Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT48T0N)

DTP Name	L-type amino acid transporter 1 (SLC7A5) DTP Info
Gene Name	LAT1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

4 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[1]
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[2]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[3]
Pregabalin	DMDVP3B	Chronic obstructive pulmonary disease	CA22	Approved	[4]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative	[2]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Transport of gabapentin by LAT1 (SLC7A5). Biochem Pharmacol. 2013 Jun 1;85(11):1672-83.
2	Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 6;136(3):521-34.
3	Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. Sci Rep. 2017 Mar 8;7:43580.
4	Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line. Pharm Res. 2018 Oct 29;35(12):246.