Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DE3N2FM)

• DME Name: NADPH-cytochrome P450 reductase (CPR) DME Info
• Gene Name: POR

Molecule-Related Drug & Molecule List

7 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzphetamine	DMIJATC	Obesity	5B81	Approved	[1]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[2]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[3]
Menadiol sodium diphosphate	DMP9N85	Coagulation defect	3B10.0	Approved	[4]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[5]
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[6]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[7]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amrubicin	DM6SGUB	Small-cell lung cancer	2C25.Y	Phase 3	[8]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrobenzodiazepine	DM254EW	N. A.	N. A.	Investigative	[9]

References

• [1] On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol. J Biol Chem. 1985 Jul 15;260(14):8397-403.
• [2] Lack of mechanism-based inactivation of rat hepatic microsomal cytochromes P450 by doxorubicin. Can J Physiol Pharmacol. 1999 Aug;77(8):589-97.
• [3] Kinetics of anthracycline antibiotic free radical formation and reductive glycosidase activity. Arch Biochem Biophys. 1983 May;223(1):68-75.
• [4] Creatinine sulfate/esculoside/hesperidin methyl chalcone/menadiol sodium phosphate/tranexamic acid actions.
• [5] Generation of free radicals during the reductive metabolism of nilutamide by lung microsomes: possible role in the development of lung lesions in patients treated with this anti-androgen. Biochem Pharmacol. 1992 Feb 4;43(3):654-7.
• [6] Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 2008 Mar 15;44(6):1169-79.
• [7] Polymorphisms in cytochrome P450 oxidoreductase and its effect on drug metabolism and efficacy. Pharmacogenet Genomics. 2017 Sep;27(9):337-346.
• [8] Characterization of the enzymes involved in the in vitro metabolism of amrubicin hydrochloride. Xenobiotica. 2005 Dec;35(12):1121-33.
• [9] Flavin-containing reductase: new perspective on the detoxification of nitrobenzodiazepine. Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):967-81.