Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DE4G629)

• DME Name: Succinic semialdehyde reductase (AKR7A2) DME Info
• Gene Name: AKR7A2

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	5.54E-17	4.90E-01	1.10E+00
Alopecia	ED70	Skin from scalp	1.14E-01	-2.01E-03	-9.38E-03
Alzheimer's disease	8A20	Entorhinal cortex	3.13E-01	7.17E-02	2.34E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	1.44E-01	2.47E-01	7.43E-01
Aortic stenosis	BB70	Calcified aortic valve	6.95E-01	-7.30E-02	-6.52E-02
Apnea	7A40	Hyperplastic tonsil	4.50E-01	-2.58E-01	-5.35E-01
Arthropathy	FA00-FA5Z	Peripheral blood	7.31E-02	-2.11E-01	-1.05E+00
Asthma	CA23	Nasal and bronchial airway	4.93E-03	1.57E-01	2.84E-01
Atopic dermatitis	EA80	Skin	2.73E-01	1.12E-01	3.03E-01
Autism	6A02	Whole blood	2.92E-02	-1.09E-01	-3.52E-01
Autoimmune uveitis	9A96	Peripheral monocyte	4.41E-01	1.96E-01	8.07E-01
Autosomal dominant monocytopenia	4B04	Whole blood	2.78E-01	-4.16E-01	-1.05E+00
Bacterial infection of gingival	1C1H	Gingival tissue	3.70E-04	-1.74E-01	-5.33E-01
Batten disease	5C56.1	Whole blood	8.66E-01	8.35E-02	5.93E-01
Behcet's disease	4A62	Peripheral blood	4.54E-01	-5.89E-02	-4.12E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	9.68E-01	-9.34E-03	-3.72E-02
Bladder cancer	2C94	Bladder tissue	2.47E-08	-6.33E-01	-4.45E+00
Breast cancer	2C60-2C6Z	Breast tissue	2.47E-03	-8.74E-02	-2.28E-01
Cardioembolic stroke	8B11.20	Whole blood	9.52E-09	-3.60E-01	-1.82E+00
Cervical cancer	2C77	Cervical tissue	2.42E-01	-3.08E-01	-5.34E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	9.83E-01	-1.14E-01	-1.21E-01
Chronic hepatitis C	1E51.1	Whole blood	1.97E-01	-2.17E-01	-7.06E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	3.10E-01	-1.77E-01	-4.07E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	1.79E-01	1.18E-01	3.87E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	5.82E-02	-6.10E-01	-1.32E+00
Colon cancer	2B90	Colon tissue	4.18E-42	-4.54E-01	-1.44E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	3.02E-01	7.79E-01	1.36E+00
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	8.01E-01	1.46E-01	3.37E-01
Endometriosis	GA10	Endometrium tissue	6.71E-01	-2.18E-02	-4.92E-02
Familial hypercholesterolemia	5C80.00	Peripheral blood	2.79E-01	3.22E-02	3.36E-01
Familial hypercholesterolemia	5C80.00	Whole blood	2.47E-07	6.83E-01	1.68E+00
Gastric cancer	2B72	Gastric tissue	1.26E-01	2.35E-01	1.10E+00
Glioblastopma	2A00.00	Nervous tissue	1.05E-88	6.93E-01	1.68E+00
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	6.04E-01	3.93E-01	5.70E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	2.26E-02	4.30E-01	9.28E-01
Head and neck cancer	2D42	Head and neck tissue	1.96E-10	-3.14E-01	-1.02E+00
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	5.62E-01	8.12E-03	2.22E-02
Huntington's disease	8A01.10	Whole blood	7.32E-01	-1.33E-01	-3.08E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	2.92E-02	6.81E-01	1.58E+00
Immunodeficiency	4A00-4A20	Peripheral blood	7.56E-01	-4.96E-02	-7.36E-01
Influenza	1E30	Whole blood	8.27E-02	-3.40E-01	-1.39E+00
Interstitial cystitis	GC00.3	Bladder tissue	2.41E-02	-1.38E-01	-1.42E+00
Intracranial aneurysm	8B01.0	Intracranial artery	2.73E-03	2.18E-01	1.16E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	4.58E-02	-1.17E-01	-3.28E-01
Ischemic stroke	8B11	Peripheral blood	7.34E-02	-6.10E-02	-3.66E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	7.81E-06	-3.03E-01	-6.37E-01
Lateral sclerosis	8B60.4	Skin	2.05E-01	1.34E-01	1.12E+00
Lateral sclerosis	8B60.4	Cervical spinal cord	9.28E-01	-5.03E-03	-1.07E-02
Liver cancer	2C12.0	Liver tissue	2.79E-07	-2.24E-01	-6.60E-01
Liver failure	DB99.7-DB99.8	Liver tissue	1.61E-01	-3.91E-01	-9.24E-01
Lung cancer	2C25	Lung tissue	4.07E-23	2.29E-01	7.17E-01
Lupus erythematosus	4A40	Whole blood	3.84E-01	6.77E-02	1.41E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	7.93E-01	-1.31E-02	-5.56E-02
Major depressive disorder	6A70-6A7Z	Whole blood	4.70E-01	-6.83E-02	-2.39E-01
Melanoma	2C30	Skin	2.88E-01	1.88E-01	2.54E-01
Multiple myeloma	2A83.1	Peripheral blood	8.35E-01	-1.48E-01	-3.96E-01
Multiple myeloma	2A83.1	Bone marrow	5.70E-06	9.97E-01	3.96E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	1.55E-01	-3.31E-01	-7.02E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	2.56E-01	1.16E-01	2.96E-01
Myelofibrosis	2A20.2	Whole blood	2.26E-02	-1.60E-01	-8.03E-01
Myocardial infarction	BA41-BA50	Peripheral blood	2.40E-03	-3.45E-01	-5.41E-01
Myopathy	8C70.6	Muscle tissue	6.71E-01	1.39E-02	5.41E-02
Neonatal sepsis	KA60	Whole blood	8.61E-11	-2.48E-01	-7.62E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	4.43E-03	5.44E-01	1.73E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	9.80E-01	-2.52E-01	-5.46E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	3.28E-01	2.91E-01	6.53E-01
Olive pollen allergy	CA08.00	Peripheral blood	3.34E-01	3.63E-01	6.42E-01
Oral cancer	2B6E	Oral tissue	9.23E-01	2.08E-01	4.80E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	2.52E-01	6.83E-01	6.56E-01
Osteoporosis	FB83.1	Bone marrow	4.03E-01	1.81E-01	9.81E-01
Ovarian cancer	2C73	Ovarian tissue	7.50E-03	-4.02E-01	-1.41E+00
Pancreatic cancer	2C10	Pancreas	4.51E-01	8.85E-02	1.97E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	7.23E-01	-7.12E-02	-1.90E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	8.57E-01	-5.77E-03	-4.83E-02
Pituitary cancer	2D12	Pituitary tissue	1.24E-02	2.11E-01	6.23E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	1.04E-03	4.95E-01	1.33E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	1.50E-01	1.01E-01	9.65E-01
Polycythemia vera	2A20.4	Whole blood	1.06E-05	-2.28E-01	-1.08E+00
Pompe disease	5C51.3	Biceps muscle	1.83E-02	-1.97E-01	-1.86E+00
Preterm birth	KA21.4Z	Myometrium	2.72E-01	-8.37E-02	-2.82E-01
Prostate cancer	2C82	Prostate	1.94E-02	-3.06E-01	-7.20E-01
Psoriasis	EA90	Skin	3.16E-06	-1.69E-01	-4.77E-01
Rectal cancer	2B92	Rectal colon tissue	1.37E-05	-9.42E-01	-4.34E+00
Renal cancer	2C90-2C91	Kidney	1.99E-02	-1.57E-01	-4.97E-01
Retinoblastoma	2D02.2	Uvea	2.46E-05	7.21E-01	4.99E+00
Rheumatoid arthritis	FA20	Synovial tissue	8.26E-06	6.07E-01	2.90E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	7.94E-01	9.48E-02	4.47E-01
Schizophrenia	6A20	Prefrontal cortex	5.58E-01	1.14E-02	2.51E-02
Schizophrenia	6A20	Superior temporal cortex	1.74E-01	-6.55E-02	-3.03E-01
Scleroderma	4A42.Z	Whole blood	3.21E-03	-1.32E-01	-1.16E+00
Seizure	8A60-8A6Z	Whole blood	6.26E-01	-1.63E-01	-4.07E-01
Sensitive skin	EK0Z	Skin	2.72E-01	-1.08E-01	-6.38E-01
Sepsis with septic shock	1G41	Whole blood	2.67E-28	-3.41E-01	-1.29E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	3.10E-03	-4.42E-01	-1.67E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	4.84E-05	1.90E+00	4.59E+00
Simpson golabi behmel syndrome	LD2C	Adipose tissue	4.04E-01	5.49E-01	1.24E+00
Sjogren's syndrome	4A43.2	Salivary gland tissue	2.70E-01	-2.82E-01	-7.48E-01
Skin cancer	2C30-2C3Z	Skin	1.07E-01	-7.60E-02	-1.86E-01
Thrombocythemia	3B63	Whole blood	2.57E-03	-9.88E-02	-4.93E-01
Thrombocytopenia	3B64	Whole blood	6.19E-01	4.46E-01	4.00E-01
Thyroid cancer	2D10	Thyroid	2.60E-32	-4.54E-01	-1.85E+00
Tibial muscular dystrophy	8C75	Muscle tissue	1.94E-01	-2.21E-01	-6.57E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	5.12E-01	1.83E-01	7.66E-01
Type 2 diabetes	5A11	Liver tissue	3.46E-01	-1.98E-01	-7.39E-01
Ureter cancer	2C92	Urothelium	5.23E-01	-1.24E-01	-5.93E-01
Uterine cancer	2C78	Endometrium tissue	2.53E-22	-6.86E-01	-9.08E-01
Vitiligo	ED63.0	Skin	8.79E-01	4.30E-03	1.67E-02