Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT3TX4H)

• DTP Name: Multidrug and toxin extrusion protein 2 (SLC47A2) DTP Info
• Gene Name: MATE2

Molecule-Related Drug & Molecule List

9 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[1]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[1]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[2]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[1]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[1]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[3]
Metformin	DM89QE1	Colorectal carcinoma		Approved	[1]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[1]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[1]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
N-methylpyridinium	DMVUKEW	N. A.	N. A.	Preclinical	[1]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[1]

References

• [1] Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71.
• [2] FDA Drug Development and Drug Interactions
• [3] Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195.