Details of the Drug-Related molecule(s) Expression Atlas

General Information of DTP (ID: DT48T0N)

• DTP Name: L-type amino acid transporter 1 (SLC7A5) DTP Info
• Gene Name: LAT1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	2.72E-04	3.49E-01	4.69E-01
Adrenocortical carcinoma	2D11.Z	Kidney	1.59E-02	3.59E-01	4.38E-01
Alopecia	ED70	Skin from scalp	4.22E-03	-1.25E-01	-3.70E-01
Alzheimer's disease	8A20	Entorhinal cortex	2.99E-01	1.73E-01	3.72E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	8.94E-01	-1.01E-01	-2.47E-01
Aortic stenosis	BB70	Calcified aortic valve	7.49E-01	1.27E-01	3.81E-01
Apnea	7A40	Hyperplastic tonsil	7.66E-01	2.51E-01	5.15E-01
Arthropathy	FA00-FA5Z	Peripheral blood	5.32E-01	1.75E-01	3.96E-01
Asthma	CA23	Nasal and bronchial airway	9.56E-09	4.27E-01	5.81E-01
Atopic dermatitis	EA80	Skin	1.22E-06	1.01E+00	2.07E+00
Autism	6A02	Whole blood	1.38E-01	1.34E-03	2.97E-03
Autoimmune uveitis	9A96	Peripheral monocyte	1.58E-01	-2.03E+00	-1.61E+00
Autosomal dominant monocytopenia	4B04	Whole blood	1.42E-01	1.58E+00	9.58E-01
Bacterial infection of gingival	1C1H	Gingival tissue	6.32E-09	4.03E-01	8.86E-01
Batten disease	5C56.1	Whole blood	7.57E-01	-6.34E-02	-2.36E-01
Behcet's disease	4A62	Peripheral blood	5.14E-01	-5.07E-02	-1.42E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	2.00E-02	2.15E-01	8.70E-01
Bladder cancer	2C94	Bladder tissue	1.88E-06	1.39E+00	3.59E+00
Breast cancer	2C60-2C6Z	Breast tissue	2.17E-127	1.66E+00	2.39E+00
Cardioembolic stroke	8B11.20	Whole blood	1.04E-01	2.32E-01	3.00E-01
Cervical cancer	2C77	Cervical tissue	1.07E-02	-9.05E-01	-1.11E+00
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	3.13E-01	5.73E-02	1.73E-01
Chronic hepatitis C	1E51.1	Whole blood	4.87E-01	5.07E-01	4.27E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	8.50E-01	1.70E-01	1.79E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	2.96E-04	3.30E-01	8.32E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	3.18E-02	3.37E-01	2.13E+00
Colon cancer	2B90	Colon tissue	2.89E-127	3.10E+00	4.82E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	9.07E-01	1.10E-01	2.40E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	1.52E-01	-1.71E-01	-5.60E-01
Endometriosis	GA10	Endometrium tissue	1.05E-01	3.34E-01	4.44E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	5.34E-01	1.14E-01	3.03E-01
Familial hypercholesterolemia	5C80.00	Whole blood	4.19E-02	-1.69E-01	-3.64E-01
Gastric cancer	2B72	Gastric tissue	3.61E-01	2.81E-01	5.66E-01
Glioblastopma	2A00.00	Nervous tissue	1.38E-06	-8.57E-02	-1.56E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	6.34E-05	8.55E-01	1.76E+00
Head and neck cancer	2D42	Head and neck tissue	5.60E-17	1.72E+00	7.50E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	1.04E-01	5.89E-01	8.03E-01
Huntington's disease	8A01.10	Whole blood	2.12E-01	1.64E-01	9.68E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	3.28E-01	-2.08E-02	-2.11E-02
Immunodeficiency	4A00-4A20	Peripheral blood	9.78E-02	2.24E-01	6.73E-01
Influenza	1.00E+30	Whole blood	7.44E-01	2.34E-01	5.04E-01
Interstitial cystitis	GC00.3	Bladder tissue	1.01E-01	4.51E-01	1.14E+00
Intracranial aneurysm	8B01.0	Intracranial artery	1.34E-01	1.54E+00	9.38E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	3.60E-03	2.71E-01	6.06E-01
Ischemic stroke	8B11	Peripheral blood	2.53E-01	6.97E-01	6.66E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	6.64E-12	5.04E-01	1.04E+00
Lateral sclerosis	8B60.4	Cervical spinal cord	7.99E-01	-2.98E-01	-5.45E-01
Lateral sclerosis	8B60.4	Skin	9.36E-01	-9.02E-02	-8.07E-02
Liver cancer	2C12.0	Liver tissue	6.72E-01	-2.74E-01	-5.61E-01
Liver failure	DB99.7-DB99.8	Liver tissue	1.60E-04	1.49E+00	2.73E+00
Lung cancer	2C25	Lung tissue	7.20E-70	1.66E+00	2.05E+00
Lupus erythematosus	4A40	Whole blood	9.89E-04	-2.09E-01	-2.31E-01
Major depressive disorder	6A70-6A7Z	Whole blood	5.96E-02	6.58E-02	1.67E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	3.88E-01	1.23E-01	5.43E-01
Melanoma	2C30	Skin	3.45E-02	5.95E-01	6.05E-01
Multiple myeloma	2A83.1	Bone marrow	1.68E-06	1.15E+00	3.73E+00
Multiple myeloma	2A83.1	Peripheral blood	7.13E-01	7.20E-02	1.40E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	2.86E-01	-2.39E-01	-7.84E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	6.79E-03	-4.45E-01	-6.29E-01
Myelofibrosis	2A20.2	Whole blood	1.61E-02	1.21E+00	3.80E+00
Myocardial infarction	BA41-BA50	Peripheral blood	1.13E-03	4.34E-01	4.54E-01
Myopathy	8C70.6	Muscle tissue	1.42E-01	-1.62E-01	-3.44E-01
Neonatal sepsis	KA60	Whole blood	1.70E-08	4.37E-01	7.14E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	3.46E-03	-4.51E-01	-1.22E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	2.04E-01	-1.96E-01	-5.33E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	9.52E-01	-6.18E-01	-3.87E-01
Olive pollen allergy	CA08.00	Peripheral blood	9.56E-01	-6.68E-02	-6.30E-02
Oral cancer	2B6E	Oral tissue	2.89E-04	8.46E-01	8.63E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	6.44E-01	3.35E-01	1.35E-01
Osteoporosis	FB83.1	Bone marrow	4.69E-01	5.58E-01	2.16E+00
Ovarian cancer	2C73	Ovarian tissue	2.05E-02	6.97E-01	9.93E-01
Pancreatic cancer	2C10	Pancreas	9.65E-01	1.25E-02	1.41E-02
Parkinson's disease	8A00.0	Substantia nigra tissue	3.35E-01	2.44E-01	6.10E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	6.95E-05	6.34E-01	1.46E+00
Pituitary cancer	2D12	Pituitary tissue	6.40E-02	-4.90E-01	-5.55E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	2.62E-02	-5.31E-01	-5.51E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	4.51E-01	-5.42E-03	-4.58E-02
Polycythemia vera	2A20.4	Whole blood	2.39E-05	4.73E-01	1.39E+00
Pompe disease	5C51.3	Biceps muscle	1.43E-05	8.79E-01	2.77E+00
Preterm birth	KA21.4Z	Myometrium	2.64E-01	-2.50E-01	-3.20E-01
Prostate cancer	2C82	Prostate	2.11E-02	-5.83E-01	-6.52E-01
Psoriasis	EA90	Skin	3.83E-26	1.62E+00	2.00E+00
Rectal cancer	2B92	Rectal colon tissue	2.33E-05	2.32E+00	4.63E+00
Renal cancer	2C90-2C91	Kidney	7.07E-01	7.17E-02	9.91E-02
Retinoblastoma	2D02.2	Uvea	3.80E-08	1.68E+00	3.47E+00
Rheumatoid arthritis	FA20	Synovial tissue	8.17E-04	1.43E+00	2.02E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	4.94E-02	-2.48E-02	-6.49E-02
Schizophrenia	6A20	Prefrontal cortex	7.15E-01	7.04E-02	9.06E-02
Schizophrenia	6A20	Superior temporal cortex	6.53E-01	7.44E-02	2.27E-01
Scleroderma	4A42.Z	Whole blood	6.33E-02	-1.04E-01	-3.37E-01
Seizure	8A60-8A6Z	Whole blood	3.34E-02	-1.97E-01	-3.01E-01
Sensitive skin	EK0Z	Skin	3.30E-02	4.43E-01	1.78E+00
Sepsis with septic shock	1G41	Whole blood	3.39E-30	4.55E-01	1.17E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	4.10E-02	5.57E-01	1.31E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	4.12E-02	2.17E-01	4.21E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	2.02E-02	4.21E-01	1.55E+00
Sjogren's syndrome	4A43.2	Salivary gland tissue	1.97E-01	2.87E-01	1.23E+00
Skin cancer	2C30-2C3Z	Skin	4.40E-70	1.78E+00	1.83E+00
Thrombocythemia	3B63	Whole blood	2.52E-01	2.52E-01	7.98E-01
Thrombocytopenia	3B64	Whole blood	2.32E-01	5.96E-01	1.09E+00
Thyroid cancer	2D10	Thyroid	4.67E-07	5.32E-01	5.93E-01
Tibial muscular dystrophy	8C75	Muscle tissue	1.34E-01	-2.57E-01	-5.21E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	6.69E-01	-1.14E-01	-6.38E-01
Type 2 diabetes	5A11	Liver tissue	6.42E-01	-6.85E-02	-2.31E-01
Ureter cancer	2C92	Urothelium	6.24E-01	1.88E-01	9.09E-01
Uterine cancer	2C78	Endometrium tissue	8.36E-09	1.18E+00	9.42E-01
Vitiligo	ED63.0	Skin	8.18E-01	-2.98E-01	-4.55E-01