Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DTDJEMI)

DTP Name	Proton-coupled folate transporter (SLC46A1) DTP Info
Gene Name	PCFT

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

4 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[2]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[3]
Pralatrexate	DMAO80I	Breast cancer	2C60-2C65	Approved	[4]
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Molecule Interaction Atlas

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References

1	Characterization of uptake of folates by rat and human blood-brain barrier endothelial cells. Biofactors. 2010 May-Jun;36(3):201-9.
2	Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats. J Pharm Pharmacol. 2009 Jul;61(7):911-8.
3	The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol. 2008 Sep;74(3):854-62.
4	Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat. 2012 Aug;15(4):183-210.