Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTWT5K7)

DTT Name 5-HT 1 receptor (5HT1R)
Synonyms Serotonin receptor 1; 5-hydroxytryptamine receptor 1; 5-HT1 receptor
Gene Name 5HT1R
DTT Type
Patented-recorded target
 [1]
BioChemical Class
GPCR rhodopsin
UniProt ID
NOUNIPROTAC
TTD ID
T67054

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aryl piperazine derivative 14 DMY8NEL N. A. N. A. Patented [1]
Aryl piperazine derivative 15 DMRK4IE N. A. N. A. Patented [1]
Aryl piperazine derivative 16 DM63XHT N. A. N. A. Patented [1]
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4 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Befiperide DMGAPH1 Anxiety disorder 6B00-6B0Z Terminated [2]
FCE-25876 DMR3ZWA Major depressive disorder 6A70.3 Terminated [3]
RU 24969 DMVW3I9 N. A. N. A. Terminated [4]
SRSS-023 DMUGPDB Migraine 8A80 Terminated [5]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cyanopindolol DMIBLGH Discovery agent N.A. Investigative [6]
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References

1 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.
2 Behavioral Pharmacology of 5-ht. Paul Bevan, Paul Bevan Duphar, Alexander R. Cools. 2013. Figure(15.2).
3 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001389)
4 Effect of chronic treatment with 5-HT1 agonist (8-OH-DPAT and RU 24969) and antagonist (isapirone) drugs on the behavioural responses of mice to 5-HT1 and 5-HT2 agonists. Br J Pharmacol. 1986 Oct;89(2):377-84.
5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019089)
6 The inhibitory effect of serotonin on the spontaneous discharge of suprachiasmatic neurons in hypothalamic slice is mediated by 5-HT(7) receptor. Brain Res Bull. 2001 Mar 1;54(4):395-8.