Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DENZ6B1)

• DME Name: UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
• Gene Name: UGT2B15

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[1]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[2]
Lorazepam	DM84ZXF	Absence epilepsy		Approved	[3]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BRN-1980310	DMOTU4P	N. A.	N. A.	Investigative	[4]
Hydroxybenzo(a)pyrene	DM9H5EN	N. A.	N. A.	Investigative	[4]
Hydroxybenzo[a]pyrene	DMFSKYE	N. A.	N. A.	Investigative	[4]

References

• [1] Characterization of niflumic acid as a selective inhibitor of human liver microsomal UDP-glucuronosyltransferase 1A9: application to the reaction phenotyping of acetaminophen glucuronidation. Drug Metab Dispos. 2011 Apr;39(4):644-52.
• [2] Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94.
• [3] Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers. Clin Pharmacol Ther. 2005 Jun;77(6):486-94.
• [4] Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Drug Metab Dispos. 2006 Jun;34(6):943-9.