Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTXMITO)

• DTT Name: SARS-CoV spike glycoprotein S2' HR1 region (S S2'HR1)
• Synonyms: SARS-CoV S glycoprotein S2' heptad repeat 1 region; SARS-CoV Spike glycoprotein S2' heptad repeat 1 region; SARS-CoV E2 S2' heptad repeat 1 region; SARS-CoV Peplomer protein S2' heptad repeat 1 region
• Gene Name: MERS-CoV S
• BioChemical Class: Betacoronaviruses spike protein family.
• UniProt ID: SPIKE_CVHSA (798-1255)
• TTD ID: T11610
• Sequence:
  SFIEDLLFNKVTLADAGFMKQYGECLGDINARDLICAQKFNGLTVLPPLLTDDMIAAYTA
  ALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQ
  ESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDR
  LITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQA
  APHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSWFITQRNFFSPQII
  TTDNTFVSGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINAS
  VVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYVWLGFIAGLIAIVMVTILLC
  CMTSCCSC
• Function: Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.

Molecular Interaction Atlas (MIA) of This DTT

1 Investigative Agents Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fusion peptide EK1	DMP3BZH	Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[1]

References

• [1] A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Sci Adv. 2019 Apr 10;5(4):eaav4580.