Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DED5UR3)

• DME Name: Sulfotransferase 1B1 (SULT1B1) DME Info
• Gene Name: SULT1B1

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[1]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[2]
Rotigotine	DMP7X6Q	N. A.	N. A.	Approved	[3]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABT-751	DMNG35S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminophenol	DMEMCQ9	N. A.	N. A.	Investigative	[5]
Mononitrophenol	DM4QO9G	N. A.	N. A.	Investigative	[5]

References

• [1] Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.
• [2] Molecular cloning, expression, and functional characterization of novel mouse sulfotransferases. Biochem Biophys Res Commun. 1998 Jun 29;247(3):681-6.
• [3] Identification of the human SULT enzymes involved in the metabolism of rotigotine. J Clin Pharmacol. 2016 Jun;56(6):754-60.
• [4] Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751. Pharmacogenet Genomics. 2013 Jul;23(7):374-81.
• [5] Comparison of 2-aminophenol and 4-nitrophenol as in vitro probe substrates for the major human hepatic sulfotransferase, SULT1A1, demonstrates improved selectivity with 2-aminophenol. Biochem Pharmacol. 2007 Jul 15;74(2):352-8.