Details of the Drug

General Information of Drug (ID: DMP3BZH)

Drug Name

Fusion peptide EK1

Synonyms

EK1 peptide

Indication

Disease Entry	ICD 11	Status	REF
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[1]
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[1]
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Therapeutic Class

Antiviral Agents

Drug Type

Protein/peptide drug

Sequence

SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKEL

Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MERS-CoV spike glycoprotein S2' HR1 region (S S2'HR1)	TT854FJ	A0A140AYZ5_9BETC (888-1353)	Inhibitor	[1]
SARS-CoV spike glycoprotein S2' HR1 region (S S2'HR1)	TTXMITO	SPIKE_CVHSA (798-1255)	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Sci Adv. 2019 Apr 10;5(4):eaav4580.