General Information of Drug (ID: DMH61ZB)

Drug Name
Cimetidine
Synonyms
Acibilin; Acinil; Altramet; Brumetidina; Cimal; Cimetadine; Cimetag; Cimetidina; Cimetidinum; Cimetum; Dyspamet; Edalene; Eureceptor; Evicer; Gastrobitan; Gastromet; Histodil; Magicul; Metracin; Peptol; Sigmetadine; Tagamet; Tametin; Tratul; Ulcedin; Ulcedine; Ulcestop; Ulcimet; Ulcofalk; Ulcomedina; Ulcomet; Ulhys; Valmagen; Venopex; Ci metum; Cimetidine Hcl; Tagamet Hb; Biomet400; C 4522; FPF 1002; SKF 92334; Tagamet Hb 200; CIMETIDINE A/AB; Cimetidina [INN-Spanish]; Cimetidinum [INN-Latin]; DRG-0150; SKF-92334; Tagamet (TN); Tagamet HB (TN); Tagamet HB200 (TN); SK&F-92334; Cimetidine (JP15/USP/INN); Cimetidine [USAN:INN:BAN:JAN]; Tagamet, SKF-92334, Tratul, Tametin, Dyspamet, Acinil, Cimetidine; N-Cyano-N'-methyl-[2-[[[5-methyl-1H-imidazol-4-yl]methyl]thio]ethyl]guanidine; N''-Cyano-N-methyl-N'-[2-[(5-methyl-1H-imidazol-4-yl)methylthio]ethyl]guanidine; N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine; N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine; N-cyano-N'-methyl-N''-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine; N-Cyano-N'-Methyl-N''-(2-(((5-Methyl-1H-Imidazol-4-YL)Methyl)Thio)Ethyl) Guanidine; N-Cyano-N'-methyl-N''-(2-(((5-methyl-1 H-imidazol-4-yl) methyl)thio)ethyl)guanidine; N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine; N''-cyano-N-methyl-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)-ethyl)guanidine; 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine; 1-Cyano-2-methyl-3-[2-[[(5-methylimidazol-4-yl)methyl]thio]ethyl]guanidine; 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine; 2-Cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine; 2-Cyano-1-methyl-3-[2-(5-methyl-1H-imidazol-4-yl-methylthio)ethyl]guanidine; 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine; 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine
Indication
Disease Entry ICD 11 Status REF
Acid-reflux disorder DA22 Approved [1]
Gastric ulcer DA60 Approved [2]
Gastrinoma 2C10.1 Approved [2]
Therapeutic Class
Antiulcer Agents
Affected Organisms
Humans and other mammals
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 252.34
Logarithm of the Partition Coefficient (xlogp) 0.4
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 6-12 h []
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [3]
Bioavailability
The bioavailability of drug is 64-90% []
Clearance
The sytemic clearance of drug is 500-600 mL/min [4]
Elimination
62% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 2 hours [5]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 158.51427 micromolar/kg/day [6]
Unbound Fraction
The unbound fraction of drug in plasma is 0.78% [7]
Vd
The volume of distribution (Vd) of drug is 1 L/kg [4]
Water Solubility
The ability of drug to dissolve in water is measured as 6.2 mg/mL [3]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Haemolytic anaemia Not Available LDHB OT9B1CT3 [8]
Haemolytic anaemia Not Available UGT1A1 OTH1C8OJ [8]
Hyperparathyroidism secondary Not Available PTH OTD721UF [8]
Hyperparathyroidism secondary Not Available PPP3R1 OTGQNFJQ [8]
Thrombocytopenia Not Available LDHC? OTBX9DI5 [8]
Thrombocytopenia Not Available EPHX2 OTPTRCNW [8]
⏷ Show the Full List of 6 ADR Information of This Drug
Chemical Identifiers
Formula
C10H16N6S
IUPAC Name
1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
Canonical SMILES
CC1=C(N=CN1)CSCCNC(=NC)NC#N
InChI
InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
InChIKey
AQIXAKUUQRKLND-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2756
ChEBI ID
CHEBI:3699
CAS Number
51481-61-9
UNII
80061L1WGD
DrugBank ID
DB00501
TTD ID
D02DPA
VARIDT ID
DR00037
INTEDE ID
DR2272
ACDINA ID
D00130
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H2 receptor (H2R) TTQHJ1K HRH2_HUMAN Antagonist [9]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [10]
Multidrug and toxin extrusion protein 2 (SLC47A2) DT3TX4H S47A2_HUMAN Substrate [11]
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [11]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [12]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [13]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [14]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [15]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [16]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [16]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Gene/Protein Processing [17]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [18]
Bifunctional epoxide hydrolase 2 (EPHX2) OTPTRCNW HYES_HUMAN Drug Response [8]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Regulation of Drug Effects [19]
Calcineurin subunit B type 1 (PPP3R1) OTGQNFJQ CANB1_HUMAN Drug Response [8]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Gene/Protein Processing [20]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [17]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [17]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SiMa CTRP2 9.1906 16.9942 4.5089 12.7178
MHH-NB-11 CTRP2 9.632 11.7675 7.3097 1.1895
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 CTRP2 9.4689 11.3288 7.4121 0.9947
SNU-1196 CTRP2 9.5998 11.081 7.5752 0.4458
SNU-478 CTRP2 9.7566 11.3318 7.5463 0.4375
SNU-308 CTRP2 9.9453 11.666 7.4988 0.4588
SNU-1079 CTRP2 10.2114 13.1972 7.0005 1.7082
HuH-28 CTRP2 10.329 11.5315 7.693 0.059
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP2 9.2431 17.2117 3.6388 10.9468
MHH-ES-1 CTRP2 9.6978 12.6978 6.9366 2.4195
SW1353 CTRP2 10.0237 13.9831 6.5453 3.5044
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KPL-1 CTRP2 8.0854 8.7632 6.8037 0.0693
JIMT-1 CTRP2 9.332 11.2439 7.3765 1.2285
CAL-120 CTRP2 9.4171 10.5882 7.6862 0.276
HMC-1-8 CTRP2 9.8081 10.7864 7.7637 0.06
CAMA-1 CTRP2 9.8154 11.3824 7.552 0.3975
CAL-148 CTRP2 10.0835 11.4508 7.6332 0.1615
HCC1954 CTRP2 10.1099 11.956 7.4579 0.4764
HCC1937 CTRP2 10.1128 12.7575 7.1364 1.3547
HCC1806 CTRP2 10.2738 11.5899 7.654 0.1005
MCF-7 CTRP2 10.3135 11.9416 7.5453 0.2354
CAL-51 CTRP2 10.3989 11.9584 7.5715 0.1759
HDQ-P1 CTRP2 10.4129 12.2577 7.4693 0.3356
HCC1395 CTRP2 10.4794 12.0553 7.5672 0.1647
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 9.8444 10.794 7.7736 0.0478
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAS-1 CTRP2 8.4161 9.7935 6.5548 0.4613
SNU-738 CTRP2 8.4428 10.3 7.2536 2.8121
SNU-489 CTRP2 8.6148 10.1091 7.4665 1.6924
SNU-466 CTRP2 9.3785 10.4239 7.7318 0.199
SNU-201 CTRP2 9.6069 10.7525 7.7018 0.1797
LN-18 CTRP2 9.6091 10.3875 7.8289 0.031
SF295 CTRP2 9.6405 10.8825 7.6675 0.2295
SNU-626 CTRP2 9.6915 10.9065 7.6788 0.1934
NMC-G1 CTRP2 9.8845 11.0382 7.7046 0.11
U-87MG ATCC CTRP2 9.9718 11.0767 7.7225 0.0764
SNU-1105 CTRP2 10.1516 11.1606 7.756 0.0332
Daoy CTRP2 10.2495 11.6222 7.6342 0.1265
LN-229 CTRP2 10.3894 11.8419 7.6087 0.1311
GB-1 CTRP2 10.4064 11.7106 7.6596 0.0772
SF126 CTRP2 10.503 11.7339 7.6848 0.0487
ONS-76 CTRP2 10.6472 20.6702 3.7724 13.0456
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 CTRP2 9.3724 11.1031 7.4583 0.9252
HEC-6 CTRP2 9.4179 10.9422 7.5475 0.6241
KLE CTRP2 9.4259 13.7462 6.2724 5.3337
HEC-265 CTRP2 9.4776 10.7144 7.6638 0.2988
HEC-1-B CTRP2 9.6388 11.4788 7.4339 0.8025
HEC-108 CTRP2 9.8175 11.0635 7.6707 0.1714
HEC-59 CTRP2 10.1717 11.3019 7.7159 0.0578
JHUEM-2 CTRP2 10.2542 11.7955 7.575 0.2049
HEC-251 CTRP2 10.4148 11.9179 7.5915 0.1469
Ishikawa (Heraklio) 02 ER- CTRP2 9.6416 10.545 7.7873 0.0602
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-8402 CTRP2 9.0622 11.2946 7.1962 2.1737
JVM-3 CTRP2 9.12 11.7074 7.0398 2.7059
Peer CTRP2 9.2368 11.2401 7.3253 1.499
KMS-27 CTRP2 9.2901 11.7855 7.1096 2.2324
JVM-2 CTRP2 9.4967 13.2612 6.551 4.1303
KMS-26 CTRP2 9.5475 10.4363 7.7911 0.0701
JURL-MK1 CTRP2 9.5484 11.3514 7.4424 0.8408
CML-T1 CTRP2 9.5792 11.244 7.5012 0.6505
P31/FUJ CTRP2 9.5976 10.8588 7.659 0.2609
DEL CTRP2 9.614 10.421 7.8194 0.0369
KCL-22 CTRP2 9.6915 11.5847 7.4158 0.8191
KMS-21-BM CTRP2 9.6928 11.4493 7.4714 0.6618
NALM-6 CTRP2 9.6944 11.2612 7.5466 0.4673
WSU-DLCL2 CTRP2 9.7102 10.6812 7.765 0.0721
KE-37 CTRP2 9.7584 10.9902 7.6744 0.1814
KE-97 CTRP2 9.778 11.2334 7.5928 0.3256
SU-DHL-1 CTRP2 9.796 10.6248 7.8134 0.0262
Ku812 CTRP2 9.863 11.5369 7.5131 0.4643
EM-2 CTRP2 9.9084 11.7732 7.4408 0.6177
HEL CTRP2 9.9124 11.2054 7.656 0.1694
PF-382 CTRP2 9.9539 11.6721 7.5001 0.4517
Jurkat CTRP2 9.9573 11.3752 7.6123 0.2269
KM-H2 CTRP2 9.9771 11.675 7.5088 0.422
P12-Ichikawa CTRP2 10.0332 11.2328 7.6909 0.0996
KHM-1B CTRP2 10.0405 11.4855 7.6046 0.2156
MV4-11 CTRP2 10.0531 11.7446 7.5142 0.3789
HT CTRP2 10.0551 11.3341 7.6637 0.1274
NCI-H929 CTRP2 10.0699 11.3482 7.6642 0.124
LAMA-84 CTRP2 10.1054 12.0722 7.4111 0.5879
EHEB CTRP2 10.1858 11.9633 7.4868 0.3832
KMM-1 CTRP2 10.2222 12.3177 7.3667 0.6364
NCO2 CTRP2 10.4138 12.2782 7.4621 0.3485
Ki-JK CTRP2 10.4187 12.0651 7.5411 0.2144
MOLM-13 CTRP2 10.4778 12.0554 7.5666 0.1658
HDLM-2 CTRP2 10.5505 12.3618 7.4852 0.2664
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TUHR4TKB CTRP2 9.9718 11.4043 7.6074 0.2309
SNU-1272 CTRP2 10.0216 11.4589 7.6069 0.2172
KMRC-20 CTRP2 10.0951 11.6949 7.5497 0.2939
BFTC-909 CTRP2 10.1707 11.5631 7.626 0.1522
OS-RC-2 CTRP2 10.3559 11.9026 7.5752 0.1804
769-P CTRP2 10.515 12.2259 7.5202 0.2215
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LS411N CTRP2 9.3843 10.5767 7.6768 0.3109
SK-CO-1 CTRP2 9.4035 17.5093 4.4154 12.709
DLD-1 CTRP2 9.567 10.4691 7.7868 0.0715
HT-29 CTRP2 9.5804 10.5991 7.7465 0.1182
COLO205 CTRP2 9.6031 11.3676 7.4623 0.7447
SW48 CTRP2 9.6278 11.653 7.356 1.0458
OUMS-23 CTRP2 9.7672 10.806 7.7425 0.0869
HT115 CTRP2 9.9394 11.2297 7.6576 0.1606
LS180 CTRP2 9.96 11.1968 7.6768 0.1297
HCT 116 CTRP2 10.1126 11.5079 7.6239 0.1679
LS513 CTRP2 10.2125 11.6029 7.6274 0.1417
SNU-C2A CTRP2 10.7933 13.2262 7.2627 0.608
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-878 CTRP2 8.5702 14.7085 5.1627 11.2467
Hep 3B2.1-7 CTRP2 9.7874 11.2568 7.5879 0.3321
Li-7 CTRP2 10.2482 14.7912 6.3104 4.1251
SNU-182 CTRP2 10.7396 12.7618 7.4137 0.3303
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2106 CTRP2 8.2699 11.7679 6.3896 6.7206
RERF-LC-Ad1 CTRP2 9.0256 10.2907 7.6248 0.6745
BEN CTRP2 9.1327 9.9954 7.7915 0.1718
MOR/CPR CTRP2 9.1536 9.9571 7.8138 0.1249
SHP-77 CTRP2 9.4017 11.0244 7.5059 0.7562
SBC-5 CTRP2 9.4486 10.5185 7.725 0.1882
NCI-H460 CTRP2 9.5142 10.5612 7.735 0.1517
HCC15 CTRP2 9.5188 13.0366 6.671 3.6329
HCC1588 CTRP2 9.5305 11.1524 7.5154 0.6418
HCC95 CTRP2 9.5583 15.0559 5.7316 7.3095
NCI-H358 CTRP2 9.6366 12.5109 6.9852 2.3079
NCI-H196 CTRP2 9.7041 11.6887 7.3791 0.9183
HCC2108 CTRP2 9.7557 13.383 6.6581 3.3917
NCI-H526 CTRP2 9.8412 11.1223 7.6587 0.1838
LCLC-103H CTRP2 9.8577 10.9103 7.739 0.0765
Lu-99 CTRP2 9.8709 15.7515 5.6122 7.3258
COLO 699 CTRP2 9.9314 12.0506 7.3403 0.8758
NCI-H727 CTRP2 9.9618 12.2702 7.2647 1.0755
NCI-H1734 CTRP2 9.9842 11.6799 7.51 0.4164
NCI-H2009 CTRP2 9.9853 11.6956 7.5045 0.428
NCI-H2291 CTRP2 10.0517 12.0121 7.4109 0.6162
CAL-12T CTRP2 10.0955 11.6962 7.5494 0.2944
NCI-H650 CTRP2 10.1606 11.7789 7.5449 0.2813
HCC827 CTRP2 10.1802 12.2268 7.3837 0.6164
NCI-H1155 CTRP2 10.2039 11.702 7.5893 0.1961
NCI-H292 CTRP2 10.2344 11.7667 7.5778 0.2058
HCC366 CTRP2 10.2534 11.9959 7.502 0.3288
HCC1171 CTRP2 10.2667 12.8486 7.1745 1.1278
HARA [Human squamous cell lung carcinoma] CTRP2 10.2678 12.4943 7.3177 0.7346
NCI-H1581 CTRP2 10.2827 11.754 7.6004 0.1623
NCI-H1975 CTRP2 10.2833 11.9548 7.5288 0.2711
NCI-H69 CTRP2 10.2932 12.115 7.4739 0.3684
NCI-H1838 CTRP2 10.3756 11.9569 7.5633 0.1925
NCI-H211 CTRP2 10.43 12.8537 7.2488 0.8218
HCC78 CTRP2 10.4459 11.9639 7.5868 0.1467
Calu-3 CTRP2 10.4652 12.0352 7.569 0.1652
NCI-H2030 CTRP2 10.4837 12.1831 7.5237 0.2242
A-549 CTRP2 10.6042 12.5338 7.4437 0.3199
RERF-LC-A1 CTRP2 10.6939 12.309 7.5569 0.1372
NCI-H1299 CTRP2 10.7145 12.4986 7.4984 0.2059
NCI-H2405 CTRP2 10.7864 12.8492 7.4002 0.3393
HCC44 CTRP2 10.8045 12.5214 7.5234 0.1561
HCC2279 CTRP2 10.8925 12.7335 7.4816 0.1903
HCC1833 CTRP2 12.7881 23.1274 4.0215 9.332
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 680N CTRP2 9.7761 11.7578 7.3856 0.8493
TE-9 CTRP2 9.9585 11.1621 7.6884 0.1156
TE-10 CTRP2 10.0945 11.6757 7.5565 0.2817
KYSE-180 CTRP2 10.1748 12.0279 7.4579 0.4482
KYSE-140 CTRP2 10.1775 12.4218 7.3055 0.8182
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ES2 CTRP2 9.4595 10.4273 7.7621 0.1243
OVSAHO CTRP2 9.614 13.0211 6.7381 3.257
OVISE CTRP2 9.6884 10.7903 7.7192 0.1316
SNU-119 CTRP2 9.6947 12.2967 7.1138 1.7907
SNU-8 CTRP2 9.8655 10.8476 7.7629 0.0539
Kuramochi CTRP2 10.0874 15.9588 5.6592 6.8367
ONCO-DG-1 CTRP2 10.1405 11.4811 7.6436 0.1356
DOV13 CTRP2 10.1674 11.4628 7.6597 0.1115
JHOC-5 CTRP2 10.2386 11.5382 7.6592 0.1005
OVTOKO CTRP2 10.6387 12.3335 7.5284 0.1821
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HPAF-II CTRP2 7.7034 9.9399 5.2437 1.4021
QGP-1 CTRP2 9.1344 13.9332 5.9764 6.9692
BxPC-3 CTRP2 9.5621 11.6735 7.3134 1.2359
SNU-213 CTRP2 9.689 11.0649 7.6194 0.306
KP-4 CTRP2 9.7471 11.2309 7.5808 0.3638
KP-3 CTRP2 9.7942 13.2196 6.7566 2.977
SUIT-2 CTRP2 10.3716 11.7497 7.634 0.1062
CFPAC-1 CTRP2 10.4136 11.7967 7.6329 0.1011
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ACC-MESO-1 CTRP2 9.6758 10.933 7.663 0.226
NCI-H28 CTRP2 10.0037 11.7201 7.5029 0.4235
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 CTRP2 8.6881 13.2903 4.3154 4.0086
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 9.196 10.3204 7.6942 0.3623
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-7951 CTRP2 9.3605 11.0973 7.4546 0.9464
Mel Ho CTRP2 9.3617 11.0421 7.4786 0.8698
SK-MEL-1 CTRP2 9.5008 10.9922 7.5659 0.523
A-375 CTRP2 10.0026 11.3699 7.6315 0.1835
COLO 741 CTRP2 12.9686 37.1209 -2.5976 25.1592
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh41 CTRP2 10.3988 17.6129 5.0775 8.6481
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GSU CTRP2 8.3197 13.0064 5.8114 9.0443
ECC12 CTRP2 9.0336 10.5602 7.5127 1.0404
MKN1 CTRP2 9.1489 10.5079 6.5838 0.14
GSS CTRP2 9.4576 10.7615 7.6372 0.3679
SNU-620 CTRP2 9.5918 10.6355 7.7379 0.1276
MKN45 CTRP2 9.6467 10.7473 7.7188 0.1421
NCI-N87 CTRP2 9.7465 12.0383 7.2536 1.2758
SNU-5 CTRP2 9.749 10.9943 7.6693 0.1923
NUGC-4 CTRP2 9.765 13.6719 6.5298 3.8703
SNU-668 CTRP2 9.9281 11.1149 7.6937 0.1149
23132/87 CTRP2 9.9611 11.1454 7.6951 0.1071
AGS CTRP2 9.9708 11.1672 7.691 0.1101
SNU-719 CTRP2 10.258 12.5507 7.291 0.8096
KE-39 CTRP2 10.5724 14.2426 6.7413 2.2511
SNU-1077 CTRP2 9.9564 11.9567 7.3898 0.7238
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-62 CTRP2 9.65 11.1166 7.5833 0.402
BHT-101 CTRP2 9.7532 11.0353 7.6561 0.2136
B-CPAP CTRP2 9.786 11.2026 7.6076 0.2927
TT CTRP2 9.787 11.1678 7.6209 0.2665
CGTH-W-1 CTRP2 10.1757 11.5322 7.6387 0.1349
8305C CTRP2 10.2025 11.5231 7.6515 0.1148
8505C CTRP2 10.6185 12.3353 7.5203 0.1972
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-46 CTRP2 9.5794 11.9391 7.2075 1.5767
HSC-3 CTRP2 9.7899 11.0025 7.682 0.1612
Detroit 562 CTRP2 9.9144 11.8121 7.4282 0.647
SNU-1066 CTRP2 9.9342 11.3572 7.6098 0.2382
SNU-1076 CTRP2 9.9975 11.1567 7.7042 0.091
SNU-1214 CTRP2 10.0276 11.8466 7.4646 0.499
YD-10B CTRP2 10.0597 11.2034 7.7103 0.0759
SNU-1041 CTRP2 10.1695 11.9471 7.4861 0.3908
SNU-899 CTRP2 10.2588 11.4115 7.7091 0.0541
BHY CTRP2 10.4854 11.925 7.6144 0.1091
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-29 CTRP2 8.4042 9.7734 7.4834 1.927
JMSU-1 CTRP2 9.0764 10.6284 7.5063 1.0222
253J-BV CTRP2 9.4373 11.0098 7.5292 0.6633
639V CTRP2 9.5523 10.4098 7.8019 0.0586
253J CTRP2 9.5605 10.9255 7.6183 0.3631
KU-19-19 CTRP2 9.9679 11.0825 7.7191 0.0802
BFTC-905 CTRP2 10.0129 11.1422 7.7147 0.0782
5637 CTRP2 10.0438 11.9715 7.4232 0.5897
VM-CUB-1 CTRP2 10.3965 11.9731 7.5654 0.1848
TCCSUP CTRP2 10.4453 11.7812 7.6492 0.0815
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Cimetidine
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Cisapride DMY7PED Major Decreased metabolism of Cimetidine caused by Cisapride mediated inhibition of CYP450 enzyme. Gastro-oesophageal reflux disease [DA22] [21]
Coadministration of a Drug Treating the Disease Different from Cimetidine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Sodium bicarbonate DMMU6BJ Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Sodium bicarbonate. Acidosis [5C73] [22]
Cefuroxime DMSIMD8 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Cefuroxime. Acute bronchitis [CA42] [23]
Repaglinide DM5SXUV Moderate Decreased metabolism of Cimetidine caused by Repaglinide mediated inhibition of CYP450 enzyme. Acute diabete complication [5A2Y] [24]
Glibenclamide DM8JXPZ Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Glibenclamide. Acute diabete complication [5A2Y] [25]
Tolazamide DMIHRNA Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Tolazamide. Acute diabete complication [5A2Y] [25]
Glipizide DMZA5PQ Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Glipizide. Acute diabete complication [5A2Y] [25]
Midostaurin DMI6E0R Moderate Decreased metabolism of Cimetidine caused by Midostaurin mediated inhibition of CYP450 enzyme. Acute myeloid leukaemia [2A60] [26]
Gilteritinib DMTI0ZO Moderate Decreased metabolism of Cimetidine caused by Gilteritinib mediated inhibition of CYP450 enzyme. Acute myeloid leukaemia [2A60] [27]
Galantamine DMEO794 Moderate Antagonize the effect of Cimetidine when combined with Galantamine. Alzheimer disease [8A20] [28]
Rivastigmine DMG629M Moderate Antagonize the effect of Cimetidine when combined with Rivastigmine. Alzheimer disease [8A20] [28]
Donepezil DMIYG7Z Moderate Antagonize the effect of Cimetidine when combined with Donepezil. Alzheimer disease [8A20] [28]
Metronidazole DMTIVEN Minor Decreased metabolism of Cimetidine caused by Metronidazole mediated inhibition of CYP450 enzyme. Amoebiasis [1A36] [29]
Ivabradine DM0L594 Moderate Decreased metabolism of Cimetidine caused by Ivabradine mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [27]
Dronedarone DMA8FS5 Moderate Decreased metabolism of Cimetidine caused by Dronedarone mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [30]
Nifedipine DMSVOZT Moderate Decreased metabolism of Cimetidine caused by Nifedipine mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [31]
Clorazepate DMC3JST Moderate Decreased metabolism of Cimetidine caused by Clorazepate mediated inhibition of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [32]
Methylphenobarbital DMDSWAG Minor Altered absorption of Cimetidine caused by Methylphenobarbital. Anxiety disorder [6B00-6B0Z] [33]
Hydroxyzine DMF8Y74 Minor Decreased metabolism of Cimetidine caused by Hydroxyzine mediated inhibition of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [34]
Halazepam DMPFWO6 Moderate Decreased metabolism of Cimetidine caused by Halazepam mediated inhibition of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [35]
Cilostazol DMZMSCT Moderate Decreased metabolism of Cimetidine caused by Cilostazol mediated inhibition of CYP450 enzyme. Arterial occlusive disease [BD40] [36]
Aminophylline DML2NIB Moderate Decreased metabolism of Cimetidine caused by Aminophylline mediated inhibition of CYP450 enzyme. Asthma [CA23] [37]
Roflumilast DMPGHY8 Moderate Decreased metabolism of Cimetidine caused by Roflumilast mediated inhibition of CYP450 enzyme. Asthma [CA23] [27]
Desipramine DMT2FDC Moderate Decreased metabolism of Cimetidine caused by Desipramine mediated inhibition of CYP450 enzyme. Attention deficit hyperactivity disorder [6A05] [38]
Tindamax DM3OWT4 Minor Decreased metabolism of Cimetidine caused by Tindamax mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [29]
Cefpodoxime DMJUNY5 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Cefpodoxime. Bacterial infection [1A00-1C4Z] [23]
Bacampicillin DMP54C7 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Bacampicillin. Bacterial infection [1A00-1C4Z] [23]
Cefditoren DMSUVM1 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Cefditoren. Bacterial infection [1A00-1C4Z] [39]
Troleandomycin DMUZNIG Moderate Decreased metabolism of Cimetidine caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [40]
Vismodegib DM5IXKQ Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Vismodegib. Basal cell carcinoma [2C32] [40]
Pexidartinib DMS2J0Z Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [41]
Loperamide DMOJZQ9 Major Decreased clearance of Cimetidine due to the transporter inhibition by Loperamide. Bowel habit change [ME05] [42]
Ixabepilone DM2OZ3G Moderate Decreased metabolism of Cimetidine caused by Ixabepilone mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [43]
Lapatinib DM3BH1Y Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Lapatinib. Breast cancer [2C60-2C6Y] [27]
HKI-272 DM6QOVN Major Decreased absorption of Cimetidine due to altered gastric pH caused by HKI-272. Breast cancer [2C60-2C6Y] [40]
Esterified estrogens DM9KZDO Minor Decreased metabolism of Cimetidine caused by Esterified estrogens. Breast cancer [2C60-2C6Y] [44]
Palbociclib DMD7L94 Moderate Decreased metabolism of Cimetidine caused by Palbociclib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [27]
Quinestrol DMJ6H1Z Minor Decreased metabolism of Cimetidine caused by Quinestrol. Breast cancer [2C60-2C6Y] [44]
Tamoxifen DMLB0EZ Major Decreased metabolism of Cimetidine caused by Tamoxifen mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [45]
Toremifene DMQYUWG Moderate Decreased metabolism of Cimetidine caused by Toremifene mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [46]
Bosutinib DMTI8YE Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Bosutinib. Breast cancer [2C60-2C6Y] [27]
Estradiol DMUNTE3 Minor Decreased metabolism of Cimetidine caused by Estradiol. Breast cancer [2C60-2C6Y] [44]
Moricizine DMOMBJW Moderate Decreased metabolism of Cimetidine caused by Moricizine mediated inhibition of CYP450 enzyme. Cardiac arrhythmia [BC9Z] [47]
Atorvastatin DMF28YC Moderate Decreased metabolism of Cimetidine caused by Atorvastatin mediated inhibition of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [48]
Macitentan DMP79A1 Moderate Decreased metabolism of Cimetidine caused by Macitentan mediated inhibition of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [49]
PF-04449913 DMSB068 Moderate Decreased metabolism of Cimetidine caused by PF-04449913 mediated inhibition of CYP450 enzyme. Chronic myelomonocytic leukaemia [2A40] [50]
Anisindione DM2C48U Moderate Decreased metabolism of Cimetidine caused by Anisindione mediated inhibition of CYP450 enzyme. Coagulation defect [3B10] [51]
Irinotecan DMP6SC2 Moderate Decreased metabolism of Cimetidine caused by Irinotecan mediated inhibition of CYP450 enzyme. Colorectal cancer [2B91] [52]
Mestranol DMG3F94 Minor Decreased metabolism of Cimetidine caused by Mestranol. Contraceptive management [QA21] [44]
Levobupivacaine DM783CH Moderate Decreased metabolism of Cimetidine caused by Levobupivacaine mediated inhibition of CYP450 enzyme. Corneal disease [9A76-9A78] [27]
Thiopental DMGP8AX Minor Altered absorption of Cimetidine caused by Thiopental. Corneal disease [9A76-9A78] [33]
Alfentanil DMVO0UB Moderate Decreased metabolism of Cimetidine caused by Alfentanil mediated inhibition of CYP450 enzyme. Corneal disease [9A76-9A78] [53]
Oxtriphylline DMLHSE3 Moderate Decreased metabolism of Cimetidine caused by Oxtriphylline mediated inhibition of CYP450 enzyme. Cough [MD12] [37]
Dextromethorphan DMUDJZM Moderate Decreased metabolism of Cimetidine caused by Dextromethorphan mediated inhibition of CYP450 enzyme. Cough [MD12] [40]
Mifepristone DMGZQEF Moderate Decreased metabolism of Cimetidine caused by Mifepristone mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [54]
Osilodrostat DMIJC9X Moderate Decreased metabolism of Cimetidine caused by Osilodrostat mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [27]
Ivacaftor DMZC1HS Moderate Decreased metabolism of Cimetidine caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [55]
Ethanol DMDRQZU Minor Decreased metabolism of Cimetidine caused by Ethanol mediated inhibition of non-CYP450 enzyme. Cystitis [GC00] [56]
Rivaroxaban DMQMBZ1 Moderate Decreased metabolism of Cimetidine caused by Rivaroxaban mediated inhibition of CYP450 enzyme. Deep vein thrombosis [BD71] [57]
Nortriptyline DM4KDYJ Moderate Decreased metabolism of Cimetidine caused by Nortriptyline mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [38]
Paroxetine DM5PVQE Moderate Decreased metabolism of Cimetidine caused by Paroxetine. Depression [6A70-6A7Z] [58]
Escitalopram DMFK9HG Moderate Decreased metabolism of Cimetidine caused by Escitalopram mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [52]
Desvenlafaxine DMHD4PE Minor Decreased metabolism of Cimetidine caused by Desvenlafaxine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [59]
OPC-34712 DMHG57U Major Decreased metabolism of Cimetidine caused by OPC-34712 mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [60]
Clomipramine DMINRKW Moderate Decreased metabolism of Cimetidine caused by Clomipramine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [38]
Amoxapine DMKITQE Moderate Decreased metabolism of Cimetidine caused by Amoxapine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [38]
Doxepin DMPI98T Moderate Decreased metabolism of Cimetidine caused by Doxepin mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [38]
Polatuzumab vedotin DMF6Y0L Moderate Decreased metabolism of Cimetidine caused by Polatuzumab vedotin mediated inhibition of CYP450 enzyme. Diffuse large B-cell lymphoma [2A81] [61]
[3H]estrone-3-sulphate DMGPF0N Minor Decreased metabolism of Cimetidine caused by [3H]estrone-3-sulphate. Discovery agent [N.A.] [44]
PMID28870136-Compound-49 DMTUC9E Moderate Decreased metabolism of Cimetidine caused by PMID28870136-Compound-49 mediated inhibition of CYP450 enzyme. Discovery agent [N.A.] [62]
Diazepam DM08E9O Moderate Decreased metabolism of Cimetidine caused by Diazepam mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [35]
Zonisamide DM0DTF7 Moderate Decreased metabolism of Cimetidine caused by Zonisamide mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [63]
Primidone DM0WX6I Minor Altered absorption of Cimetidine caused by Primidone. Epilepsy/seizure [8A61-8A6Z] [33]
Stiripentol DMMSDOY Moderate Decreased metabolism of Cimetidine caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [27]
Fosphenytoin DMOX3LB Major Decreased metabolism of Cimetidine caused by Fosphenytoin mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [64]
Clonazepam DMTO13J Moderate Decreased metabolism of Cimetidine caused by Clonazepam mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [35]
Phenobarbital DMXZOCG Minor Altered absorption of Cimetidine caused by Phenobarbital. Epilepsy/seizure [8A61-8A6Z] [33]
Carbamazepine DMZOLBI Moderate Decreased metabolism of Cimetidine caused by Carbamazepine mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [65]
Nicardipine DMCDYW7 Moderate Decreased metabolism of Cimetidine caused by Nicardipine mediated inhibition of CYP450 enzyme. Essential hypertension [BA00] [31]
Nadolol DMW6GVL Moderate Decreased metabolism of Cimetidine caused by Nadolol mediated inhibition of CYP450 enzyme. Essential hypertension [BA00] [66]
Tazemetostat DMWP1BH Moderate Decreased metabolism of Cimetidine caused by Tazemetostat mediated inhibition of CYP450 enzyme. Follicular lymphoma [2A80] [67]
Solifenacin DMG592Q Moderate Decreased metabolism of Cimetidine caused by Solifenacin mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [68]
Mirabegron DMS1GYT Minor Decreased metabolism of Cimetidine caused by Mirabegron mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [69]
Tolterodine DMSHPW8 Moderate Decreased metabolism of Cimetidine caused by Tolterodine mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [70]
Itraconazole DMCR1MV Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Itraconazole. Fungal infection [1F29-1F2F] [71]
Terbinafine DMI6HUW Minor Decreased metabolism of Cimetidine caused by Terbinafine mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [72]
Ketoconazole DMPZI3Q Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Ketoconazole. Fungal infection [1F29-1F2F] [73]
Ripretinib DM958QB Moderate Decreased metabolism of Cimetidine caused by Ripretinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [40]
Avapritinib DMK2GZX Moderate Decreased metabolism of Cimetidine caused by Avapritinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [27]
Carteolol DMFMDOB Moderate Decreased metabolism of Cimetidine caused by Carteolol mediated inhibition of CYP450 enzyme. Glaucoma [9C61] [66]
Colchicine DM2POTE Moderate Decreased metabolism of Cimetidine caused by Colchicine mediated inhibition of CYP450 enzyme. Gout [FA25] [74]
Ergotamine DMKR3C5 Moderate Decreased metabolism of Cimetidine caused by Ergotamine mediated inhibition of CYP450 enzyme. Headache [8A80-8A84] [75]
Carvedilol DMHTEAO Moderate Decreased metabolism of Cimetidine caused by Carvedilol mediated inhibition of CYP450 enzyme. Heart failure [BD10-BD1Z] [66]
MK-1439 DM215WE Minor Decreased metabolism of Cimetidine caused by MK-1439 mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [76]
Delavirdine DM3NF5G Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Delavirdine. Human immunodeficiency virus disease [1C60-1C62] [77]
Fosamprenavir DM4W9B3 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Fosamprenavir. Human immunodeficiency virus disease [1C60-1C62] [78]
Dolutegravir DMCZGRE Minor Decreased metabolism of Cimetidine caused by Dolutegravir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [79]
Etravirine DMGV8QU Moderate Decreased metabolism of Cimetidine caused by Etravirine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [80]
Lopinavir DMITQS0 Minor Decreased metabolism of Cimetidine caused by Lopinavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [27]
Rilpivirine DMJ0QOW Major Decreased absorption of Cimetidine due to altered gastric pH caused by Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [81]
Amprenavir DMLMXE0 Minor Decreased metabolism of Cimetidine caused by Amprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [82]
Atazanavir DMSYRBX Major Decreased absorption of Cimetidine due to altered gastric pH caused by Atazanavir. Human immunodeficiency virus disease [1C60-1C62] [27]
Maraviroc DMTL94F Moderate Decreased clearance of Cimetidine due to the transporter inhibition by Maraviroc. Human immunodeficiency virus disease [1C60-1C62] [83]
Raltegravir DMYURI6 Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Raltegravir. Human immunodeficiency virus disease [1C60-1C62] [84]
Simvastatin DM30SGU Moderate Decreased metabolism of Cimetidine caused by Simvastatin mediated inhibition of CYP450 enzyme. Hyper-lipoproteinaemia [5C80] [48]
BMS-201038 DMQTAGO Moderate Decreased metabolism of Cimetidine caused by BMS-201038 mediated inhibition of CYP450 enzyme. Hyper-lipoproteinaemia [5C80] [85]
Acebutolol DM0TI4U Moderate Decreased metabolism of Cimetidine caused by Acebutolol mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [66]
Bisoprolol DM3UZ95 Moderate Decreased metabolism of Cimetidine caused by Bisoprolol mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [66]
Penbutolol DM4ES8F Moderate Decreased metabolism of Cimetidine caused by Penbutolol mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [66]
Verapamil DMA7PEW Moderate Decreased metabolism of Cimetidine caused by Verapamil mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [31]
Pindolol DMD2NV7 Moderate Decreased metabolism of Cimetidine caused by Pindolol mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [66]
Labetalol DMK8U72 Moderate Decreased metabolism of Cimetidine caused by Labetalol mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [66]
Felodipine DMOSW35 Moderate Decreased metabolism of Cimetidine caused by Felodipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [31]
Pirfenidone DM6VZFQ Moderate Decreased metabolism of Cimetidine caused by Pirfenidone mediated inhibition of CYP450 enzyme. Idiopathic interstitial pneumonitis [CB03] [27]
Retapamulin DM9JXB7 Minor Decreased metabolism of Cimetidine caused by Retapamulin mediated inhibition of CYP450 enzyme. Impetigo [1B72] [86]
Suvorexant DM0E6S3 Moderate Decreased metabolism of Cimetidine caused by Suvorexant mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [40]
Amobarbital DM0GQ8N Minor Altered absorption of Cimetidine caused by Amobarbital. Insomnia [7A00-7A0Z] [33]
Ramelteon DM7IW9J Moderate Decreased metabolism of Cimetidine caused by Ramelteon mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [87]
Flurazepam DMAL4G0 Moderate Decreased metabolism of Cimetidine caused by Flurazepam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [35]
Triazolam DMETYK5 Moderate Decreased metabolism of Cimetidine caused by Triazolam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [35]
Zaleplon DMGFWSM Moderate Decreased metabolism of Cimetidine caused by Zaleplon mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [88]
Melatonin DMKWFBT Minor Decreased metabolism of Cimetidine caused by Melatonin mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [40]
Tasimelteon DMLOQ1V Moderate Decreased metabolism of Cimetidine caused by Tasimelteon mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [89]
ITI-007 DMUQ1DO Moderate Decreased metabolism of Cimetidine caused by ITI-007 mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [90]
Quazepam DMY4D87 Moderate Decreased metabolism of Cimetidine caused by Quazepam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [35]
Estazolam DMZGXUM Moderate Decreased metabolism of Cimetidine caused by Estazolam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [35]
Iron DMAP8MV Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Iron. Iron deficiency anaemia [3A00] [91]
Alosetron DML2A03 Moderate Decreased metabolism of Cimetidine caused by Alosetron mediated inhibition of CYP450 enzyme. Irritable bowel syndrome [DD91] [92]
Naloxegol DML0B41 Minor Decreased metabolism of Cimetidine caused by Naloxegol mediated inhibition of CYP450 enzyme. Large intestine motility disorder [DB32] [93]
Physostigmine DM2N0TO Moderate Antagonize the effect of Cimetidine when combined with Physostigmine. Lips/oral mucosa miscellaneous disorder [DA02] [28]
Pemigatinib DM819JF Moderate Decreased metabolism of Cimetidine caused by Pemigatinib mediated inhibition of CYP450 enzyme. Liver cancer [2C12] [27]
Ceritinib DMB920Z Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Ceritinib. Lung cancer [2C25] [94]
Erlotinib DMCMBHA Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Erlotinib. Lung cancer [2C25] [40]
Lurbinectedin DMEFRTZ Moderate Decreased metabolism of Cimetidine caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [95]
PF-06463922 DMKM7EW Moderate Decreased metabolism of Cimetidine caused by PF-06463922 mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [96]
Dacomitinib DMOH8VY Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Dacomitinib. Lung cancer [2C25] [27]
Osimertinib DMRJLAT Moderate Decreased metabolism of Cimetidine caused by Osimertinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [97]
Pralsetinib DMWU0I2 Moderate Decreased metabolism of Cimetidine caused by Pralsetinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [98]
Selpercatinib DMZR15V Major Decreased absorption of Cimetidine due to altered gastric pH caused by Selpercatinib. Lung cancer [2C25] [27]
Halofantrine DMOMK1V Major Decreased metabolism of Cimetidine caused by Halofantrine mediated inhibition of CYP450 enzyme. Malaria [1F40-1F45] [99]
Chloroquine DMSI5CB Moderate Decreased metabolism of Cimetidine caused by Chloroquine mediated inhibition of CYP450 enzyme. Malaria [1F40-1F45] [27]
Hydroxychloroquine DMSIVND Moderate Decreased metabolism of Cimetidine caused by Hydroxychloroquine mediated inhibition of CYP450 enzyme. Malaria [1F40-1F45] [27]
GDC-0199 DMH0QKA Moderate Decreased metabolism of Cimetidine caused by GDC-0199 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [40]
IPI-145 DMWA24P Moderate Decreased metabolism of Cimetidine caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [100]
Ibrutinib DMHZCPO Moderate Decreased metabolism of Cimetidine caused by Ibrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [101]
Ponatinib DMYGJQO Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Ponatinib. Mature B-cell lymphoma [2A85] [40]
Selumetinib DMC7W6R Moderate Decreased metabolism of Cimetidine caused by Selumetinib mediated inhibition of CYP450 enzyme. Melanoma [2C30] [102]
Dabrafenib DMX6OE3 Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Dabrafenib. Melanoma [2C30] [40]
Estrone DM5T6US Minor Decreased metabolism of Cimetidine caused by Estrone. Menopausal disorder [GA30] [44]
Dienestrol DMBSXI0 Minor Decreased metabolism of Cimetidine caused by Dienestrol. Menopausal disorder [GA30] [44]
Ethinyl estradiol DMODJ40 Minor Decreased metabolism of Cimetidine caused by Ethinyl estradiol. Menopausal disorder [GA30] [44]
Ubrogepant DM749I3 Moderate Decreased metabolism of Cimetidine caused by Ubrogepant mediated inhibition of CYP450 enzyme. Migraine [8A80] [103]
Propranolol DM79NTF Moderate Decreased metabolism of Cimetidine caused by Propranolol mediated inhibition of CYP450 enzyme. Migraine [8A80] [66]
Flibanserin DM70DTN Moderate Decreased metabolism of Cimetidine caused by Flibanserin mediated inhibition of CYP450 enzyme. Mood disorder [6A60-6E23] [104]
Midazolam DMXOELT Moderate Decreased metabolism of Cimetidine caused by Midazolam mediated inhibition of CYP450 enzyme. Mood/affect symptom [MB24] [35]
Panobinostat DM58WKG Moderate Decreased metabolism of Cimetidine caused by Panobinostat mediated inhibition of CYP450 enzyme. Multiple myeloma [2A83] [105]
Thalidomide DM70BU5 Moderate Increased risk of ventricular arrhythmias by the combination of Cimetidine and Thalidomide. Multiple myeloma [2A83] [40]
Siponimod DM2R86O Major Increased risk of atrioventricular block by the combination of Cimetidine and Siponimod. Multiple sclerosis [8A40] [40]
Fingolimod DM5JVAN Moderate Increased risk of bradycardia by the combination of Cimetidine and Fingolimod. Multiple sclerosis [8A40] [106]
Ozanimod DMT6AM2 Moderate Increased risk of atrioventricular block by the combination of Cimetidine and Ozanimod. Multiple sclerosis [8A40] [107]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Cimetidine caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [27]
Nilotinib DM7HXWT Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Nilotinib. Myeloproliferative neoplasm [2A20] [40]
Ruxolitinib DM7Q98D Minor Decreased metabolism of Cimetidine caused by Ruxolitinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [27]
Imatinib DM7RJXL Moderate Decreased metabolism of Cimetidine caused by Imatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [108]
Dasatinib DMJV2EK Major Decreased absorption of Cimetidine due to altered gastric pH caused by Dasatinib. Myeloproliferative neoplasm [2A20] [109]
Prasugrel DM7MT6E Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Prasugrel. Myocardial infarction [BA41-BA43] [110]
Modafinil DMYILBE Minor Decreased metabolism of Cimetidine caused by Modafinil mediated inhibition of CYP450 enzyme. Narcolepsy [7A20] [40]
Dolasetron DMMG26Z Minor Decreased metabolism of Cimetidine caused by Dolasetron mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [111]
Entrectinib DMMPTLH Moderate Decreased metabolism of Cimetidine caused by Entrectinib mediated inhibition of CYP450 enzyme. Non-small cell lung cancer [2C25] [112]
Sibutramine DMFJTDI Minor Decreased metabolism of Cimetidine caused by Sibutramine mediated inhibition of CYP450 enzyme. Obesity [5B80-5B81] [113]
Levomethadyl Acetate DM06HG5 Major Decreased metabolism of Cimetidine caused by Levomethadyl Acetate mediated inhibition of CYP450 enzyme. Opioid use disorder [6C43] [114]
Valdecoxib DMAY7H4 Moderate Decreased metabolism of Cimetidine caused by Valdecoxib mediated inhibition of CYP450 enzyme. Osteoarthritis [FA00-FA05] [115]
Olaparib DM8QB1D Moderate Decreased metabolism of Cimetidine caused by Olaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [116]
Buprenorphine DMPRI8G Moderate Decreased metabolism of Cimetidine caused by Buprenorphine mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [117]
Hydrocodone DMQ2JO5 Major Decreased metabolism of Cimetidine caused by Hydrocodone mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [118]
Mebendazole DMO14SG Minor Decreased metabolism of Cimetidine caused by Mebendazole mediated inhibition of CYP450 enzyme. Parasitic worm infestation [1F90] [119]
Istradefylline DM20VSK Moderate Decreased metabolism of Cimetidine caused by Istradefylline mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [120]
Rasagiline DM3WKQ4 Moderate Decreased metabolism of Cimetidine caused by Rasagiline mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [40]
Pimavanserin DMR7IVC Moderate Decreased metabolism of Cimetidine caused by Pimavanserin mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [121]
Lefamulin DME6G97 Moderate Decreased clearance of Cimetidine due to the transporter inhibition by Lefamulin. Pneumonia [CA40] [122]
Bromfenac DMKB79O Minor Decreased renal excretion of Cimetidine caused by Bromfenac. Postoperative inflammation [1A00-CA43] [123]
Ergonovine DM0VEC1 Moderate Decreased metabolism of Cimetidine caused by Ergonovine mediated inhibition of CYP450 enzyme. Postpartum haemorrhage [JA43] [124]
Lonafarnib DMGM2Z6 Major Decreased metabolism of Cimetidine caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [125]
Darolutamide DMV7YFT Minor Decreased metabolism of Cimetidine caused by Darolutamide mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [126]
Tamsulosin DM5QF9V Moderate Decreased metabolism of Cimetidine caused by Tamsulosin mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [127]
Silodosin DMJSBT6 Moderate Decreased metabolism of Cimetidine caused by Silodosin mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [128]
Dutasteride DMQ4TJK Moderate Decreased metabolism of Cimetidine caused by Dutasteride mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [129]
Bosentan DMIOGBU Moderate Decreased metabolism of Cimetidine caused by Bosentan mediated inhibition of CYP450 enzyme. Pulmonary hypertension [BB01] [130]
Everolimus DM8X2EH Moderate Decreased clearance of Cimetidine due to the transporter inhibition by Everolimus. Renal cell carcinoma [2C90] [131]
Axitinib DMGVH6N Minor Decreased absorption of Cimetidine due to altered gastric pH caused by Axitinib. Renal cell carcinoma [2C90] [132]
Temsirolimus DMS104F Moderate Decreased metabolism of Cimetidine caused by Temsirolimus mediated inhibition of CYP450 enzyme. Renal cell carcinoma [2C90] [133]
Upadacitinib DM32B5U Moderate Decreased metabolism of Cimetidine caused by Upadacitinib mediated inhibition of CYP450 enzyme. Rheumatoid arthritis [FA20] [134]
Thioridazine DM35M8J Major Decreased metabolism of Cimetidine caused by Thioridazine mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [135]
Asenapine DMSQZE2 Moderate Decreased metabolism of Cimetidine caused by Asenapine mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [136]
Pimozide DMW83TP Major Decreased metabolism of Cimetidine caused by Pimozide mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [52]
Tadalafil DMJZHT1 Moderate Decreased metabolism of Cimetidine caused by Tadalafil mediated inhibition of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [137]
LDE225 DMM9F25 Moderate Decreased metabolism of Cimetidine caused by LDE225 mediated inhibition of CYP450 enzyme. Skin cancer [2C30-2C37] [138]
Larotrectinib DM26CQR Moderate Decreased metabolism of Cimetidine caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [40]
Docetaxel DMDI269 Moderate Decreased metabolism of Cimetidine caused by Docetaxel mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [139]
Trabectedin DMG3Y89 Moderate Decreased metabolism of Cimetidine caused by Trabectedin mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [27]
Armodafinil DMGB035 Minor Decreased metabolism of Cimetidine caused by Armodafinil mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [40]
LEE011 DMMX75K Moderate Decreased metabolism of Cimetidine caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [40]
Taxol DMUOT9V Moderate Decreased metabolism of Cimetidine caused by Taxol mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [140]
Pitolisant DM8RFNJ Moderate Decreased metabolism of Cimetidine caused by Pitolisant mediated inhibition of CYP450 enzyme. Somnolence [MG42] [27]
Warfarin DMJYCVW Moderate Decreased metabolism of Cimetidine caused by Warfarin mediated inhibition of CYP450 enzyme. Supraventricular tachyarrhythmia [BC81] [51]
Fostamatinib DM6AUHV Moderate Decreased metabolism of Cimetidine caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [141]
Clopidogrel DMOL54H Moderate Decreased metabolism of Cimetidine caused by Clopidogrel mediated inhibition of CYP450 enzyme. Thrombosis [DB61-GB90] [142]
Tizanidine DMR2IQ4 Major Decreased metabolism of Cimetidine caused by Tizanidine mediated inhibition of CYP450 enzyme. Tonus and reflex abnormality [MB47] [143]
Trimetrexate DMDEA85 Minor Decreased metabolism of Cimetidine caused by Trimetrexate mediated inhibition of CYP450 enzyme. Toxoplasmosis [1F57] [144]
Sirolimus DMGW1ID Moderate Decreased metabolism of Cimetidine caused by Sirolimus mediated inhibition of CYP450 enzyme. Transplant rejection [NE84] [40]
Tacrolimus DMZ7XNQ Moderate Decreased metabolism of Cimetidine caused by Tacrolimus mediated inhibition of CYP450 enzyme. Transplant rejection [NE84] [40]
Saxagliptin DMGXENV Moderate Decreased metabolism of Cimetidine caused by Saxagliptin mediated inhibition of CYP450 enzyme. Type 2 diabetes mellitus [5A11] [27]
Chlorpropamide DMPHZQE Moderate Decreased absorption of Cimetidine due to altered gastric pH caused by Chlorpropamide. Type 2 diabetes mellitus [5A11] [25]
Elagolix DMB2C0E Moderate Decreased metabolism of Cimetidine caused by Elagolix mediated inhibition of CYP450 enzyme. Uterine fibroid [2E86] [145]
Astemizole DM2HN6Q Major Decreased metabolism of Cimetidine caused by Astemizole mediated inhibition of CYP450 enzyme. Vasomotor/allergic rhinitis [CA08] [146]
Procainamide DMNMXR8 Moderate Decreased elimination of Cimetidine caused by Procainamide mediated competitive inhibition of renal tubular secretion. Ventricular tachyarrhythmia [BC71] [147]
Propafenone DMPIBJK Moderate Decreased metabolism of Cimetidine caused by Propafenone mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [148]
Flecainide DMSQDLE Moderate Decreased metabolism of Cimetidine caused by Flecainide mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [149]
⏷ Show the Full List of 217 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
FD&C blue no. 1 E00263 19700 Colorant
Quinoline yellow WS E00309 24671 Colorant
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sunset yellow FCF E00255 17730 Colorant
Vanillin E00049 1183 Flavoring agent
Carmellose sodium E00625 Not Available Disintegrant
Crospovidone E00626 Not Available Disintegrant
Hypromellose E00634 Not Available Coating agent
Magnesium stearate E00208 11177 lubricant
Polysorbate 80 E00665 Not Available Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Sodium alginate E00671 Not Available Binding agent; Disintegrant; Suspending agent; Viscosity-controlling agent
Soybean lecithin E00637 Not Available Other agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Triacetin E00080 5541 Humectant; Plasticizing agent; Solvent
Triethyl citrate E00128 6506 Plasticizing agent; Solvent
⏷ Show the Full List of 17 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Cimetidine 400 mg tablet 400 mg Oral Tablet Oral
Cimetidine 200 mg tablet 200 mg Oral Tablet Oral
Cimetidine 800 mg tablet 800 mg Oral Tablet Oral
Cimetidine 300 mg tablet 300 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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112 Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
113 Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
114 Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
115 Product Information. Bextra (valdecoxib). Pharmacia Corporation, Peapack, NJ.
116 Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
117 Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
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131 Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
132 Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
133 Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
134 Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
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145 Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
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