Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTV7Y40)

• DTT Name: Mycobacterium Orotidine phosphate decarboxylase (MycB pyrF)
• Synonyms: Orotidine 5'-phosphate decarboxylase; OMPdecase; OMPDCase; OMP decarboxylase
• Gene Name: MycB pyrF
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Carbon-carbon lyase
• UniProt ID: PYRF_MYCTO
• TTD ID: T81015
• EC Number: EC 4.1.1.23
• Sequence:
  MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKP
  QVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADA
  VTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNAAADGRSVAQLVVDQVGA
  ANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLL
  PAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV
• Function: Catalyzes the decarboxylation of orotidine monophosphate (OMP), producing uridine monophosphate (UMP).
• KEGG Pathway:
  Pyrimidine metabolism (mtc00240)
  Metabolic pathways (mtc01100)
  Biosynthesis of cofactors (mtc01240)

Molecular Interaction Atlas (MIA) of This DTT

5 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
6-amino-uridine monophosphate	DMUZOYN	Discovery agent	N.A.	Investigative	[2]
6-aza-uridine monophosphate	DM7WYCM	Discovery agent	N.A.	Investigative	[2]
6-Hydroxyuridine-5'-Phosphate	DMDMNQV	Discovery agent	N.A.	Investigative	[1]
Uridine-5'-Monophosphate	DMG1NM7	Discovery agent	N.A.	Investigative	[1]
Xanthosine-5'-monophosphate disodium salt	DM1GJX8	Discovery agent	N.A.	Investigative	[3]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics. J Med Chem. 2006 Aug 10;49(16):4937-45.
• [3] Structural diversity and plasticity associated with nucleotides targeting orotidine monophosphate decarboxylase. J Med Chem. 2008 Feb 14;51(3):432-8.