC2; CTRP2 8.0225 9.3108 5.628 0.1316
HEC-6 CTRP2 8.0814 9.301 5.6526 0.0931
HEC-59 CTRP2 8.1302 9.5577 5.5811 0.1712
JHUEM-2 CTRP2 8.2141 10.1904 5.3815 0.5142
MFE-296 GDSC2; CTRP2 8.2938 10.421 5.3271 0.6026
HEC-108 CTRP2 8.3381 9.4268 5.6985 0.0321
RL95-2 GDSC2; CTRP2 8.3753 9.513 5.6826 0.038
AN3-CA GDSC2; CTRP2 8.614 10.1902 5.5373 0.1311
KLE GDSC2; CTRP2 8.6203 10.3548 5.4823 0.1975
HEC-1-A CTRP2 8.7417 10.551 5.4582 0.2035
HEC-50B CTRP2 13.5593 33.1929 -2.7248 15.8695
Ishikawa (Heraklio) 02 ER- CTRP2 7.4971 8.6175 5.6764 0.1913
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SN12C GDSC2 6.2176 8.0734 3.6929 0.8539
KTCTL-195 GDSC2 6.2506 13.2554 1.3425 13.1818
TUHR10TKB CTRP2 6.3622 7.6698 4.6003 0.4403
SW13 GDSC2 6.6092 8.2311 3.7938 0.3268
LB996-RCC GDSC2 6.6947 9.3539 3.4007 1.5992
TUHR4TKB CTRP2 6.7808 10.3927 4.4493 5.4094
A-704 GDSC2 6.8213 8.382 3.8192 0.2081
HA7-RCC GDSC2 6.9735 8.9976 3.6579 0.5057
NCC010 GDSC2 7.2051 9.2207 3.6665 0.3889
RCC10RGB GDSC2; CTRP2 7.2197 9.0833 5.3566 1.2615
RXF 393L GDSC2 7.3265 10.1776 3.36 1.2252
Caki-2 CTRP2 7.3349 9.9682 5.0251 2.3411
TUHR14TKB CTRP2 7.3595 12.2148 3.9746 6.4566
786-O GDSC2; CTRP2 7.6037 9.991 5.1691 1.5457
A-498 GDSC2; CTRP2 7.6086 9.2406 5.4857 0.5685
KMRC-2 CTRP2 7.6252 8.8079 5.6572 0.1853
CAL-54 GDSC2; CTRP2 7.6658 9.9622 5.2147 1.3384
TK-10 GDSC2 7.6846 9.771 3.6501 0.2722
KMRC-1 CTRP2 7.9449 9.5995 5.4928 0.3869
UO-31 CTRP2 7.9719 18.2985 1.4401 15.0956
OS-RC-2 GDSC2; CTRP2 8.1412 9.5808 5.577 0.1744
BFTC-909 GDSC2; CTRP2 8.2249 9.6927 5.5687 0.167
SNU-1272 CTRP2 8.3219 9.7176 5.5953 0.1157
769-P GDSC2; CTRP2 8.4068 9.9377 5.5498 0.1538
VMRC-RCW CTRP2 8.4479 9.7945 5.6135 0.0801
KMRC-3 CTRP2 8.5243 10.4207 5.4221 0.3161
VMRC-RCZ GDSC2; CTRP2 8.5963 9.9967 5.5968 0.0768
ACHN GDSC2; CTRP2 8.6173 10.0724 5.5786 0.0897
KMRC-20 GDSC2; CTRP2 8.6631 10.0799 5.5919 0.0734
Caki-1 CTRP2 9.0053 11.1773 5.3348 0.3214
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KM12 GDSC2 5.4827 7.4517 3.5858 2.1762
RKO GDSC2 5.8923 7.5775 3.7423 0.9343
LoVo GDSC2 5.9576 8.32 3.4652 2.1313
SW1116 GDSC2 6.004 7.6345 3.7701 0.7344
SW837 GDSC2 6.039 11.9985 1.8033 11.2278
SNU-175 GDSC2 6.1863 11.9562 1.9246 10.248
SW48 GDSC2 6.1942 15.3933 0.2585 18.3541
SNU-1040 GDSC2 6.2703 7.5457 3.9095 0.1996
SW1463 GDSC2 6.4584 12.473 1.8599 10.033
HCC2998 GDSC2 6.5669 9.9561 3.0826 3.2403
CCK-81 GDSC2 6.6681 9.2589 3.4267 1.516
GP5d GDSC2 6.7257 8.4084 3.7747 0.326
SW626 GDSC2 6.7651 9.2081 3.4912 1.1752
CaR-1 GDSC2 6.7669 8.5001 3.7576 0.349
COLO 320HSR GDSC2 6.8938 8.6753 3.7431 0.3341
RCM-1 [Human ESC] GDSC2; CTRP2 6.9467 8.546 4.5137 0.3674
LS1034 GDSC2; CTRP2 6.9928 8.5997 5.4437 1.1777
GP2d CTRP2 7.1081 15.5872 1.3782 12.2759
CW-2 GDSC2 7.1404 9.1296 3.6745 0.3952
COLO205 GDSC2; CTRP2 7.1734 8.7127 5.4922 0.8491
SNU-C2B GDSC2 7.2345 10.5336 3.177 2.0208
DiFi GDSC2 7.3428 9.517 3.613 0.4582
DLD-1 CTRP2 7.3806 8.2555 5.7615 0.091
HCC-56 CTRP2 7.4497 8.4778 5.7086 0.151
HCT 8 CTRP2 7.5147 8.545 5.7093 0.1329
NCI-H716 GDSC2; CTRP2 7.5768 9.1002 4.5549 0.1267
SNU-C4 CTRP2 7.6349 8.9626 5.6042 0.2796
NCI-H747 GDSC2; CTRP2 7.6876 9.8714 5.2646 1.1597
MDST8 GDSC2; CTRP2 7.7469 9.1262 5.5888 0.2688
OUMS-23 CTRP2 7.7614 8.7341 5.733 0.0604
SNU-503 CTRP2 7.7855 9.4398 5.4862 0.4735
COLO201 CTRP2 7.79 9.1136 5.6105 0.2154
LS411N GDSC2; CTRP2 7.8258 9.1563 5.6089 0.2074
SNU-1033 CTRP2 7.846 13.9743 3.4619 7.7864
SW948 GDSC2; CTRP2 7.8962 9.023 5.682 0.0911
COLO 678 GDSC2; CTRP2 7.9097 13.7165 3.6295 7.0354
HT-55 GDSC2; CTRP2 7.9881 9.3197 5.6122 0.1602
SNU-61 GDSC2; CTRP2 8.001 9.6259 5.506 0.3377
LS123 GDSC2; CTRP2 8.0346 9.5114 5.5614 0.226
HCT 116 GDSC2; CTRP2 8.0903 9.337 5.6434 0.1013
HT-29 GDSC2; CTRP2 8.0997 9.164 5.7052 0.046
HT115 GDSC2; CTRP2 8.1218 9.1645 5.7125 0.0394
SW620 GDSC2; CTRP2 8.2123 10.3206 5.3305 0.6348
SW1417 GDSC2; CTRP2 8.2668 9.7415 5.5671 0.1602
SK-CO-1 GDSC2; CTRP2 8.3952 9.8784 5.5662 0.1361
LS513 GDSC2; CTRP2 8.3973 9.8919 5.5623 0.1403
SNU-81 GDSC2; CTRP2 8.4369 9.8484 5.5914 0.1021
SNU-C5 GDSC2; CTRP2 8.4481 10.068 5.5193 0.185
SNU-407 GDSC2; CTRP2 8.4549 10.0278 5.536 0.1616
T84 GDSC2; CTRP2 8.5043 10.4046 5.4201 0.3258
SNU-C2A CTRP2 8.5228 11.1154 5.1564 0.9078
HCT 15 GDSC2; CTRP2 8.5583 10.2098 5.5103 0.1736
CL-11 GDSC2; CTRP2 8.5776 10.5208 5.4065 0.3267
C2BBe1 GDSC2; CTRP2 8.5962 10.4078 5.4545 0.2432
LS180 GDSC2; CTRP2 8.8607 17.1979 2.6041 9.6136
COLO 320 CTRP2 10.1502 22.9942 0.6989 14.2186
SNU-C1 GDSC2; CTRP2 12.1512 25.3106 0.9 11.1327
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 6.5811 8.4379 3.7075 0.566
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC2 5.6408 10.3806 2.3089 9.2679
HLE GDSC2 6.0247 8.9524 3.2246 3.2844
Hep-G2/C3A GDSC2 6.3187 7.8345 3.8249 0.3729
JHH-1 GDSC2; CTRP2 6.5447 7.9136 5.4867 1.5363
Huh-7 GDSC2 6.6024 8.2212 3.7948 0.3272
JHH-7 GDSC2 6.774 13.8057 1.435 11.6019
JHH-6 GDSC2; CTRP2 6.9107 7.6671 5.7922 0.178
SNU-878 CTRP2 7.4586 9.0898 5.4765 0.6863
Hep 3B2.1-7 GDSC2; CTRP2 7.6528 9.5748 5.3711 0.8601
Hep-G2 CTRP2 7.6854 9.0687 5.5852 0.2986
HuH-1 GDSC2; CTRP2 8.0334 9.6787 5.4995 0.3386
SNU-475 CTRP2 8.0462 9.273 5.6497 0.1018
SK-HEP-1 GDSC2; CTRP2 8.0859 9.741 5.4976 0.3233
HLF CTRP2 8.1468 9.4897 5.611 0.1285
SNU-449 GDSC2; CTRP2 8.2302 9.9284 4.5024 0.0887
JHH-2 GDSC2; CTRP2 8.2491 9.8713 5.5143 0.2422
SNU-387 GDSC2; CTRP2 8.3692 10.2599 5.4195 0.3723
SNU-423 GDSC2; CTRP2 8.384 10.2798 5.4181 0.3697
SNU-761 CTRP2 8.4574 9.8059 5.613 0.0794
JHH-4 GDSC2; CTRP2 8.8442 10.0377 5.6663 0.0208
JHH-5 CTRP2 8.8879 10.4247 5.5536 0.0793
SNU-182 CTRP2 8.9115 11.1 5.3264 0.363
HuH-6 CTRP2 9.0142 10.7007 5.5044 0.1057
Li-7 CTRP2 9.8745 24.414 -0.1773 17.1339
PLC/PRF/5 CTRP2 10.9472 18.7005 3.1841 5.1479
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 188 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1048 GDSC2 4.8957 6.4687 3.6808 2.6629
COR-L23 GDSC2 5.1543 7.3498 3.4328 3.6192
NCI-H2803 GDSC2 5.1813 7.0524 3.5891 2.6562
NCI-H2818 GDSC2 5.2087 7.1211 3.5742 2.692
NCI-H2461 GDSC2 5.4836 7.5977 3.5209 2.5259
NCI-H2810 GDSC2 5.615 9.5715 2.6809 7.1428
NCI-H596 GDSC2 5.6265 8.0817 3.3858 3.0372
NCI-H345 GDSC2 5.6341 6.9019 3.893 0.5671
NCI-H513 GDSC2 5.6577 7.9896 3.4453 2.6627
LK-2 GDSC2 5.7229 16.4296 -0.6076 22.839
LOU-NH91 GDSC2; CTRP2 5.7446 7.2641 4.4496 1.5297
SBC-3 GDSC2 5.7474 7.9857 3.4973 2.2545
NCI-H1963 GDSC2 5.7652 8.5627 3.2494 3.5636
NCI-H3255 GDSC2 5.7685 7.7152 3.6252 1.5868
NCI-H2369 GDSC2 5.8843 7.8168 3.6408 1.3803
NCI-H2869 GDSC2 5.955 8.066 3.572 1.618
NCI-H1781 GDSC2 5.9703 7.6388 3.7534 0.8234
COLO 668 GDSC2 5.998 8.2819 3.5027 1.8963
NCI-H720 GDSC2 6.0503 7.385 3.8835 0.3444
NCI-H1975 GDSC2; CTRP2 6.1273 8.0302 5.1197 3.7297
NCI-H82 GDSC2 6.2751 7.7074 3.854 0.319
Lu-165 GDSC2 6.2912 7.5435 3.9179 0.1778
EPLC-272H GDSC2 6.3017 8.999 3.3544 2.2387
NCI-H524 GDSC2 6.3222 7.917 3.7961 0.4487
NCI-H250 GDSC2 6.3957 9.5993 3.1453 3.1574
Lu-135 GDSC2 6.4078 8.0945 3.7649 0.4927
NCI-H2029 GDSC2 6.4112 8.0527 3.7817 0.444
NCI-H2141 GDSC2; CTRP2 6.5023 7.923 5.4539 1.725
NCI-H1876 GDSC2 6.5208 8.2392 3.7567 0.4582
LC-1/sq-SF CTRP2 6.5228 8.0161 4.5358 0.5219
NCI-H1155 GDSC2; CTRP2 6.5973 8.3454 5.3157 2.1458
RERF-LC-KJ GDSC2 6.601 8.4029 3.7284 0.4958
EMC-BAC-2 GDSC2 6.6022 8.785 3.5845 0.9567
VMRC-LCD GDSC2; CTRP2 6.6131 8.6813 4.307 1.1625
NCI-H209 GDSC2 6.6235 8.7693 3.5998 0.887
NCI-H2227 GDSC2 6.6626 8.5647 3.6934 0.563
NCI-H661 GDSC2; CTRP2 6.7022 9.2089 4.1274 1.7112
HCC1195 CTRP2 6.7415 8.0995 4.5965 0.2745
IA-LM GDSC2; CTRP2 6.7565 8.222 4.5569 0.3522
Lu-139 GDSC2 6.7675 8.3574 3.8081 0.2432
NCI-H2135 GDSC2 6.7879 8.2302 3.8593 0.1521
UMC-11 GDSC2 6.7972 8.627 3.7236 0.4172
NCI-H810 GDSC2; CTRP2 6.8029 8.3418 5.4494 1.3606
COR-L95 CTRP2 6.8109 8.4108 5.4226 1.4522
NCI-H647 CTRP2 6.846 9.0626 5.1397 2.5053
NCI-H2722 GDSC2 6.8858 8.6935 3.7336 0.358
NCI-H889 CTRP2 6.8862 8.5763 4.4769 0.4792
NCI-H2373 GDSC2 6.8962 8.4023 3.8388 0.159
NCI-H2595 GDSC2 6.9078 8.6018 3.7742 0.2657
RERF-LC-Ad2 CTRP2 6.9121 8.5509 4.4975 0.4183
NCI-H3122 GDSC2 6.9133 9.1007 3.5957 0.7136
CPC-N GDSC2 6.9386 9.1403 3.5912 0.7126
NCI-H2795 GDSC2 6.9544 8.9525 3.6668 0.4913
NCI-H2804 GDSC2 6.9642 9.2381 3.5651 0.7783
ABC-1 GDSC2 6.9694 8.8705 3.7022 0.3979
NCI-H1581 GDSC2; CTRP2 7.0227 9.3021 5.1407 2.2732
NCI-H2731 GDSC2 7.0295 9.1072 3.6399 0.5267
RERF-LC-Ad1 CTRP2 7.0666 7.9112 5.7647 0.1732
HCC827 GDSC2; CTRP2 7.0768 8.9157 5.3505 1.4251
Ms-1 GDSC2 7.1019 8.5953 3.8451 0.1132
NCI-H1755 GDSC2; CTRP2 7.1323 9.6676 5.0393 2.5288
LC-1/sq GDSC2 7.1335 9.1171 3.6764 0.3936
SW1573 GDSC2; CTRP2 7.1458 9.976 4.0314 1.6427
NCI-H2444 CTRP2 7.1528 8.7577 5.4621 0.9647
NCI-H446 GDSC2; CTRP2 7.1577 8.8695 4.4789 0.3574
HCC2935 CTRP2 7.17 16.7034 1.6214 15.8362
Lu-99A GDSC2 7.1879 9.2951 3.6333 0.4729
A-427 GDSC2 7.2068 9.3043 3.6373 0.4555
NCI-H2110 CTRP2 7.2686 9.3956 5.2456 1.6037
NCI-H2085 GDSC2; CTRP2 7.2691 9.2513 4.3816 0.5249
NCI-H1993 GDSC2 7.2873 8.9129 3.8024 0.1337
IST-SL2 GDSC2 7.2896 9.5078 3.5958 0.522
NCI-H2009 CTRP2 7.2938 9.2183 5.338 1.256
SBC-5 GDSC2; CTRP2 7.2965 8.1147 5.7799 0.0845
NCI-H2591 GDSC2 7.3425 9.3817 3.6609 0.3527
NCI-H1623 GDSC2; CTRP2 7.3835 9.4048 4.3713 0.4972
HCC2108 CTRP2 7.3886 9.4655 5.2816 1.3608
RERF-LC-Sq1 GDSC2 7.406 10.0418 3.4454 0.8867
COR-L311 GDSC2 7.4132 9.0772 3.7906 0.1272
HCC1833 CTRP2 7.4384 10.243 4.9617 2.4601
NCI-H1385 CTRP2 7.4979 9.7748 5.2059 1.5182
NCI-H322M GDSC2 7.5023 9.3778 3.72 0.2039
HCC44 GDSC2; CTRP2 7.5105 9.7899 5.2062 1.5055
DMS 79 GDSC2; CTRP2 7.5144 10.2064 5.0233 2.1493
NCI-H1395 CTRP2 7.5401 10.673 4.826 2.8527
DMS 53 GDSC2; CTRP2 7.553 9.5846 5.3172 1.1005
MOR/CPR CTRP2 7.6058 8.4548 5.7732 0.0448
NCI-H1694 GDSC2; CTRP2 7.6972 9.0232 5.6069 0.2518
SK-MES-1 GDSC2; CTRP2 7.7229 9.6433 5.3768 0.7963
LCLC-103H GDSC2; CTRP2 7.7254 8.9881 5.6308 0.2001
NCI-H1435 GDSC2; CTRP2 7.7299 9.3006 5.5158 0.4307
Calu-1 CTRP2 7.7513 10.3199 5.1057 1.6261
DMS 114 GDSC2; CTRP2 7.754 9.4614 5.4639 0.544
NCI-H1563 GDSC2; CTRP2 7.7659 10.028 5.2384 1.1806
DMS 454 CTRP2 7.7661 10.3956 5.0807 1.6973
NCI-H196 GDSC2; CTRP2 7.7663 9.1713 5.5799 0.2791
NCI-H322 CTRP2 7.7977 9.9414 5.2904 0.9971
NCI-H2126 CTRP2 7.8226 8.8866 5.7026 0.081
Lu-65 GDSC2; CTRP2 7.8294 9.9746 5.2922 0.9693
ChaGo-K-1 CTRP2 7.8363 10.108 5.2402 1.121
Lu-99 CTRP2 7.8676 9.3205 5.5654 0.2711
NCI-H1105 CTRP2 7.8739 11.1094 4.8252 2.488
HCC95 CTRP2 7.8896 9.2876 5.5861 0.227
NCI-H1650 GDSC2; CTRP2 7.93 9.7595 4.4543 0.1829
HCC4006 CTRP2 7.9365 9.5544 5.5063 0.3619
NCI-H69 CTRP2 7.9401 9.8519 5.3934 0.6216
NCI-H460 CTRP2 7.9447 9.7707 5.4272 0.5358
NCI-H1651 GDSC2; CTRP2 7.9468 10.8603 4.9761 1.8873
DMS 273 GDSC2; CTRP2 7.9547 10.1128 5.2958 0.8746
NCI-H1092 GDSC2; CTRP2 7.9756 9.1836 5.6552 0.1076
HOP-92 GDSC2; CTRP2 8.0133 10.2091 5.2843 0.8691
NCI-H526 GDSC2; CTRP2 8.0217 9.3475 5.6149 0.149
HOP-62 GDSC2; CTRP2 8.024 9.7184 5.4808 0.38
NCI-H226 GDSC2; CTRP2 8.0672 9.204 5.6806 0.0684
CAL-12T CTRP2 8.0712 9.7506 5.4881 0.347
NCI-H2081 CTRP2 8.0809 9.9234 5.427 0.4719
COR-L88 CTRP2 8.0873 10.4881 5.2059 1.0437
NCI-H1341 CTRP2 8.1026 9.7428 5.5036 0.3061
LCLC-97TM1 GDSC2; CTRP2 8.1069 10.529 5.1986 1.0516
RERF-LC-MS CTRP2 8.117 9.5557 5.5769 0.1803
NCI-H1838 CTRP2 8.1345 9.8313 5.4838 0.3325
NCI-H1339 CTRP2 8.1401 9.444 5.6244 0.1141
KNS-62 GDSC2; CTRP2 8.1496 9.3178 5.6708 0.0669
NCI-H1568 GDSC2; CTRP2 8.1575 9.9028 5.4665 0.3577
NCI-H650 GDSC2; CTRP2 8.1662 9.7442 5.5281 0.243
NCI-H2106 CTRP2 8.1688 9.7231 5.5367 0.2282
Calu-6 GDSC2; CTRP2 8.175 11.3187 4.8998 1.9387
NCI-H841 GDSC2; CTRP2 8.1785 9.7242 5.54 0.2203
NCI-H838 CTRP2 8.1896 9.5716 5.5981 0.1361
HARA [Human squamous cell lung carcinoma] GDSC2; CTRP2 8.2095 12.4531 4.4141 3.6283
NCI-H1915 GDSC2; CTRP2 8.2199 9.6954 5.5659 0.1719
NCI-H2172 CTRP2 8.2252 9.698 5.567 0.1693
NCI-H358 GDSC2; CTRP2 8.2272 9.8467 5.5147 0.2477
Calu-3 GDSC2; CTRP2 8.2381 9.7564 5.5511 0.1885
HCC366 GDSC2; CTRP2 8.256 9.7848 5.5478 0.1891
NCI-H2196 CTRP2 8.2837 9.6542 5.6035 0.1131
NCI-H1703 CTRP2 8.2855 9.805 5.5516 0.1769
NCI-H2030 CTRP2 8.2997 9.7052 5.5916 0.1236
HCC78 GDSC2; CTRP2 8.3308 10.1795 5.4339 0.3584
Sq-1 CTRP2 8.3404 9.4833 5.6807 0.0417
NCI-H2405 GDSC2; CTRP2 8.341 10.5252 5.3072 0.6266
NCI-H2087 GDSC2; CTRP2 8.3684 10.1595 5.4561 0.3051
NCI-H1693 GDSC2; CTRP2 8.3742 10.2324 5.4317 0.3474
SHP-77 GDSC2; CTRP2 8.38 9.6051 5.6537 0.0559
LUDLU-1 CTRP2 8.388 10.064 5.4982 0.23
NCI-H1666 GDSC2; CTRP2 8.3889 10.2391 5.4351 0.3363
NCI-H441 GDSC2 8.4155 19.7929 -0.3257 16.1048
HCC1588 CTRP2 8.4204 9.8935 5.5701 0.1273
NCI-H1373 CTRP2 8.4259 10.1811 5.4707 0.2633
T3M-10 CTRP2 8.4384 10.0064 5.5374 0.1632
NCI-H23 GDSC2; CTRP2 8.4418 10.2338 5.4578 0.2801
NCI-H1734 CTRP2 8.4722 10.2873 5.4502 0.2838
PC-14 GDSC2; CTRP2 8.4844 10.1904 5.4896 0.2187
NCI-H727 GDSC2; CTRP2 8.4912 10.3116 5.4488 0.2807
NCI-H1573 CTRP2 8.5042 10.0662 5.5406 0.1465
NCI-H2228 GDSC2; CTRP2 8.5085 10.7074 5.309 0.5454
COLO 699 CTRP2 8.5362 10.066 5.5522 0.1276
NCI-H1944 GDSC2; CTRP2 8.5439 10.8697 5.2619 0.6354
LXF 289 GDSC2; CTRP2 8.5475 10.1619 5.523 0.1597
HCC1171 CTRP2 8.5586 10.1273 5.5391 0.1385
NCI-H2342 CTRP2 8.5597 10.8144 5.2898 0.5651
NCI-H2291 CTRP2 8.5978 10.1179 5.5563 0.1136
SK-LU-1 GDSC2; CTRP2 8.6137 10.3157 5.4936 0.1838
NCI-H2170 GDSC2; CTRP2 8.6483 9.9385 5.6339 0.0461
COR-L105 GDSC2; CTRP2 8.6639 12.9084 4.4713 2.9492
NCI-H2023 GDSC2; CTRP2 8.6827 10.2238 5.5501 0.1074
RERF-LC-A1 CTRP2 8.722 10.1011 5.6049 0.0583
NCI-H522 GDSC2; CTRP2 8.7683 10.7031 5.4143 0.2601
NCI-H211 GDSC2; CTRP2 8.7717 10.6272 5.4425 0.2183
NCI-H1299 GDSC2; CTRP2 8.7771 10.2945 5.5591 0.0871
NCI-H1792 GDSC2; CTRP2 8.7889 10.3267 5.5524 0.0915
HCC15 GDSC2; CTRP2 8.8131 14.8864 3.6625 5.7307
EBC-1 GDSC2; CTRP2 8.9589 10.7448 5.4698 0.1481
NCI-H520 GDSC2; CTRP2 8.9717 10.8221 5.4477 0.1709
HCC1438 CTRP2 8.9818 16.2532 3.1312 7.5038
SW1271 GDSC2; CTRP2 9.0239 10.5752 5.5498 0.0686
NCI-H1184 CTRP2 9.0569 10.8337 5.4742 0.1283
NCI-H1355 GDSC2; CTRP2 9.0647 10.7777 5.496 0.1068
NCI-H1869 GDSC2; CTRP2 9.1072 10.9896 5.4386 0.1577
EKVX GDSC2; CTRP2 9.234 18.3934 2.283 10.2595
HCC2279 CTRP2 9.6445 11.1846 5.5565 0.0274
A-549 GDSC2; CTRP2 10.4658 19.8811 2.3716 8.3967
NCI-H1793 GDSC2; CTRP2 11.3102 22.4005 1.7269 9.5486
BEN CTRP2 11.4047 28.4332 -1.0592 17.3616
NCI-H292 CTRP2 12.6336 25.2035 1.2397 9.6038
LK2 CTRP2 13.3351 28.3148 0.2391 11.7094
NCI-H2122 GDSC2; CTRP2 13.4058 27.1493 0.8122 10.0468
Hs 888.Lu CTRP2 8.1585 10.2294 5.3424 0.6334
⏷ Show the Full List of 188 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 6.5792 8.4653 3.6965 0.5997
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 6.1733 7.143 4.7217 0.2349
SYO-1 CTRP2 7.3561 24.3272 -2.0281 25.6126
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 6.8366 8.3828 4.5296 0.3788
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 7.8927 15.0527 2.9722 9.6299
Yamato-SS CTRP2 11.0988 25.2026 0.2794 14.1999
SW684 GDSC2 5.8802 7.201 3.8832 0.4354
MES-SA GDSC2 5.9391 7.6105 3.7506 0.8605
SW982 GDSC2; CTRP2 6.0713 11.2868 3.4456 10.8439
Rh41 GDSC2; CTRP2 6.1556 9.0702 4.6232 5.7626
SW872 GDSC2 6.278 8.4064 3.5882 1.2116
VA-ES-BJ GDSC2 6.3241 7.8833 3.8092 0.4118
EW-8 GDSC2 6.5663 8.119 3.8175 0.29
BT-12 CTRP2 6.7768 7.7826 5.6831 0.5607
Rh30 GDSC2 7.0779 8.7882 3.7712 0.2233
Tm87-16 CTRP2 7.1602 10.8105 4.5149 4.5669
TE 441.T CTRP2 7.3598 11.1888 4.4686 4.4726
KYM-1 GDSC2; CTRP2 7.3676 9.0351 5.4547 0.8149
A-204 GDSC2; CTRP2 7.3823 9.9984 5.0397 2.2329
BT-16 CTRP2 7.6731 8.8224 5.6704 0.1514
HT-1080 GDSC2; CTRP2 7.7091 9.281 5.5144 0.4439
SK-LMS-1 GDSC2; CTRP2 7.7506 9.6361 5.3928 0.7335
TE 617.T CTRP2 7.8967 9.2323 5.6088 0.1879
RKN GDSC2; CTRP2 7.9078 9.023 5.6862 0.085
G-402 GDSC2; CTRP2 8.1467 10.6575 5.165 1.1225
Hs 729.T CTRP2 8.5585 10.2826 5.4847 0.208
G-401 GDSC2; CTRP2 8.6092 11.2869 5.1276 0.9339
SK-UT-1 GDSC2; CTRP2 8.6372 10.9478 5.2717 0.5713
RD GDSC2; CTRP2 8.6949 11.0739 5.248 0.5983
GCT GDSC2; CTRP2 8.8045 16.4158 2.9392 8.4511
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 8.2824 10.6344 5.2382 0.8311
TOV-21G GDSC2; CTRP2 5.8476 6.532 5.622 2.1956
JHOS-2 CTRP2 6.0768 7.6736 5.2567 3.249
ES-2 GDSC2 6.1966 7.6282 3.8522 0.358
OVCAR-4 GDSC2 6.6622 9.0657 3.5011 1.2216
TOV-112D GDSC2; CTRP2 6.7128 8.6534 5.2461 2.2635
JHOM-1 CTRP2 6.7759 8.2057 4.571 0.3138
OVCAR-3 GDSC2 6.9004 8.3902 3.8444 0.1501
EFO-21 GDSC2; CTRP2 7.0022 8.6477 4.4984 0.3777
FU-OV-1 CTRP2 7.0549 8.898 4.4256 0.5215
IGROV-1 GDSC2; CTRP2 7.2286 24.2894 -2.111 26.0044
OVISE GDSC2; CTRP2 7.523 8.5795 5.7001 0.1446
ES2 CTRP2 7.5471 8.7877 5.6336 0.254
OVSAHO CTRP2 7.5907 9.2592 5.4701 0.6205
ONCO-DG-1 CTRP2 7.618 14.419 3.0851 9.614
TYK-nu GDSC2; CTRP2 7.6983 9.3453 5.4847 0.5216
COV434 CTRP2 7.8197 9.9298 5.306 0.9355
OAW42 GDSC2; CTRP2 7.8565 8.9355 5.6979 0.0807
OVK18 GDSC2; CTRP2 7.8569 9.2203 5.5978 0.217
SNU-8 CTRP2 7.9214 8.8351 5.7539 0.0302
DOV13 GDSC2; CTRP2 7.9307 9.7716 5.4207 0.5586
OVCAR-5 GDSC2; CTRP2 7.9328 10.4905 5.1279 1.3976
OV56 GDSC2; CTRP2 7.937 8.9914 5.7071 0.0614
A2780 GDSC2; CTRP2 7.975 9.7636 5.443 0.4839
HEY A8 CTRP2 8.0864 9.4977 5.586 0.1745
OC 314 CTRP2 8.1422 9.3713 5.6501 0.0866
Caov-3 CTRP2 8.2065 9.5048 5.6273 0.1001
JHOC-5 CTRP2 8.3013 9.5567 5.6429 0.0726
EFO-27 GDSC2; CTRP2 8.3244 10.0743 5.4699 0.2947
COV362 CTRP2 8.3725 10.16 5.4576 0.3014
RMG-I CTRP2 8.4221 10.5914 5.3166 0.5666
SK-OV-3 GDSC2; CTRP2 8.5386 10.3457 5.4547 0.2578
OV-90 GDSC2; CTRP2 8.582 13.4174 4.1965 4.0171
Kuramochi GDSC2; CTRP2 8.6814 10.4821 5.4601 0.2144
SNU-840 CTRP2 8.691 10.4546 5.4733 0.1942
OVCAR-8 GDSC2; CTRP2 8.7282 14.5931 3.7458 5.5211
SNU-119 CTRP2 8.7485 10.4775 5.4864 0.166
OVTOKO GDSC2; CTRP2 8.8131 10.4519 5.5183 0.1199
OAW28 GDSC2; CTRP2 9.0753 10.9569 5.4385 0.1633
COV644 CTRP2 9.6703 18.6779 2.4334 9.1525
OV7 CTRP2 9.874 20.2222 1.8367 10.9473
MCAS CTRP2 10.0325 32.5434 -4.046 25.3833
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2; CTRP2 6.3783 9.106 3.9882 2.603
MPP 89 GDSC2; CTRP2 7.7191 9.2591 5.5272 0.4096
NCI-H2052 GDSC2; CTRP2 7.9383 9.701 4.4775 0.1532
IST-Mes1 GDSC2; CTRP2 8.1139 10.1182 5.3661 0.5983
NCI-H2452 CTRP2 8.1594 10.2622 5.3299 0.6636
ACC-MESO-1 CTRP2 8.1679 9.3892 5.653 0.0803
NCI-H28 GDSC2; CTRP2 8.8666 10.4887 5.5247 0.1064
JL-1 CTRP2 13.9365 52.661 -11.8214 29.0898
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PC-3 GDSC2 6.5993 8.9232 3.5291 1.1657
LNCaP clone FGC GDSC2; CTRP2 7.0679 9.1831 5.2238 1.9026
VCaP GDSC2; CTRP2 7.2721 9.1481 5.3568 1.2118
PaCa-3 CTRP2 7.9637 9.1141 5.6748 0.0881
DU145 GDSC2; CTRP2 8.6685 10.4584 5.4636 0.2124
22Rv1 GDSC2; CTRP2 8.7364 10.7671 5.379 0.3258
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 7.7102 8.7388 5.7133 0.0876
A-253 GDSC2; CTRP2 8.1188 9.8909 5.4551 0.3955
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 6.8502 8.4925 3.7913 0.2505
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-GT-2 GDSC2 5.4002 10.1411 2.2547 10.1382
NCI-N87 GDSC2 5.7187 9.2386 2.9074 5.6029
GCIY GDSC2 5.9516 8.0822 3.5635 1.6619
RF-48 GDSC2 6.5115 8.4933 3.6578 0.7654
SNU-5 GDSC2 6.6003 8.2774 3.7738 0.3777
OCUM-1 GDSC2 6.7034 9.0714 3.5173 1.126
SH-10-TC CTRP2 6.7056 17.5889 0.097 17.6087
RERF-GC-1B GDSC2 6.842 9.3927 3.4529 1.2582
MKN45 GDSC2; CTRP2 6.8855 12.944 3.268 10.0856
GSU CTRP2 7.0512 7.7188 5.8283 0.0724
HuG1-N CTRP2 7.1305 11.1725 4.3194 5.4014
NUGC-4 GDSC2; CTRP2 7.4726 10.3717 4.9233 2.5647
ECC10 GDSC2; CTRP2 7.7238 9.1385 4.5931 0.0711
MKN7 CTRP2 7.7244 9.7353 4.3858 0.3404
IM95 GDSC2; CTRP2 7.7444 9.6467 5.3856 0.7575
KATO III GDSC2; CTRP2 7.7482 9.6358 5.3918 0.7379
MKN28 GDSC2 7.8365 9.8432 3.6792 0.1933
Hs 746.T GDSC2; CTRP2 7.856 9.3667 5.5436 0.3173
ECC12 CTRP2 7.8903 8.8552 5.7367 0.0434
SNU-668 CTRP2 7.9191 8.9722 5.7074 0.0633
SNU-1 GDSC2; CTRP2 7.9401 9.805 5.4118 0.5755
23132/87 GDSC2; CTRP2 7.9706 9.3831 5.5829 0.2088
MKN1 GDSC2; CTRP2 8.1243 9.7375 5.5142 0.2797
SNU-601 CTRP2 8.1376 9.451 5.6211 0.1183
LMSU CTRP2 8.2285 10 5.4591 0.3464
GSS CTRP2 8.257 9.4777 5.6542 0.0683
SNU-216 CTRP2 8.3194 10.0951 5.4604 0.3132
AGS GDSC2; CTRP2 8.4486 9.8991 5.5782 0.1138
HGC-27 GDSC2; CTRP2 8.5018 10.0353 5.5504 0.1355
NUGC-3 GDSC2; CTRP2 8.5089 9.9812 5.5715 0.1114
MKN74 CTRP2 8.675 10.4934 5.4537 0.2249
SNU-719 CTRP2 8.6814 10.2733 5.5328 0.1251
KE-39 CTRP2 9.8875 12.1753 5.3098 0.1709
SNU-16 CTRP2 12.3676 27.9155 -0.1776 13.9127
SNU-685 CTRP2 6.767 11.7523 2.9946 6.2019
SNG-M GDSC2 7.0129 8.9446 3.6922 0.4039
SNU-1077 CTRP2 8.2788 9.6938 5.5881 0.1315
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC2 6.0611 7.4374 3.8685 0.3796
CAL-62 GDSC2; CTRP2 6.1074 7.1083 5.564 1.9008
K5 GDSC2 6.1533 7.8482 3.7521 0.6891
HTC-C3 GDSC2 6.1896 8.6277 3.4542 1.8973
ASH-3 GDSC2 6.7979 8.3093 3.8358 0.1862
WRO GDSC2 6.887 8.7288 3.7215 0.3854
TT CTRP2 7.761 9.1962 5.5684 0.3035
SW579 CTRP2 7.8334 8.8251 5.7273 0.0566
TT2609-C02 GDSC2; CTRP2 7.9041 9.8135 5.3924 0.6438
ML-1 [Human leukemia] CTRP2 8.0025 9.9305 5.3903 0.5962
8305C GDSC2; CTRP2 8.0945 9.5547 5.5687 0.198
BHT-101 GDSC2; CTRP2 8.1418 9.9787 5.4316 0.4356
CGTH-W-1 CTRP2 8.2741 9.6058 5.6167 0.1007
FTC-238 CTRP2 8.3068 9.806 5.5592 0.1621
FTC-133 GDSC2; CTRP2 8.3285 9.7415 5.5895 0.1211
B-CPAP GDSC2; CTRP2 8.4876 9.6682 5.6691 0.0377
8505C GDSC2; CTRP2 8.8305 10.6039 5.4723 0.1677
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3118 GDSC2 5.485 8.6597 3.0289 5.3519
SCC-15 GDSC2 5.8544 8.1868 3.4677 2.2575
DOK GDSC2 5.9493 9.0938 3.1171 3.9908
SAT [Human HNSCC] GDSC2 6.4944 11.4291 2.3745 7.1592
BICR 10 GDSC2 6.5053 19.0258 -1.2992 23.3146
OSC-20 GDSC2 6.5229 8.8139 3.5379 1.1964
HO-1-N-1 GDSC2 6.5233 8.1127 3.8035 0.3381
BB49-HNC GDSC2 6.6069 9.1046 3.4603 1.4341
SAS GDSC2 6.6564 9.7998 3.1968 2.5618
BICR 78 GDSC2 6.7116 9.3942 3.3923 1.6182
UPCI-SCC-090 GDSC2 6.7927 9.0206 3.5757 0.8529
JHU-022 GDSC2 6.8242 9.1796 3.5282 0.9947
HSC-4 GDSC2; CTRP2 7.0221 9.1975 5.189 2.0885
SCC-4 GDSC2 7.0695 8.6435 3.8177 0.1535
LB771-HNC GDSC2 7.0894 10.367 3.1757 2.1724
Ca9-22 GDSC2 7.2238 9.0075 3.7479 0.2252
PCI-04B GDSC2 7.2989 9.3121 3.6692 0.3501
PE/CA-PJ34 (clone C12) CTRP2 7.4331 9.1049 5.458 0.7576
SNU-1076 CTRP2 7.4549 11.0153 4.6132 3.7756
SKN-3 GDSC2 7.551 9.3936 3.7318 0.1771
HSC-3 GDSC2; CTRP2 7.6688 8.8753 5.6497 0.1851
PE/CA-PJ49 CTRP2 7.6985 8.869 5.6633 0.1556
HSC-2 GDSC2; CTRP2 7.7077 9.389 5.4717 0.5492
BICR 18 CTRP2 7.7328 9.7827 5.3243 0.9423
YD-10B CTRP2 7.8722 9.1902 5.6146 0.1854
CAL-27 GDSC2; CTRP2 7.9127 9.4105 5.5503 0.2839
BHY CTRP2 7.9162 9.621 5.4726 0.4435
BICR 22 GDSC2; CTRP2 7.9502 9.2154 5.6348 0.1376
BICR 31 CTRP2 7.995 9.9271 5.3883 0.6051
BICR 56 CTRP2 8.0718 10.1914 5.3185 0.7412
SNU-899 CTRP2 8.1706 9.3629 5.6629 0.0712
FaDu GDSC2; CTRP2 8.196 9.5909 5.5937 0.1403
Detroit 562 GDSC2; CTRP2 8.2366 10.066 5.4379 0.3849
SNU-1066 CTRP2 8.3626 9.8307 5.5709 0.1365
PE/CA-PJ41 (clone D2) CTRP2 8.4371 9.7623 5.6207 0.0753
CAL-33 GDSC2; CTRP2 8.4485 10.072 5.5181 0.1866
SNU-46 CTRP2 8.4616 10.0857 5.5181 0.1837
SNU-1214 CTRP2 8.4711 10.3905 5.4121 0.351
BICR 16 CTRP2 8.4786 10.2534 5.4649 0.2581
PE/CA-PJ15 CTRP2 8.542 10.1453 5.5268 0.156
SNU-1041 CTRP2 8.6974 10.3905 5.4981 0.1616
SCC-9 GDSC2; CTRP2 9.2281 17.3599 2.7689 8.5191
BICR 6 CTRP2 13.6807 41.8351 -6.746 23.2507
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW780 GDSC2 5.597 7.3291 3.701 1.4316
RT-112 GDSC2 6.2939 14.798 0.6225 16.536
647V GDSC2; CTRP2 6.4104 8.0011 5.3518 2.2764
SCaBER CTRP2 6.5035 8.974 4.9424 3.818
SW1710 GDSC2 6.8474 9.1504 3.5493 0.9052
CAL-29 GDSC2; CTRP2 6.974 8.4549 5.4973 1.0084
5637 GDSC2; CTRP2 7.4167 11.3982 4.4066 4.6409
KU-19-19 GDSC2; CTRP2 7.5126 9.6769 5.2565 1.3331
253J CTRP2 7.5616 8.9257 5.5877 0.3443
639V GDSC2; CTRP2 7.6711 8.7722 5.6874 0.1275
BFTC-905 GDSC2; CTRP2 7.7024 9.381 5.4725 0.5501
BC-3C CTRP2 7.9378 9.4932 5.5297 0.3144
UM-UC-3 CTRP2 8.0607 9.5779 5.5474 0.2416
U-BLC1 CTRP2 8.1515 13.6861 3.8046 6.0211
J82 GDSC2; CTRP2 8.2641 10.0028 5.4723 0.3096
JMSU-1 CTRP2 8.2947 9.8134 5.5521 0.1742
RT-4 GDSC2; CTRP2 8.3278 9.7293 5.5934 0.1168
TCCSUP GDSC2; CTRP2 8.3399 9.8106 5.5697 0.1422
HT-1376 CTRP2 8.4496 10.1905 5.4764 0.2477
KMBC-2 CTRP2 8.4794 10.3983 5.4126 0.3474
HT-1197 GDSC2; CTRP2 8.6078 10.0429 5.5853 0.0851
T24 CTRP2 9.0249 10.9752 5.4138 0.2023
VM-CUB-1 CTRP2 9.1544 10.6953 5.5542 0.0551
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC2 5.1196 9.9117 2.1608 11.3753
DSH1 GDSC2 5.4701 7.9923 3.3324 3.6074
LB831-BLC GDSC2 5.4882 9.0232 2.8579 6.3609
SiHa GDSC2 5.6221 9.9843 2.4874 8.2671
OVMIU GDSC2 5.677 10.6123 2.222 9.6894
OVCA420 GDSC2 5.7211 7.4126 3.7282 1.1628
HT-3 GDSC2 5.9125 7.7655 3.6757 1.1951
SW756 GDSC2 5.9638 7.7906 3.6898 1.0844
PA-1 GDSC2 6.2075 7.8304 3.7818 0.5557
C-33 A GDSC2 6.2798 8.3988 3.5921 1.1941
HEC-1 GDSC2 6.3024 10.5197 2.6768 5.8327
PEO1 GDSC2 6.4179 9.2389 3.3123 2.299
C-4-I GDSC2 6.4517 7.9967 3.8177 0.3333
HEY GDSC2 6.4832 9.4744 3.2458 2.539
SKG-IIIa GDSC2 6.5092 8.1194 3.7957 0.3627
DoTc2 4510 GDSC2 6.5207 8.2061 3.7687 0.4259
NEC8 GDSC2 6.566 8.1542 3.8049 0.3181
MS751 GDSC2 6.6353 8.4787 3.7142 0.518
PWR-1E GDSC2 6.753 8.77 3.6537 0.6299
SKN GDSC2 6.9148 8.9817 3.6405 0.5814
TC-YIK GDSC2 7.129 8.9184 3.7446 0.2562
CAL-39 GDSC2 7.1562 9.1179 3.6846 0.367
SiSo GDSC2 7.3935 9.7224 3.5584 0.5709
ME-180 GDSC2 7.4259 10.4193 3.3095 1.3325
Ca Ski GDSC2 7.6895 10.2103 3.4966 0.5957
HeLa GDSC2; CTRP2 13.124 26.7213 0.8403 10.2554
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Nelarabine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Roflumilast DMPGHY8 Moderate Additive immunosuppressive effects by the combination of Nelarabine and Roflumilast. Asthma [CA23] [8]
Brentuximab vedotin DMWLC57 Moderate Increased risk of peripheral neuropathy by the combination of Nelarabine and Brentuximab vedotin. Hodgkin lymphoma [2B30] [9]
Teriflunomide DMQ2FKJ Major Additive myelosuppressive effects by the combination of Nelarabine and Teriflunomide. Hyper-lipoproteinaemia [5C80] [10]
Polyethylene glycol DM4I1JP Moderate Increased risk of lowers seizure threshold by the combination of Nelarabine and Polyethylene glycol. Irritable bowel syndrome [DD91] [11]
Denosumab DMNI0KO Moderate Additive myelosuppressive effects by the combination of Nelarabine and Denosumab. Low bone mass disorder [FB83] [12]
Tecfidera DM2OVDT Moderate Additive immunosuppressive effects by the combination of Nelarabine and Tecfidera. Multiple sclerosis [8A40] [13]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Nelarabine and Siponimod. Multiple sclerosis [8A40] [14]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Nelarabine and Fingolimod. Multiple sclerosis [8A40] [15]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Nelarabine and Ocrelizumab. Multiple sclerosis [8A40] [16]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Nelarabine and Ozanimod. Multiple sclerosis [8A40] [8]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive myelosuppressive effects by the combination of Nelarabine and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [17]
Canakinumab DM8HLO5 Moderate Additive immunosuppressive effects by the combination of Nelarabine and Canakinumab. Rheumatoid arthritis [FA20] [18]
Rilonacept DMGLUQS Moderate Additive immunosuppressive effects by the combination of Nelarabine and Rilonacept. Rheumatoid arthritis [FA20] [18]
Golimumab DMHZV7X Major Additive immunosuppressive effects by the combination of Nelarabine and Golimumab. Rheumatoid arthritis [FA20] [19]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Nelarabine when combined with Anthrax vaccine. Sepsis [1G40-1G41] [20]
Valganciclovir DMS2IUH Moderate Additive myelosuppressive effects by the combination of Nelarabine and Valganciclovir. Virus infection [1A24-1D9Z] [14]
⏷ Show the Full List of 16 DDI Information of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7090).
2 Nelarabine FDA Label
3 BDDCS applied to over 900 drugs
4 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
5 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
6 Nelarabine. Drugs. 2008;68(4):439-47.
7 Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. Onco Targets Ther. 2009 Feb 18;2:219-28.
8 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
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10 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
11 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
12 Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
13 Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
14 Cerner Multum, Inc. "Australian Product Information.".
15 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
16 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
17 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
18 Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
19 Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
20 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]