General Information of Drug (ID: DMMX2E6)

Drug Name
Pemetrexed
Synonyms
Alimta; LYA; LY 231514; LY231514; Alimta (TN); LY 231,514; LY-2315; LY-231514; Pemetrexed (INN); Pemetrexed [INN:BAN]; LY-231,514; N-(4-(2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid; N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-d-glutamic acid; (2R)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; (2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; 2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID
Indication
Disease Entry ICD 11 Status REF
Central nervous system lymphoma 2B33.5 Approved [1]
Epithelioid mesothelioma 2F10 Approved [1]
Lung cancer 2C25.0 Approved [1]
Malignant pleural mesothelioma 2C26.0 Approved [2]
Non-small-cell lung cancer 2C25.Y Approved [1]
Sarcomatoid mesothelioma N.A. Approved [1]
Small-cell lung cancer 2C25.Y Approved [1]
Lung neoplasm N.A. Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
ATC Code
L01BA04: Pemetrexed
L01BA: Folic acid analogues
L01B: ANTIMETABOLITES
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 427.4
Logarithm of the Partition Coefficient (xlogp) 0.2
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 6
Hydrogen Bond Acceptor Count (hbondacc) 7
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [3]
Clearance
The drug present in the plasma can be removed from the body at the rate of 1.3 mL/min/kg [4]
Elimination
80% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 3.5 hours [4]
Metabolism
The drug is metabolized via the cytochrome P450 Enzymes []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 1.377 micromolar/kg/day [5]
Unbound Fraction
The unbound fraction of drug in plasma is 0.19% [4]
Vd
The volume of distribution (Vd) of drug is 16.1 L []
Water Solubility
The ability of drug to dissolve in water is measured as 90 mg/mL [3]
Chemical Identifiers
Formula
C20H21N5O6
IUPAC Name
(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
Canonical SMILES
C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O
InChI
InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1
InChIKey
WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
Cross-matching ID
PubChem CID
135410875
ChEBI ID
CHEBI:63616
CAS Number
137281-23-3
UNII
04Q9AIZ7NO
DrugBank ID
DB00642
TTD ID
D0Y4GO
VARIDT ID
DR00318
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Candida Thymidylate synthase (Candi TMP1) TTU6BFZ TYSY_CANAL Inhibitor [6]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Folate transporter 1 (SLC19A1) DTOSN46 S19A1_HUMAN Substrate [7]
Proton-coupled folate transporter (SLC46A1) DTDJEMI PCFT_HUMAN Substrate [8]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [9]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [10]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [11]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [12]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ALK tyrosine kinase receptor (ALK) OTV3P4V8 ALK_HUMAN Drug Response [13]
ATP-binding cassette sub-family C member 11 (ABCC11) OTVHL7OR MRP8_HUMAN Drug Response [14]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Drug Response [15]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [16]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) OT1LQSGX MTDC_HUMAN Drug Response [17]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Drug Response [18]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Drug Response [19]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Gene/Protein Processing [20]
Folylpolyglutamate synthase, mitochondrial (FPGS) OTW3F1ZE FOLC_HUMAN Drug Response [21]
Gamma-glutamyl hydrolase (GGH) OTL71J7T GGH_HUMAN Drug Response [21]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 2.9328 5.1144 0.5713 2.3067
EW-13 GDSC1 -4.0066 -2.3756 -4.0077 66.7787
EW-7 GDSC1 -3.2352 4.6052 -4.8045 53.7514
EW-22 GDSC1 -3.1088 1.7759 -3.6374 54.1548
CADO-ES1 GDSC1 -2.724 0.011 -2.8145 50.9246
SK-ES-1 GDSC1 -2.6872 0.9439 -2.9512 50.4538
MHH-ES-1 GDSC1 -2.4986 1.0148 -2.7626 48.4593
EW-3 GDSC1 -1.9328 2.5101 -2.6033 43.3012
ES4 GDSC1 -1.555 4.0588 -2.819 41.171
ES7 GDSC1 -1.3779 5.9804 -3.4991 41.6042
ES1 GDSC1 0.1303 6.0066 -2.0559 29.1493
EW-18 GDSC1 0.4882 9.1589 -3.2902 32.4188
ES8 GDSC1 1.0856 5.4402 -0.9155 18.4237
SK-PN-DW GDSC1 1.4063 5.4523 -0.6502 15.354
EW-1 GDSC1 1.5556 6.611 -1.107 17.9119
EW-24 GDSC1 1.7922 6.8712 -1.047 16.6897
TC-71 GDSC1 2.3792 4.1885 0.6744 2.6101
SJSA-1 GDSC1 2.5252 5.4877 0.1645 5.893
ES6 GDSC1 2.9909 9.6631 -1.5263 15.8943
SaOS-2 GDSC1 3.0055 4.8595 0.7136 1.3966
CAL-78 GDSC1 3.2585 5.3652 0.6278 1.5437
HuO-3N1 GDSC1 3.3656 5.5683 0.5959 1.5834
CAL-72 GDSC1 3.3857 5.3405 0.6951 1.0816
G-292 clone A141B1 GDSC1 3.5531 6.6617 0.2332 3.3821
MG-63 GDSC1 3.6496 5.4433 0.7661 0.5969
EW-16 GDSC1 3.7247 9.0771 -0.7543 9.3392
CHSA8926 GDSC1 3.7627 5.5213 0.7818 0.4829
HOS GDSC1 4.0935 5.619 0.8682 0.1667
HuO9 GDSC1 4.5344 6.7649 0.6306 0.5424
NOS-1 [Human HNSCC] GDSC1 4.5886 6.7599 0.6526 0.4602
NY GDSC1 4.6618 6.4279 0.7925 0.1631
A-673 GDSC1 5.1568 6.3861 2.9573 0.2744
U2OS GDSC1; CTRP1 10.1127 12.85 7.2176 1.9035
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 159 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 1.4813 5.4673 -0.5961 14.6935
ALL-PO GDSC1 -7.6204 -1.6707 -7.8104 83.3025
NKM-1 GDSC1 -6.0603 1.7242 -6.5251 80.2776
HAL-01 GDSC1 -5.4281 -3.3859 -5.4294 82.0309
RCH-ACV GDSC1 -5.2805 -3.5991 -5.2807 81.4711
Reh GDSC1 -5.1563 5.3836 -6.557 70.9466
BV-173 GDSC1 -5.0413 -3.2567 -5.0419 78.6505
P30/OHK GDSC1 -4.7644 6.0741 -6.373 68.8789
H9 GDSC1 -4.5715 5.1009 -6.4154 60.119
NALM-6 GDSC1 -4.5632 -2.9404 -4.5637 73.4591
Ku812 GDSC1; CTRP1 -4.4534 3.647 -4.954 75.7134
MOLT-4 GDSC1 -4.1307 -2.9529 -4.1307 91.4086
SU-DHL-5 GDSC1; CTRP1 -4.0325 -3.2425 -4.0325 82.4176
697 GDSC1 -3.8029 2.012 -4.466 59.1647
WIL2 NS GDSC1 -3.6026 0.286 -3.8053 59.6383
RPMI-8402 GDSC1 -3.5394 10.5733 -6.8853 60.7544
RPMI-8866 GDSC1 -3.4352 3.3865 -4.0638 68.9423
MV4-11 GDSC1 -3.3175 1.1392 -3.4633 73.7318
LAMA-84 GDSC1 -3.2655 4.5324 -4.8068 53.9603
DoHH2 GDSC1 -3.2266 -2.3031 -3.2266 57.2832
KOPN-8 GDSC1 -3.1863 -1.1092 -3.2017 56.5764
CML-T1 GDSC1 -3.1535 -1.2741 -3.1622 56.2457
DND-41 GDSC1 -3.1216 0.9157 -3.4177 54.7455
A3/Kawakami GDSC1 -3.0596 -1.6574 -3.0609 55.1757
MY-M12 GDSC1 -3.0545 18.3999 -10.003 56.0577
KE-37 GDSC1 -3.0431 -1.9535 -3.0433 54.9876
ML-2 GDSC1 -3.0174 0.5187 -3.217 53.9458
NB4 GDSC1 -2.9421 0.1637 -3.0712 53.3103
P32/ISH GDSC1 -2.8792 -1.5703 -2.8802 52.9349
JSC-1 GDSC1 -2.7133 1.6632 -3.1724 50.6622
BL-41 GDSC1 -2.5958 0.5702 -2.7704 49.4699
SCC-3 GDSC1 -2.412 -0.8351 -2.4195 47.1242
SUP-T1 GDSC1 -2.3762 2.2158 -2.6294 65.6803
ATN-1 GDSC1 -2.3285 -0.8888 -2.3332 46.0763
HEL GDSC1 -2.1124 1.3513 -2.4278 44.3448
BC-3 GDSC1 -2.0855 0.4997 -2.2055 43.4871
VAL GDSC1 -1.8518 3.303 -2.8179 43.1785
IM-9 GDSC1 -1.7522 0.742 -1.8903 39.5537
TK [Human B-cell lymphoma] GDSC1 -1.6867 1.8124 -2.0995 39.916
RS4;11 GDSC1 -1.6589 1.6598 -2.022 39.4099
CESS GDSC1 -1.5591 19.5134 -9.112 52.3501
Sc-1 GDSC1 -1.3864 3.606 -2.4518 39.0359
Karpas-231 GDSC1 -1.2063 0.8509 -1.3204 32.7302
P12-Ichikawa GDSC1 -1.1308 16.9829 -7.4815 51.4481
BALL-1 GDSC1 -1.0224 4.268 -1.6991 53.2176
GA-10 GDSC1 -0.931 8.2319 -4.1342 40.559
CTV-1 GDSC1 -0.8873 1.3427 -1.0885 29.3192
TUR GDSC1 -0.8627 7.1334 -3.5402 39.0277
RPMI-6666 GDSC1 -0.8022 6.6849 -3.2674 38.062
EB2 GDSC1 -0.6954 2.9082 -1.4378 30.2671
L-540 GDSC1 -0.5844 2.7831 -1.2696 28.65
DEL GDSC1 -0.578 4.6891 -2.1072 32.9378
MHH-PREB-1 GDSC1 -0.5777 3.6803 -1.648 30.7386
HC-1 GDSC1 -0.2771 3.0585 -1.0665 25.6996
SU-DHL-8 GDSC1 -0.22 4.5446 -1.6868 29.0249
BC-1 GDSC1 -0.1226 3.9645 -1.3197 26.4616
SU-DHL-10 GDSC1 -0.1109 8.0092 -3.2602 34.8122
CTB-1 GDSC1 -0.0953 8.5023 -3.4885 35.402
NOMO-1 GDSC1; CTRP1 -0.0216 281.5884 -135.3984 50.3519
MOLM-13 GDSC1 0.0547 3.1932 -0.7882 22.1392
GR-ST GDSC1 0.1163 5.6411 -1.8907 28.4136
MOLT-13 GDSC1 0.2314 10.4138 -4.1411 35.7656
L-428 GDSC1 0.4457 4.3731 -0.965 21.4747
Karpas-299 GDSC1 0.4639 4.6218 -1.069 22.0766
Mono-Mac-6 GDSC1 0.4773 11.5961 -4.5134 35.7235
SUP-HD1 GDSC1 0.5243 4.6194 -1.0117 21.4299
CCRF-CEM GDSC1 0.5375 13.3091 -4.1281 45.1253
SUP-M2 GDSC1 0.5569 5.5748 -1.4514 24.0233
MEG-01 GDSC1 0.6602 39.9746 -17.2456 48.1863
Raji GDSC1 0.697 7.6835 -2.3723 28.1163
SUP-B15 GDSC1 0.7208 5.0382 -1.038 20.7437
ST486 GDSC1 0.7664 8.4681 -2.7025 29.2165
JURL-MK1 GDSC1 1.0137 16.4695 -5.2421 44.287
Jiyoye GDSC1 1.0776 5.9378 -1.1708 20.1309
SIG-M5 GDSC1 1.2422 4.1194 -0.1215 12.0337
SU-DHL-1 GDSC1 1.2954 5.1989 -0.6161 15.5228
SR GDSC1 1.317 5.4035 -0.7003 16.0411
Granta-519 GDSC1 1.324 6.6446 -1.3149 20.0758
PF-382 GDSC1 1.5156 14.6691 -3.899 41.3867
EM-2 GDSC1 1.5896 7.0609 -1.3041 19.0298
Hs 445 GDSC1 1.7205 5.72 -0.5301 13.3792
SU-DHL-16 GDSC1 1.8558 8.5 -1.8084 20.9984
RC-K8 GDSC1 1.8614 6.3177 -0.7172 14.231
Loucy GDSC1 1.8894 13.2677 -4.1613 30.2268
OPM-2 GDSC1 1.9169 6.4649 -0.7473 14.2558
MOLP-8 GDSC1 1.9272 5.8728 -0.4457 12.083
Ramos.2G6.4C10 GDSC1 1.9739 5.8062 -0.3774 11.436
HL-60 GDSC1 2.04 9.41 -0.8272 32.7315
Jurkat GDSC1 2.0529 10.3088 -2.5536 23.9767
THP-1 GDSC1; CTRP1 2.0745 9.8104 1.0175 43.2149
KCL-22 GDSC1 2.0901 7.5805 -1.1675 16.4653
OCI-Ly19 GDSC1 2.1296 7.0631 -0.8812 14.4764
ARH-77 GDSC1 2.1405 4.5722 0.3455 5.5326
RL GDSC1 2.1652 6.1677 -0.4132 11.1034
DB GDSC1 2.1668 7.2409 -0.941 14.7554
ALL-SIL GDSC1 2.1882 6.0913 -0.3589 10.6409
OCI-AML-2 GDSC1 2.2105 8.2704 -1.4173 17.6049
SU-DHL-6 GDSC1 2.2381 7.383 -0.9576 14.6399
L-363 GDSC1 2.2536 4.0321 0.6715 2.8849
HH [Human lymphoma] GDSC1 2.4033 9.1798 -1.721 18.7313
EoL-1 GDSC1 2.604 10.0415 -1.9955 19.5757
KY821 GDSC1 2.6866 21.9368 -6.4978 40.7636
EHEB GDSC1 2.7553 7.0035 -0.4038 9.37
CA46 GDSC1 2.7757 7.3978 -0.5791 10.5264
OCI-M1 GDSC1 2.7758 4.0817 0.9175 0.6523
OCI-AML-5 GDSC1 2.8105 3.8361 1.0224 0.2532
KMS-12-BM GDSC1 2.8405 8.1774 -0.9107 12.5585
WSU-NHL GDSC1 2.8462 5.8692 0.1873 4.9979
ME1 GDSC1 2.9935 4.1236 0.9891 0.261
Farage GDSC1 3.0458 4.4427 0.8936 0.5385
Karpas-422 GDSC1 3.0487 5.5897 0.4279 3.0057
YT GDSC1 3.0741 6.8305 -0.1163 6.5942
L-1236 GDSC1 3.226 5.6173 0.5082 2.2435
BE-13 GDSC1 3.2785 9.2115 -1.1079 12.63
JVM-3 GDSC1 3.2865 12.7516 -2.8238 21.4803
Karpas-620 GDSC1 3.3635 4.5378 0.9795 0.1544
JJN-3 GDSC1 3.3697 4.9133 0.8495 0.4861
SK-MM-2 GDSC1 3.5306 5.3614 0.7485 0.7392
NK-92MI GDSC1 3.5561 5.0759 0.8625 0.352
MN-60 GDSC1 3.6506 5.7585 0.6483 1.0494
Karpas-45 GDSC1 3.6861 5.2073 0.8644 0.294
MOLT-16 GDSC1 3.6927 5.0069 0.9356 0.1488
LC4-1 GDSC1 3.807 13.7028 -1.4464 28.2532
DG-75 GDSC1 3.8266 5.712 0.7376 0.5864
WSU-DLCL2 GDSC1; CTRP1 3.8911 6.4786 3.8324 29.2723
ROS-50 GDSC1 3.9338 6.8924 0.327 2.3086
KMOE-2 GDSC1 3.9388 9.5434 -0.8377 9.3825
KM-H2 GDSC1 3.9826 5.6125 0.8313 0.265
Daudi GDSC1 3.9956 5.4575 0.8887 0.1559
U266B1 GDSC1 4.146 15.4167 -2.0292 25.8514
HDLM-2 GDSC1 4.2015 6.1512 0.7233 0.4403
JVM-2 GDSC1 4.2094 6.7232 0.5168 1.1336
VL51 GDSC1 4.2605 5.8731 0.8405 0.1737
KG-1 GDSC1 4.2769 5.9872 0.8075 0.2257
PL-21 GDSC1 4.4001 6.2082 0.7757 0.2514
KE-97 CTRP1 4.6965 6.833 3.9387 13.7513
BL-70 CTRP1 5.2552 7.0173 4.3433 7.6177
MLMA GDSC1 5.288 8.6211 2.106 4.6514
MC116 GDSC1; CTRP1 5.3188 6.7149 4.5458 3.2742
P31/FUJ GDSC1 5.3659 6.364 3.0386 0.0676
U-698-M GDSC1 5.3861 10.1005 1.4882 8.5494
SKM-1 GDSC1; CTRP1 5.6168 8.1032 5.4083 18.1889
HT GDSC1; CTRP1 5.6912 10.5925 2.9081 11.0472
P3HR-1 CTRP1 5.8623 7.7706 4.4236 4.7916
QIMR-WIL GDSC1 5.9078 14.9238 -0.464 18.2682
U-937 CTRP1 6.5475 9.8138 5.7996 29.1723
K-562 GDSC1 6.8231 19.3559 -1.971 22.0332
KMS-11 GDSC1; CTRP1 6.9844 13.9886 4.2447 19.097
MOLM-16 CTRP1 7.3463 12.6106 5.2538 27.8966
OCI-Ly10 CTRP1 7.9751 9.6494 7.2859 9.3462
NU-DUL-1 GDSC1; CTRP1 8.16 14.5296 5.0081 13.5775
PL21 CTRP1 8.5032 10.1177 7.4876 5.3862
RPMI-8226 GDSC1; CTRP1 8.9259 12.4399 6.6576 5.3186
GDM-1 GDSC1; CTRP1 9.2312 11.1622 7.4726 1.6099
SU-DHL-4 GDSC1; CTRP1 9.5984 10.804 7.8077 0.2827
EJM GDSC1; CTRP1 9.6544 11.4922 7.5585 0.9212
OCI-AML-3 GDSC1; CTRP1 9.6862 11.0709 7.7431 0.3889
AMO1 GDSC1; CTRP1 9.7874 10.9254 7.8383 0.1618
LP-1 GDSC1; CTRP1 10.1897 11.5383 7.7719 0.1609
⏷ Show the Full List of 159 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1 2.8507 6.283 -0.0011 6.3028
ESO-26 GDSC1 3.4156 7.9557 -0.426 7.9161
FLO-1 GDSC1 4.483 13.8455 -0.9816 24.4267
KYAE-1 GDSC1 5.1356 9.9929 1.3778 9.8834
OACM5.1 C GDSC1 5.3815 9.4494 1.7862 6.582
KYSE-50 GDSC1 5.4688 8.0011 2.4687 2.1348
KYSE-220 GDSC1 5.4856 14.8323 -0.7186 20.4953
TE-12 GDSC1 5.7865 10.6241 1.4923 7.6409
OACP4 C GDSC1 6.4441 14.6272 0.0395 14.547
SK-GT-4 GDSC1 6.5396 9.9064 2.201 2.247
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 3.3247 11.5916 -2.2282 18.6746
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC-IXC GDSC1 -5.183 -2.9033 -5.1868 78.9248
CHP-134 GDSC1 -2.2028 12.5417 -7.4226 48.4044
Kelly GDSC1 -0.1769 7.5192 -3.0806 34.5535
MHH-NB-11 GDSC1 1.5433 7.1955 -1.4091 19.8335
KP-N-YS GDSC1 1.9213 7.3614 -1.1895 17.163
SiMa GDSC1 2.0112 9.9892 -2.4274 23.5471
GI-ME-N GDSC1 2.1542 14.3145 -4.4705 30.3011
SJNB-14 GDSC1 2.4658 5.4014 0.1667 6.023
TGW GDSC1 2.6956 5.0228 0.4821 3.2903
IMR-5 GDSC1 2.7936 8.5567 -1.1279 14.0724
SK-N-BE(2)-M17 GDSC1 3.0896 9.4756 -1.3654 14.6861
SK-N-AS GDSC1 3.1334 4.69 0.8368 0.6928
SK-N-DZ GDSC1 3.2342 5.0835 0.7288 1.0729
SJNB-10 GDSC1 3.2712 8.4878 -0.7678 10.5001
NB1 GDSC1 3.2899 4.9582 0.8007 0.7157
LA-N-6 GDSC1 3.2905 5.7534 0.4836 2.2939
SJNB-7 GDSC1 3.3058 5.5609 0.5707 1.7881
KP-N-YN GDSC1 3.31 5.5356 0.583 1.7168
NB(TU)1 GDSC1 3.4036 4.9803 0.8384 0.5027
SJNB-6 GDSC1 3.4533 5.2272 0.7671 0.7245
CHP-212 GDSC1 3.5141 5.2396 0.787 0.6096
SK-N-FI GDSC1 3.6408 5.0157 0.9144 0.2005
SJNB-13 GDSC1 3.6633 5.6981 0.6767 0.9207
SJNB-5 GDSC1 3.7976 5.6785 0.7384 0.6005
SK-N-SH GDSC1 3.8537 5.8607 0.6938 0.7182
NB69 GDSC1 3.9995 5.7882 0.7762 0.3882
NH-12 GDSC1 5.3457 8.2416 2.3045 3.2809
GOTO GDSC1 5.7208 15.058 -0.6604 19.6273
SJNB-12 GDSC1 6.2187 7.9729 2.7918 0.2183
SJNB-17 GDSC1 6.3653 8.1544 2.7817 0.2496
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 2.6275 8.706 -1.3206 15.7375
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1806 GDSC1 -2.2685 40.1317 -19.9064 52.0961
MRK-nu-1 GDSC1 1.7641 25.0195 -8.8293 44.4024
HCC1599 GDSC1 2.4556 18.8752 -5.166 40.0049
MDA-MB-157 GDSC1 2.6078 6.0195 -0.033 7.1156
HCC2157 GDSC1 2.874 5.2438 0.484 2.9503
BT-483 GDSC1 3.5634 5.5257 0.7002 0.905
UACC-812 GDSC1 3.6591 5.317 0.8155 0.4355
HCC1500 GDSC1 3.6713 5.249 0.8443 0.3501
HCC202 GDSC1 3.8809 5.9895 0.657 0.834
T-47D GDSC1 4.2455 6.7256 0.5309 1.0499
UACC-893 GDSC1 4.274 6.2757 0.7064 0.4536
CAL-85-1 GDSC1 4.2904 12.4822 -1.9926 15.0653
HCC1419 GDSC1 4.5096 6.7305 2.5057 3.5013
CAL-120 GDSC1 5.0953 6.326 2.9555 0.3071
AU565 GDSC1 5.1044 17.9423 -2.5361 27.8963
BT-474 GDSC1 5.165 6.8137 2.8031 0.8062
YMB-1-E GDSC1 5.1895 20.9295 -3.9533 31.1141
Evsa-T GDSC1 5.1967 6.6713 2.8697 0.5237
MDA-MB-468 GDSC1 5.1985 7.0065 2.7431 1.0414
HCC1428 GDSC1 5.2646 6.8388 2.835 0.6033
HCC2218 GDSC1 5.2801 12.7304 0.1595 16.8255
MDA-MB-175-VII GDSC1 5.4908 7.0138 2.8599 0.3894
MDA-MB-361 GDSC1 5.5563 7.7743 2.6009 1.3513
MDA-MB-415 GDSC1 5.5671 7.1996 2.8224 0.462
MFM-223 GDSC1 5.6177 6.9796 2.9185 0.199
ZR-75-30 GDSC1 5.6947 7.4173 2.7931 0.4842
CAMA-1 GDSC1 5.7317 7.153 2.8996 0.2029
HCC1954 GDSC1 5.7584 7.5679 2.7633 0.5423
HCC38 GDSC1 5.7619 7.6073 2.7504 0.5821
HCC1187 GDSC1 5.8948 7.5728 2.8132 0.3376
MDA-MB-231 GDSC1 5.9089 7.8062 2.7354 0.5472
HDQ-P1 GDSC1 5.9344 7.4748 2.8614 0.2188
BT-549 GDSC1 5.9664 7.7918 2.7625 0.4391
COLO 824 GDSC1 5.9816 22.3599 -4.0563 29.5401
HCC1395 GDSC1 5.9937 7.5293 2.8637 0.1984
EFM-192A GDSC1 6.0658 7.6745 2.8397 0.2233
CAL-51 GDSC1 6.1279 7.8192 2.8122 0.2591
Hs 578T GDSC1 6.1746 8.0285 2.7565 0.3671
EFM-19 GDSC1 6.1789 13.3143 0.4871 12.7901
HCC1937 GDSC1 6.2077 7.858 2.8272 0.2084
MDA-MB-436 GDSC1 6.2359 7.9535 2.8045 0.2425
BT-20 GDSC1 6.3032 7.8537 2.8616 0.1344
HCC1569 GDSC1 6.3467 8.5629 2.6314 0.6336
OCUB-M GDSC1 6.3627 7.9401 2.8531 0.1351
HCC70 GDSC1 6.4131 8.3633 2.7269 0.3487
DU4475 GDSC1 6.4226 21.0718 -3.0942 26.2767
CAL-148 GDSC1 6.5159 22.135 -3.5478 27.2234
MDA-MB-330 GDSC1 6.524 8.502 2.7189 0.3286
MDA-MB-453 GDSC1 6.9041 17.3765 -0.9632 18.0946
MCF-7 GDSC1; CTRP1 10.5908 19.5684 4.3714 13.3468
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF539 GDSC1 0.7475 7.3215 -2.1477 26.8846
SF268 GDSC1 1.2104 5.2456 -0.7114 16.525
GB-1 GDSC1 2.2975 3.8944 0.7591 2.1988
LN-18 GDSC1 2.3167 3.4701 0.9518 0.9763
D-502MG GDSC1 2.407 4.5441 0.5294 3.5527
D-566MG GDSC1 2.4792 8.0511 -1.1078 14.8673
42-MG-BA GDSC1 2.5469 8.079 -1.0719 14.4368
KINGS-1 GDSC1 2.6882 6.0507 0.0045 6.6482
Hs 683 GDSC1 2.8218 4.3467 0.8343 0.991
SF126 GDSC1 2.8576 9.9034 -1.7399 17.4691
CAS-1 GDSC1 2.8593 7.9144 -0.7706 11.5888
SK-MG-1 GDSC1 2.9484 5.8566 0.2536 4.3326
LN-405 GDSC1 2.9584 4.2002 0.948 0.4032
ONS-76 GDSC1 3.0309 6.9077 -0.179 7.1247
H4 GDSC1 3.0526 5.1721 0.6078 1.916
GI-1 GDSC1 3.1321 5.2217 0.6262 1.7076
PFSK-1 GDSC1 3.1904 7.7958 -0.4935 8.8894
D-263MG GDSC1 3.1971 4.7913 0.8251 0.6902
D-542MG GDSC1 3.2503 4.6123 0.9121 0.3565
NMC-G1 GDSC1 3.2866 4.4218 0.9919 0.1522
KNS-42 GDSC1 3.3067 4.7038 0.9008 0.3615
YKG-1 GDSC1 3.3408 7.4441 -0.2359 6.8168
A-172 GDSC1 3.3494 5.5677 0.5886 1.6403
DK-MG GDSC1 3.3778 4.5153 0.9921 0.129
AM-38 GDSC1 3.3879 5.4377 0.6581 1.2513
U-87MG ATCC GDSC1 3.4205 5.2036 0.7623 0.7673
LNZTA3WT4 GDSC1 3.4477 5.2239 0.766 0.7329
KALS-1 GDSC1 3.472 8.1067 -0.4611 8.0207
DBTRG-05MG GDSC1 3.6162 5.1215 0.8687 0.3106
M059J GDSC1 3.6177 5.421 0.7616 0.6322
Daoy GDSC1 3.629 5.181 0.8525 0.3467
D283 Med GDSC1 3.6331 5.0137 0.9123 0.2068
T98G GDSC1 3.6519 5.4428 0.7672 0.5918
SNB-75 GDSC1 3.6591 6.6759 0.2818 2.9307
KNS-81-FD GDSC1 3.8888 5.9715 0.6669 0.7917
Becker GDSC1 3.9548 5.5164 0.8544 0.2264
Onda 10 GDSC1 3.9771 5.6749 0.8076 0.3196
MOG-G-CCM GDSC1 3.9972 6.5117 0.5074 1.3552
D-247MG GDSC1 4.0438 5.9026 0.7523 0.4321
YH-13 GDSC1 4.1026 5.7069 0.8416 0.2098
U-251MG GDSC1 4.1068 5.664 0.8576 0.1809
8-MG-BA GDSC1 4.1602 5.8464 0.8143 0.2452
SW1783 GDSC1 4.2099 6.4468 0.6201 0.7486
SW1088 GDSC1 4.2904 5.9577 0.8223 0.1964
U-118MG GDSC1 4.4439 6.1907 0.797 0.2023
D-392MG GDSC1 4.4746 6.4008 0.7361 0.3081
D-423MG GDSC1 4.5025 6.5631 0.6899 0.4022
D-336MG GDSC1 4.5171 6.7259 0.6379 0.5299
MOG-G-UVW GDSC1 4.5919 6.3999 0.7778 0.1996
Onda 11 GDSC1 4.6019 6.5905 0.7164 0.3091
KS-1 [Human Krukenberg tumour] GDSC1 4.7044 6.811 0.6771 0.3592
SF295 GDSC1; CTRP1 6.3775 7.8866 4.6734 0.9715
LN-229 GDSC1; CTRP1 6.7713 11.0442 5.4679 14.7787
GaMG GDSC1; CTRP1 7.256 8.8553 4.6834 0.3583
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 3.9652 5.7476 0.7777 0.3987
TGBC1TKB GDSC1 4.0674 5.6333 0.8543 0.1962
ETK-1 GDSC1 6.0206 15.4958 -0.6621 18.8786
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC1 2.6599 7.2064 -0.5666 10.7556
EN GDSC1 3.061 4.8367 0.7484 1.1566
MFE-296 GDSC1 3.2161 5.4687 0.5652 1.9338
AN3-CA GDSC1 4.1103 5.7966 0.8136 0.2616
MFE-280 GDSC1 4.5752 6.696 0.6701 0.4221
RL95-2 GDSC1 5.7711 7.2141 2.8927 0.205
MFE-319 GDSC1; CTRP1 5.9559 8.2967 4.2349 3.6214
HEC-151 CTRP1 6.2872 13.4395 3.8596 39.091
HEC-108 CTRP1 6.3023 8.5141 4.3546 4.1792
HEC-251 CTRP1 6.9921 8.7512 4.6125 1.1715
KLE GDSC1; CTRP1 7.3178 9.1447 4.6009 0.6431
HEC-265 CTRP1 7.3333 8.4028 4.869 0.088
HEC-6 CTRP1 7.3799 8.6552 4.8003 0.1947
HEC-59 CTRP1 7.6067 8.9847 4.7679 0.1939
JHUEM-2 CTRP1 9.2614 11.0827 7.5259 2.9325
Ishikawa (Heraklio) 02 ER- CTRP1 6.1717 8.4429 4.307 4.9007
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TK-10 GDSC1 -0.0814 7.6336 -3.0486 34.0234
769-P GDSC1 1.1537 6.5538 -1.4132 21.3246
ACHN GDSC1 1.4602 6.1542 -0.9567 17.2728
UO-31 GDSC1 2.1192 6.0616 -0.3949 11.1112
HA7-RCC GDSC1 2.6735 7.0953 -0.5036 10.283
KMRC-1 GDSC1 3.0008 5.0663 0.6262 1.8832
786-O GDSC1 3.0714 12.7422 -2.9783 22.7113
KMRC-20 GDSC1 3.1261 6.0828 0.2539 3.9873
BFTC-909 GDSC1 3.2827 4.9233 0.8108 0.6816
LB2241-RCC GDSC1 3.3633 5.8681 0.472 2.2583
A-498 GDSC1 3.3967 4.8562 0.8805 0.376
A-704 GDSC1 3.4109 5.1816 0.7667 0.7575
SW13 GDSC1 3.4771 5.1116 0.8193 0.5223
NCC021 GDSC1 3.5576 5.68 0.6384 1.1765
BB65-RCC GDSC1 3.6005 5.2072 0.8325 0.415
Caki-1 GDSC1 3.6365 9.4749 -0.9965 11.0521
KTCTL-140 GDSC1 3.6941 5.8857 0.618 1.1419
SN12C GDSC1 3.7054 5.386 0.8085 0.4332
RXF 393L GDSC1 3.7278 6.1061 0.547 1.4329
OS-RC-2 GDSC1 3.7971 8.8473 -0.6035 8.2275
KTCTL-26A GDSC1 3.8013 5.617 0.7622 0.5223
KTCTL-195 GDSC1 3.8603 5.499 0.8263 0.3191
LB996-RCC GDSC1 3.8987 5.6002 0.805 0.3563
KTCTL-13 GDSC1 4.0293 5.9535 0.7287 0.5052
CAL-54 GDSC1 4.2306 5.962 0.7998 0.2532
VMRC-RCZ GDSC1 4.282 5.7742 0.8809 0.1135
LB1047-RCC GDSC1 4.4798 6.5411 0.6892 0.4124
KTCTL-1M GDSC1 4.5325 6.556 0.7033 0.36
SW156 GDSC1 4.5388 6.4281 0.7496 0.2621
KTCTL-21 GDSC1 4.643 7.3936 0.4439 1.092
VMRC-RCW GDSC1; CTRP1 6.2113 7.914 4.5727 1.5856
RCC10RGB GDSC1; CTRP1 9.8639 11.1251 7.7958 0.2105
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 320HSR GDSC1 -2.1114 4.899 -3.7564 46.3065
SNU-407 GDSC1 0.699 8.3839 -2.7194 29.5508
SNU-175 GDSC1; CTRP1 0.7392 5.4163 0.6155 50.2763
HCC2998 GDSC1 0.8449 11.8773 -4.3363 34.0412
LS513 GDSC1; CTRP1 1.0571 69.4826 -30.4498 48.5803
SNU-C2B GDSC1 1.7257 7.6964 -1.5115 19.7867
LS1034 GDSC1 2.3108 10.6065 -2.4995 22.9114
SNU-C1 GDSC1 2.4568 7.4291 -0.819 13.0537
SW1463 GDSC1 2.4711 5.8824 -0.0588 7.6541
CCK-81 GDSC1 2.4817 8.5237 -1.3383 16.2832
SW1116 GDSC1 2.6589 4.8393 0.543 2.9548
NCI-H747 GDSC1 2.8978 7.7626 -0.6712 10.8231
GP5d GDSC1 3.2021 5.0606 0.7235 1.1295
SW1417 GDSC1 3.3708 5.0405 0.803 0.6478
HCT 15 GDSC1 3.6652 5.6385 0.6999 0.8269
CaR-1 GDSC1 3.7452 5.5773 0.7548 0.5774
NCI-H716 GDSC1 3.8021 5.5973 0.7696 0.4992
SW837 GDSC1 3.8024 7.6825 -0.0761 4.8705
SW626 GDSC1 3.8214 5.7845 0.709 0.6858
T84 GDSC1 4.1237 5.9664 0.7595 0.3797
LS180 GDSC1; CTRP1 4.315 9.1807 3.6594 28.4835
COLO205 GDSC1; CTRP1 4.6981 8.7772 2.9833 13.1267
SNU-C4 CTRP1 4.7827 15.5799 1.3868 49.6425
CL-11 GDSC1 4.9177 6.8778 0.7296 0.2039
DLD-1 CTRP1 5.2846 6.9776 4.3872 7.1051
SK-CO-1 CTRP1 5.306 7.6045 4.0914 9.6679
SNU-81 GDSC1; CTRP1 5.4119 16.1562 1.7176 30.8806
LS411N GDSC1; CTRP1 5.644 7.9056 4.2041 4.3781
C2BBe1 CTRP1 5.7845 7.9065 4.3049 6.0529
CW-2 GDSC1; CTRP1 6.5436 12.9379 4.3455 19.7702
SW48 GDSC1; CTRP1 6.5993 8.5204 4.5185 1.3696
GP2d CTRP1 7.3122 8.9553 4.669 0.6233
SW403 CTRP1 7.8553 9.4568 4.6946 0.2725
SNU-C2A CTRP1 8.0349 10.4219 4.4169 1.1091
SNU-C5 GDSC1; CTRP1 8.1282 18.8841 2.8043 21.5449
CL-40 CTRP1 8.2471 12.9269 5.882 19.725
KM12 GDSC1; CTRP1 8.526 21.9653 1.5936 24.1801
SW948 GDSC1; CTRP1 8.7842 15.5845 4.9893 12.456
HT115 GDSC1; CTRP1 8.8612 10.7856 7.4157 2.2923
RKO GDSC1; CTRP1 9.1788 12.0029 7.0471 3.3361
SNU-61 GDSC1; CTRP1 9.1928 12.04 7.0387 3.3502
NCI-H508 CTRP1 9.4363 13.0245 6.7316 8.8653
HCT 116 GDSC1; CTRP1 9.4925 10.9677 7.6962 0.6236
SW620 GDSC1; CTRP1 9.5479 11.4197 7.5347 1.0829
MDST8 GDSC1; CTRP1 9.6487 11.6889 7.4722 1.2031
HCT 8 CTRP1 9.688 10.7209 7.8736 0.2831
HT-29 GDSC1; CTRP1 9.8663 11.142 7.7905 0.219
LoVo GDSC1; CTRP1 9.9393 11.8713 7.5405 0.7748
COLO 320 CTRP1 9.971 17.0415 5.1615 18.0572
SNU-1040 GDSC1; CTRP1 9.9741 11.2631 7.7885 0.1904
RCM-1 [Human ESC] GDSC1; CTRP1 10.0095 11.4205 7.7452 0.2545
LS123 GDSC1; CTRP1 10.025 12.3438 7.3875 1.1701
COLO 678 GDSC1; CTRP1 10.1453 12.0635 7.558 0.6075
SW480 CTRP1 10.2018 13.5141 6.9759 5.036
CL-34 CTRP1 10.2396 11.5392 7.79 0.2687
HT-55 GDSC1; CTRP1 10.2871 11.5427 7.8059 0.1001
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 2.5672 5.3357 0.2623 5.0905
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-423 GDSC1 2.5604 9.8706 -1.9438 19.4407
Hep-G2/C3A GDSC1 2.9413 4.3615 0.8809 0.6671
Hep 3B2.1-7 GDSC1 3.0694 5.5278 0.4657 2.736
HuH-1 GDSC1 3.0776 4.4851 0.8907 0.5273
JHH-1 GDSC1 3.2847 4.68 0.9009 0.372
SNU-475 GDSC1 3.3727 4.8404 0.877 0.3984
JHH-2 GDSC1 3.4596 9.5762 -1.1607 12.4884
SK-HEP-1 GDSC1 3.499 4.7404 0.9582 0.1574
HLE GDSC1 3.5534 5.6233 0.6585 1.0907
JHH-4 GDSC1 3.8983 5.5855 0.81 0.3441
SNU-387 GDSC1 4.1663 12.5485 -2.1068 15.9292
JHH-7 GDSC1 4.1938 11.0066 -1.3589 11.8947
Huh-7 GDSC1 4.9697 6.9788 2.6472 1.8064
SNU-449 GDSC1; CTRP1 6.0375 8.1574 4.3552 2.8765
JHH-6 GDSC1; CTRP1 6.3322 7.224 4.9156 0.2088
Hep-G2 CTRP1 10.204 11.5341 7.7787 0.3148
SNU-398 GDSC1; CTRP1 10.839 12.5398 7.6601 0.1716
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 193 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-SL2 GDSC1 -3.5274 -1.7199 -3.5317 60.8407
LC-2/ad GDSC1 -1.1255 6.1186 -3.314 39.8445
NCI-H526 GDSC1 -0.3052 4.5008 -1.7499 29.7935
SBC-1 GDSC1 0.2289 7.1477 -2.5255 30.7506
NCI-H524 GDSC1 0.2742 5.5514 -1.6996 26.688
Lu-99A GDSC1 0.3438 5.8951 -1.8039 26.9203
IST-SL1 GDSC1 1.1716 8.8524 -2.5469 27.0181
PC-14 GDSC1 1.215 7.2256 -1.697 22.7148
COR-L311 GDSC1 1.3055 5.9493 -0.9828 18.0229
NCI-H146 GDSC1 1.394 6.4769 -1.1727 18.9255
CPC-N GDSC1 1.5709 5.0491 -0.3145 12.3085
EMC-BAC-2 GDSC1 1.7669 6.0745 -0.6701 14.2197
COR-L303 GDSC1 1.9262 5.1711 -0.0996 9.519
NCI-H2795 GDSC1 2.006 4.3697 0.3506 5.8592
NCI-H211 GDSC1 2.0386 8.7036 -1.7655 20.1497
SBC-5 GDSC1 2.0462 5.5246 -0.1847 9.788
NCI-H64 GDSC1 2.1463 7.0117 -0.8432 14.1679
NCI-H1770 GDSC1 2.2939 5.9231 -0.2009 9.179
NCI-H2444 GDSC1 2.3298 3.7395 0.8447 1.5896
NCI-H520 GDSC1 2.3333 5.236 0.1577 6.4249
NCI-H2369 GDSC1 2.354 5.5355 0.0282 7.3267
NCI-H69 GDSC1 2.3924 8.1954 -1.2429 15.9761
Lu-139 GDSC1 2.4152 6.9067 -0.5937 11.6381
SK-MES-1 GDSC1 2.4561 4.45 0.6013 2.9544
SBC-3 GDSC1 2.6458 5.2268 0.3608 4.2209
NCI-H209 GDSC1 2.6517 10.0739 -1.9757 19.3303
NCI-H2810 GDSC1 2.6618 5.3512 0.3134 4.5174
LK-2 GDSC1 2.6711 8.9561 -1.4115 16.1502
NCI-H3122 GDSC1 2.6973 8.8892 -1.3596 15.7651
NCI-H292 GDSC1 2.7077 5.8272 0.1216 5.7678
HOP-62 GDSC1 2.7257 5.67 0.2056 5.1335
NCI-H187 GDSC1 2.7338 6.4183 -0.1395 7.5619
NCI-H1304 GDSC1 2.7987 7.6241 -0.6723 11.0968
NCI-H2228 GDSC1 2.8122 6.0473 0.0845 5.7903
NCI-H720 GDSC1 2.8149 4.3868 0.8151 1.0943
NCI-H345 GDSC1 2.8408 3.6809 1.0872 0.0974
NCI-H226 GDSC1 2.8608 11.6717 -2.6076 21.7383
NCI-H2171 GDSC1 2.9648 4.5628 0.8133 0.9445
COR-L321 GDSC1 3.0406 4.8183 0.7464 1.1884
NCI-H196 GDSC1 3.1616 4.2812 0.9956 0.1816
NCI-H2591 GDSC1 3.1639 5.3788 0.5769 1.9387
NCI-H1341 GDSC1 3.192 7.0339 -0.1378 6.48
NCI-H838 GDSC1 3.1964 4.4673 0.9433 0.2941
LB647-SCLC GDSC1 3.1977 5.0381 0.7303 1.1015
NCI-H1436 GDSC1 3.2102 4.7426 0.8487 0.5904
NCI-H2731 GDSC1 3.216 5.9006 0.3828 3.0097
NCI-H513 GDSC1 3.2219 9.7876 -1.4242 14.6703
NCI-H2722 GDSC1 3.2261 5.1081 0.7155 1.1431
NCI-H2818 GDSC1 3.2272 5.0795 0.7272 1.0869
NCI-H322M GDSC1 3.2346 5.4336 0.5886 1.7811
NCI-H510A GDSC1 3.238 13.3619 -3.1597 22.9747
RERF-LC-MS GDSC1 3.2561 9.1181 -1.0784 12.506
NCI-H2804 GDSC1 3.3019 9.4227 -1.1934 13.0905
NCI-H2196 GDSC1 3.3192 7.8884 -0.455 8.328
NCI-H2373 GDSC1 3.3313 5.7592 0.5014 2.1358
NCI-H1688 GDSC1 3.362 5.3979 0.6622 1.258
NCI-H2803 GDSC1 3.3641 6.5556 0.1776 4.0473
NCI-H2461 GDSC1 3.3812 7.1607 -0.0827 5.7121
EMC-BAC-1 GDSC1 3.4109 11.6077 -2.1745 18.1797
DMS 53 GDSC1 3.4168 5.2071 0.7595 0.7812
Lu-165 GDSC1 3.4264 5.0485 0.8224 0.5424
NCI-H1869 GDSC1 3.4747 5.1983 0.7865 0.6374
ABC-1 GDSC1 3.4775 5.819 0.5471 1.7045
NCI-H2291 GDSC1 3.4857 5.7723 0.5697 1.5799
NCI-H2595 GDSC1 3.5151 7.0947 0.0237 4.7592
NCI-H847 GDSC1 3.522 5.1095 0.8376 0.4397
NCI-H2135 GDSC1 3.5543 5.0906 0.8566 0.3689
Ms-1 GDSC1 3.5846 5.4909 0.7221 0.8008
Lu-135 GDSC1 3.6158 5.2768 0.8134 0.464
NCI-H1838 GDSC1 3.622 5.8647 0.5947 1.3151
NCI-H1581 GDSC1 3.6249 5.1358 0.8669 0.3116
NCI-H1155 GDSC1 3.6313 4.969 0.9269 0.1792
NCI-H1993 GDSC1 3.6341 5.099 0.8832 0.2691
NCI-H290 GDSC1 3.6963 5.3711 0.8103 0.4323
NCI-H2066 GDSC1 3.7127 5.5577 0.7491 0.6157
NCI-H1563 GDSC1 3.713 5.3968 0.8075 0.4322
NCI-H446 GDSC1 3.7199 5.4388 0.795 0.4653
NCI-H1734 GDSC1 3.721 5.8351 0.6489 0.9877
UMC-11 GDSC1 3.8217 5.4684 0.8229 0.3426
PaCa-3 GDSC1 3.8394 7.4714 0.0359 4.1168
IA-LM GDSC1 3.9112 5.3687 0.8894 0.1742
LOU-NH91 GDSC1 3.9382 5.3322 0.911 0.1343
DMS 114 GDSC1 3.9486 5.448 0.8755 0.1889
NCI-H647 GDSC1 3.9714 5.9907 0.6928 0.6486
NCI-H1651 GDSC1 3.9844 6.259 0.5985 0.9828
SW1573 GDSC1 4.0112 6.3769 0.5651 1.0962
NCI-H2087 GDSC1 4.0238 6.5356 0.5097 1.321
NCI-H2085 GDSC1 4.1266 5.913 0.7792 0.3312
NCI-H1650 GDSC1 4.1326 6.4122 0.6019 0.863
SW1271 GDSC1 4.1457 5.8799 0.7976 0.2838
NCI-H1092 GDSC1 4.2109 13.8023 -2.6784 18.4857
NCI-H1703 GDSC1 4.2284 6.3441 0.6646 0.5944
NCI-H1623 GDSC1 4.253 5.8304 0.8522 0.1573
Lu-134-A GDSC1 4.2765 6.48 0.6341 0.6635
Lu-99 CTRP1 4.4237 6.2022 3.9673 14.9326
COR-L279 CTRP1 4.4309 6.7994 3.6993 17.1689
NCI-H2170 GDSC1 4.465 6.4272 0.7235 0.3382
NCI-H2869 GDSC1 4.4885 6.7304 0.6255 0.5785
NCI-H1648 GDSC1 4.5804 6.6813 0.6771 0.4033
EKVX GDSC1 4.5894 6.6921 0.6767 0.4009
NCI-H2347 GDSC1 4.5965 6.6019 0.7105 0.3229
A-427 GDSC1 4.599 6.8404 0.6281 0.5198
COR-L105 GDSC1 4.8404 6.8409 0.7152 0.2451
RERF-LC-Sq1 GDSC1 5.1323 7.1573 0.7097 0.1898
NCI-H1568 GDSC1; CTRP1 5.5751 7.5595 4.3235 3.8938
NCI-H2009 GDSC1; CTRP1 5.6913 9.0205 3.6891 6.9849
EBC-1 GDSC1; CTRP1 5.7498 8.9862 3.7503 6.5392
BEN GDSC1; CTRP1 5.8962 9.2039 3.7516 6.2309
NCI-H82 GDSC1; CTRP1 6.059 7.9386 4.4711 2.2743
NCI-H810 GDSC1; CTRP1 6.119 7.9619 4.4971 2.061
NCI-H1373 CTRP1 6.1888 7.8658 4.5813 2.6673
VMRC-LCD CTRP1 6.2162 7.8827 4.5893 2.5481
NCI-H2286 CTRP1 6.2382 8.3615 4.3859 4.0866
SHP-77 GDSC1; CTRP1 6.2635 11.9938 2.6506 11.0954
LCLC-103H GDSC1; CTRP1 6.2899 7.944 4.603 1.3563
KNS-62 GDSC1; CTRP1 6.6775 8.766 4.4542 1.5512
NCI-H522 GDSC1; CTRP1 6.6852 8.4972 4.5716 1.0749
NCI-H1437 GDSC1; CTRP1 6.7304 9.278 4.2593 2.3328
NCI-H358 GDSC1; CTRP1 6.7563 11.956 3.022 8.2924
NCI-H1435 GDSC1; CTRP1 6.8455 8.532 4.6332 0.7261
NCI-H1048 GDSC1; CTRP1 6.8536 12.8053 2.6791 9.7851
DMS 273 GDSC1; CTRP1 6.897 8.4696 4.6803 0.5459
HCC33 GDSC1; CTRP1 6.94 8.4076 4.7219 0.4073
HCC78 GDSC1; CTRP1 6.9749 16.8649 0.7796 17.8003
NCI-H2126 CTRP1 7.0039 8.3577 4.7659 0.4657
NCI-H1930 CTRP1 7.0309 8.4547 4.7411 0.5406
Calu-6 GDSC1; CTRP1 7.0562 8.5138 4.7295 0.3356
HARA [Human squamous cell lung carcinoma] GDSC1; CTRP1 7.1563 11.5379 3.4831 5.3618
NCI-H2029 GDSC1; CTRP1 7.198 8.6467 4.7365 0.266
LC-1/sq-SF CTRP1 7.2043 8.3009 4.8589 0.1298
NCI-H1666 GDSC1; CTRP1 7.2616 13.2446 2.7465 8.722
EPLC-272H GDSC1; CTRP1 7.2892 9.3818 4.4971 0.8575
NCI-H1963 CTRP1 7.3006 10.9636 6.0172 23.2645
RERF-LC-KJ GDSC1; CTRP1 7.3454 8.9696 4.6768 0.3375
Lu-65 GDSC1; CTRP1 7.4002 8.9174 4.7165 0.2391
NCI-H1975 GDSC1; CTRP1 7.4111 9.0033 4.69 0.2862
NCI-H650 GDSC1; CTRP1 7.4168 9.2311 4.6091 0.465
NCI-H1573 GDSC1; CTRP1 7.4203 9.0112 4.6907 0.2817
HCC44 GDSC1; CTRP1 7.4438 9.4277 4.5464 0.6157
DV-90 CTRP1 7.5431 9.1154 4.6998 0.3847
COLO 668 GDSC1; CTRP1 7.5621 9.6939 4.4949 0.6941
NCI-H2405 GDSC1; CTRP1 7.5681 9.3017 4.643 0.3267
LXF 289 GDSC1; CTRP1 7.5727 9.3129 4.6407 0.3298
NCI-H1792 GDSC1; CTRP1 7.5987 9.0621 4.7386 0.1534
NCI-H23 GDSC1; CTRP1 7.6143 9.3993 4.6256 0.3462
NCI-H1793 GDSC1; CTRP1 7.6319 9.0326 4.7605 0.119
COR-L88 GDSC1; CTRP1 7.7123 9.193 4.7342 0.1369
A-549 GDSC1; CTRP1 7.7172 9.9571 4.4602 0.7051
NCI-H1915 GDSC1; CTRP1 7.7181 9.3686 4.6756 0.2208
LCLC-97TM1 GDSC1; CTRP1 7.755 10.0593 4.4372 0.7486
NCI-H1355 GDSC1; CTRP1 7.764 9.8388 4.5239 0.5155
NCI-H1299 GDSC1; CTRP1 7.7879 15.0024 2.2592 10.067
ChaGo-K-1 GDSC1; CTRP1 7.8037 9.8974 4.5182 0.5116
NCI-H727 GDSC1; CTRP1 7.9241 9.8381 4.5865 0.3187
Calu-3 GDSC1; CTRP1 7.9255 9.6801 4.6427 0.2209
NCI-H661 GDSC1; CTRP1 7.953 9.8863 4.5803 0.3213
NCI-H1944 GDSC1; CTRP1 8.1497 10.2852 4.5125 0.3887
NCI-H1105 GDSC1; CTRP1 8.2703 10.0107 7.359 3.4957
NCI-H2110 GDSC1; CTRP1 8.6776 11.2301 7.0693 4.0029
NCI-H2141 GDSC1; CTRP1 9.1526 10.8128 7.5844 1.2836
NCI-H841 GDSC1; CTRP1 9.2226 11.6668 7.2346 2.5317
NCI-H2122 GDSC1; CTRP1 9.2459 18.5474 3.8768 15.8189
NCI-H2073 CTRP1 9.2587 11.4047 7.3785 4.0962
NCI-H596 GDSC1; CTRP1 9.3237 11.5456 7.3531 1.953
HCC2108 CTRP1 9.3556 11.0834 7.5778 2.3506
SCLC-21H CTRP1 9.5768 10.9264 7.7514 0.8993
NCI-H1781 GDSC1; CTRP1 9.7057 11.0771 7.749 0.3659
NCI-H1876 GDSC1; CTRP1 9.764 11.9934 7.4021 1.3364
SK-LU-1 GDSC1; CTRP1 9.7784 11.9596 7.4241 1.2511
NCI-H2023 GDSC1; CTRP1 9.8097 11.6142 7.5837 0.7365
T3M-10 CTRP1 9.8163 12.9766 6.9946 5.7643
Sq-1 CTRP1 9.8685 11.3603 7.71 0.8078
CAL-12T GDSC1; CTRP1 9.8733 11.6021 7.618 0.6035
HCC1833 CTRP1 9.9013 12.9773 7.0442 5.1861
COR-L23 GDSC1; CTRP1 9.9061 11.3508 7.7293 0.3232
HCC827 GDSC1; CTRP1 9.9149 11.7013 7.5975 0.6336
NCI-H1694 GDSC1; CTRP1 9.9818 11.4672 7.7167 0.3193
NCI-H460 GDSC1; CTRP1 9.9835 11.1259 7.8406 0.1135
HCC1195 CTRP1 10.0619 11.3811 7.7797 0.3834
COR-L51 CTRP1 10.0776 12.0651 7.5269 1.5418
NCI-H2172 GDSC1; CTRP1 10.0931 11.8801 7.6065 0.5153
NCI-H3255 GDSC1; CTRP1 10.1227 11.6966 7.6886 0.3226
NCI-H2081 GDSC1; CTRP1 10.1357 11.7502 7.6739 0.3471
NCI-H1836 GDSC1; CTRP1 10.2613 11.6411 7.7623 0.1581
HCC2935 CTRP1 10.3088 12.2451 7.5588 1.1116
HCC15 GDSC1; CTRP1 10.3189 12.9574 7.2776 1.2876
NCI-H441 GDSC1; CTRP1 10.3242 11.9296 7.6831 0.2649
NCI-H1755 GDSC1; CTRP1 10.3507 12.044 7.6517 0.3127
HCC1359 CTRP1 10.4071 21.1894 3.4474 24.6291
NCI-H2030 GDSC1; CTRP1 10.4613 12.0692 7.6855 0.222
NCI-H2342 GDSC1; CTRP1 10.7791 12.3187 7.7148 0.119
HCC4006 CTRP1 10.9653 21.3317 3.7789 21.8418
COLO 699 CTRP1 11.0065 19.645 4.6213 17.9671
⏷ Show the Full List of 193 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 4.483 6.4615 0.7182 0.3439
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-270 GDSC1 0.3893 7.0802 -1.3234 42.6057
TE-15 GDSC1 0.9846 6.3315 -1.4476 22.1998
OE33 GDSC1 2.4866 10.124 -2.125 20.5898
TE-9 GDSC1 2.8498 4.9919 0.5804 2.3834
TE-11 GDSC1 2.9112 4.5384 0.7988 1.0695
TE-10 GDSC1 3.097 5.2072 0.6151 1.8145
OE21 GDSC1 3.1591 5.9864 0.3148 3.5338
EC-GI-10 GDSC1 3.523 5.0907 0.8447 0.418
TE-4 GDSC1 4.8922 12.5803 -0.0468 18.986
TE-5 GDSC1 4.9164 6.9963 2.6131 2.0815
OE19 GDSC1 5.2107 16.3881 -3.2411 18.5413
KYSE-70 GDSC1 5.3824 10.1188 1.4774 8.6294
KYSE-520 GDSC1 5.4897 7.4943 2.6808 1.05
KYSE-510 GDSC1 5.6709 7.376 2.7988 0.4793
COLO 680N GDSC1 5.9982 17.7497 -1.7752 23.2784
TE-8 GDSC1 6.0927 11.2583 1.3856 7.6813
KYSE-180 GDSC1 6.1135 7.8739 2.7881 0.3156
T.T GDSC1 6.1829 7.795 2.8399 0.1926
KYSE-150 GDSC1 6.264 31.0397 -8.1432 35.2866
TE-1 GDSC1 6.5927 8.3219 2.8042 0.1597
KYSE-450 GDSC1; CTRP1 7.2158 8.5291 4.7848 0.2078
KYSE-140 GDSC1; CTRP1 7.3592 29.0984 -4.9941 33.1509
KYSE-410 GDSC1; CTRP1 7.9991 9.9511 4.5746 0.382
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OC 314 GDSC1 1.0443 6.1807 -1.3207 21.1984
Caov-4 GDSC1 2.3935 12.6762 -3.4643 26.5028
ES-2 GDSC1 2.4317 6.5664 -0.4161 10.3413
TOV-112D GDSC1 2.7443 7.4966 -0.6484 11.0828
TOV-21G GDSC1 2.7683 4.7537 0.6398 2.1486
OV56 GDSC1 2.8126 3.8534 1.017 0.2675
OVISE GDSC1 3.1121 4.2669 0.9826 0.2285
FU-OV-1 GDSC1 3.4726 5.5828 0.6389 1.2567
JHOS-2 GDSC1 3.4764 5.3968 0.7125 0.9255
DOV13 GDSC1 3.5481 5.0552 0.8668 0.344
OVCAR-5 GDSC1 3.7763 5.5793 0.7662 0.5236
OVCAR-3 GDSC1 3.8606 6.5624 0.4261 1.8817
OVTOKO GDSC1 4.1617 6.0688 0.7376 0.4199
OAW28 GDSC1 4.1763 5.9358 0.7893 0.2915
Kuramochi GDSC1 4.3165 7.2654 0.3539 1.7486
HEY A8 CTRP1 5.5964 8.2815 3.9827 9.5135
COV318 CTRP1 6.9814 7.7743 4.958 0.0379
OVMANA CTRP1 7.0673 8.367 4.7868 0.3578
EFO-21 GDSC1; CTRP1 7.4379 8.8371 4.7585 0.1599
SK-OV-3 GDSC1; CTRP1 7.5835 9.0003 4.7544 0.1353
JHOS-4 GDSC1; CTRP1 7.6009 9.4666 4.5959 0.4162
OV-90 GDSC1; CTRP1 8.0499 15.3052 4.5277 15.6949
Caov-3 GDSC1; CTRP1 8.3225 9.6301 7.591 2.4146
OVK18 GDSC1; CTRP1 8.642 18.1387 3.6005 17.9152
OVKATE GDSC1; CTRP1 8.8433 12.0737 6.7767 4.9553
A2780 GDSC1; CTRP1 9.399 13.3338 6.5581 5.0042
IGROV-1 GDSC1; CTRP1 9.4586 11.3803 7.5042 1.2652
JHOM-1 CTRP1 9.5099 12.9526 6.8144 7.9886
SNU-840 CTRP1 9.6867 14.238 6.3197 11.3116
JHOC-5 CTRP1 9.8236 11.9571 7.4484 2.4078
COV362 CTRP1 9.9756 11.8352 7.5719 1.4139
EFO-27 GDSC1; CTRP1 10.0324 12.2599 7.4261 1.046
COV434 CTRP1 10.2335 14.555 6.5229 8.3
OV7 CTRP1 10.292 11.8429 7.702 0.5142
OAW42 GDSC1; CTRP1 10.3513 11.4485 7.8599 0.0458
RMG-I GDSC1; CTRP1 10.3931 12.9907 7.3002 1.1656
TYK-nu GDSC1; CTRP1 10.4297 12.215 7.6202 0.3448
COV644 CTRP1 10.5467 11.9537 7.7573 0.2348
RMUG-S CTRP1 10.5685 18.4024 4.9198 17.6296
OVCAR-8 GDSC1; CTRP1 11.8519 26.2754 2.0027 17.4868
OVCAR-4 GDSC1; CTRP1 13.7767 28.2312 2.3711 13.8671
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-PC-1 GDSC1 1.0168 8.5858 -2.5452 27.5965
PSN1 GDSC1 1.075 6.2273 -1.3176 21.0571
Panc 08.13 GDSC1 2.087 4.7907 0.2033 6.7492
SU.86.86 GDSC1 2.4219 6.2761 -0.2822 9.4095
Panc 04.03 GDSC1 2.5381 5.4697 0.1812 5.7414
HuP-T3 GDSC1 2.698 7.7249 -0.7911 12.1706
YAPC GDSC1 2.8614 10.2439 -1.9042 18.3383
PaTu 8988t GDSC1 2.8636 6.0896 0.0966 5.5901
Capan-1 GDSC1 2.9288 6.4447 -0.0275 6.3087
BxPC-3 GDSC1 3.0123 9.7073 -1.5326 15.8707
KP-1N GDSC1 3.1611 5.7614 0.4136 2.9085
AsPC-1 GDSC1 3.3638 6.4362 0.2297 3.7171
DAN-G GDSC1 3.5199 5.2477 0.7864 0.6081
PL4 GDSC1 3.5933 5.4088 0.7563 0.6668
MIA PaCa-2 GDSC1 3.5972 4.8294 0.9623 0.1277
SW1990 GDSC1 3.7144 10.2954 -1.3339 12.8805
HPAF-II GDSC1 3.9497 6.8214 0.3633 2.0993
Hs 766T GDSC1 4.1088 5.9204 0.7701 0.3594
KP-4 GDSC1 4.409 13.2299 -2.2698 16.1465
Panc 02.03 GDSC1 4.7045 13.0052 -1.9704 14.0125
SUIT-2 GDSC1; CTRP1 5.4258 7.3202 4.3285 4.1861
QGP-1 GDSC1; CTRP1 5.9362 10.0042 3.3875 8.0423
PaTu 8902 GDSC1; CTRP1 5.9696 8.1877 4.2963 3.2865
CFPAC-1 GDSC1; CTRP1 6.3137 10.4385 3.4482 6.9794
Panc 03.27 GDSC1; CTRP1 6.5257 9.6093 3.9858 3.9102
KP-3 GDSC1; CTRP1 6.5484 10.0331 3.8014 4.781
Panc 10.05 GDSC1; CTRP1 7.146 8.929 4.6105 0.6023
HPAC GDSC1; CTRP1 7.4512 8.887 4.746 0.1757
HuP-T4 GDSC1; CTRP1 7.7184 9.4986 4.6297 0.3022
Capan-2 GDSC1; CTRP1 8.0603 9.7447 4.6688 0.155
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 3.5792 5.2533 0.8077 0.5014
NCI-H2452 GDSC1 3.5966 7.9296 -0.3043 6.7269
IST-Mes1 GDSC1 4.1286 5.8293 0.8089 0.2655
MSTO-211H GDSC1; CTRP1 4.7244 6.7406 4.0098 7.6794
NCI-H28 GDSC1; CTRP1 6.8069 9.6167 4.1518 2.7194
NCI-H2052 GDSC1; CTRP1 7.3061 9.4736 4.4685 0.9387
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC1 2.4987 7.3325 -0.7416 12.4095
PC-3 GDSC1 3.1947 6.7728 -0.0167 5.6546
VCaP GDSC1 3.3901 5.0819 0.7955 0.6622
LNCaP clone FGC GDSC1 4.306 6.6948 0.5671 0.8721
DU145 GDSC1 4.5419 6.4082 0.7575 0.2467
PaCa-3 CTRP1 6.64 7.9042 4.7872 0.6571
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.1738 5.9963 0.7675 0.3413
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 800 GDSC1 -3.8985 1.732 -4.4853 60.1244
COLO 679 GDSC1 0.7152 10.0719 -3.5467 32.3501
MeWo GDSC1 0.7684 7.8809 -2.4081 27.983
M14 GDSC1 0.8659 10.6008 -3.6808 32.2012
LOX-IMVI GDSC1 1.9321 7.9833 -1.4905 18.9536
Mel Ho GDSC1 2.3841 6.8405 -0.5837 11.6599
CP66-MEL GDSC1 2.4749 5.983 -0.1044 7.9757
WT2-iPS GDSC1 2.5956 6.0844 -0.072 7.4271
LB2518-MEL GDSC1 2.672 3.9432 0.9261 0.7081
COLO 783 GDSC1 2.7593 4.614 0.6946 1.8327
UACC-62 GDSC1 2.7761 4.1642 0.8857 0.7931
SK-MEL-24 GDSC1 2.9598 6.2624 0.0757 5.5245
A101D GDSC1 3.0351 5.8919 0.2875 3.9378
HT-144 GDSC1 3.0685 6.3054 0.1209 4.9861
A2058 GDSC1 3.0834 4.133 1.0187 0.1584
UACC-257 GDSC1 3.115 8.2065 -0.7374 10.6959
LB373-MEL-D GDSC1 3.1427 4.507 0.9085 0.425
GAK GDSC1 3.1977 4.3479 0.9856 0.1912
Hs 938.T GDSC1 3.2244 4.6077 0.9038 0.3948
WM1552C GDSC1 3.2305 6.6637 0.0538 5.1089
A-431 GDSC1 3.2333 7.3215 -0.2451 7.1154
IGR-37 GDSC1 3.2985 4.4512 0.9861 0.1598
MMAc-SF GDSC1 3.3176 4.5899 0.9451 0.2406
RPMI-7951 GDSC1 3.3182 4.8429 0.8549 0.4986
CP50-MEL-B GDSC1 3.3389 4.9403 0.8273 0.5809
IGR-1 GDSC1 3.4165 5.1119 0.795 0.6458
SK-MEL-3 GDSC1 3.4165 5.0915 0.8026 0.6181
WM793 GDSC1 3.429 5.7829 0.5389 1.8057
IPC-298 GDSC1 3.4297 4.9302 0.8666 0.4003
G-mel GDSC1 3.4424 4.9668 0.8583 0.4185
CHL-1 GDSC1 3.4513 5.5746 0.6326 1.3079
451Lu GDSC1 3.466 5.1139 0.8141 0.5464
WM115 GDSC1 3.4891 4.6953 0.97 0.1395
Mel JuSo GDSC1 3.5869 5.5385 0.7052 0.8661
MZ-MEL-7 GDSC1 3.6153 5.4721 0.7417 0.7049
SK-MEL-30 GDSC1 3.6498 11.87 -2.1337 17.3492
SH-4 GDSC1 3.6872 5.9051 0.6075 1.1946
RVH-421 GDSC1 3.7223 5.2759 0.8537 0.3058
MZ-MEL-2 GDSC1 3.9757 6.1276 0.6441 0.8157
HMV-II GDSC1 4.0415 5.9666 0.7287 0.4993
WM278 GDSC1 4.2227 6.1204 0.742 0.3837
IST-MEL1 GDSC1 4.3866 6.0319 0.8306 0.1621
DJM-1 GDSC1 4.4769 6.4444 0.7218 0.3379
SK-MEL-2 GDSC1 4.6774 5.8352 2.9699 0.5159
A-388 GDSC1 5.1697 7.841 2.3838 3.0793
COLO 829 GDSC1 5.5457 15.8773 -2.7805 15.9633
COLO 741 CTRP1 6.2825 8.4394 4.3769 4.0498
G-361 GDSC1; CTRP1 6.3787 8.1177 4.5754 1.3726
Hs 936.T CTRP1 6.873 8.1443 4.7923 0.4535
Hs 852.T CTRP1 6.935 8.368 4.7346 0.6386
Hs 944.T CTRP1 7.5403 9.0994 4.7044 0.3726
SK-MEL-28 GDSC1; CTRP1 9.2182 10.1469 7.8975 0.2503
SK-MEL-1 GDSC1; CTRP1 9.3821 10.7401 7.7364 0.5814
A-375 GDSC1; CTRP1 9.9078 11.3033 7.7477 0.2851
SK-MEL-5 GDSC1; CTRP1 9.9233 11.1582 7.8067 0.1751
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 2.812 7.5207 -0.6134 10.6623
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh30 GDSC1 -4.9793 4.906 -6.2065 71.2684
GCT GDSC1 1.3676 6.5467 -1.2296 19.3828
G-402 GDSC1 1.7613 7.0748 -1.1729 17.6051
SW872 GDSC1 2.6723 6.5591 -0.2471 8.4831
SW684 GDSC1 2.8977 4.5255 0.7978 1.0893
TE 441.T GDSC1 2.9925 4.3307 0.9136 0.5015
SW982 GDSC1 3.1348 4.6447 0.8545 0.6225
Hs 633.T GDSC1 3.1705 4.9965 0.7346 1.1091
Rh18 GDSC1 3.2945 4.9315 0.8126 0.666
SK-UT-1 GDSC1 3.7336 5.4649 0.791 0.4704
VA-ES-BJ GDSC1 3.8288 11.9809 -2.0634 16.5423
SK-LMS-1 GDSC1 3.8884 5.7885 0.7339 0.5631
MES-SA GDSC1 4.6977 15.6482 -3.2333 19.6418
EW-8 GDSC1 4.9565 12.4266 0.0757 18.1696
Rh41 GDSC1 5.4598 9.3019 1.8995 5.6718
KYM-1 GDSC1 5.4659 6.771 2.936 0.2099
MFH-ino GDSC1 5.817 7.6025 2.7734 0.4801
RD GDSC1 6.3846 8.0369 2.8282 0.1661
A-204 GDSC1 6.8464 8.9784 2.6704 0.3279
G-401 GDSC1; CTRP1 7.6871 10.1373 4.3776 0.9683
HT-1080 GDSC1; CTRP1 9.2637 11.5314 7.3232 2.4694
RKN GDSC1; CTRP1 9.7902 10.8966 7.8496 0.1438
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RF-48 GDSC1 -0.2134 5.3484 -2.0621 30.8373
23132/87 GDSC1 0.9671 6.8093 -1.7011 23.712
SNU-5 GDSC1 1.405 4.5146 -0.1825 11.8994
HSC-39 GDSC1 1.7836 5.7807 -0.5107 13.0264
IM95 GDSC1 2.0288 11.4843 -3.1588 26.5157
MKN45 GDSC1 2.2989 7.0505 -0.7486 13.0527
NCI-N87 GDSC1 2.5108 11.0348 -2.5578 22.5553
MKN1 GDSC1 3.1103 11.4342 -2.3062 19.6419
KATO III GDSC1 3.2128 10.1246 -1.5937 15.6621
NUGC-3 GDSC1 3.5381 11.0117 -1.7964 15.9048
SNU-1 GDSC1 3.7011 5.6287 0.7183 0.7322
SNU-16 GDSC1 3.7185 10.3526 -1.3584 13.0122
AGS GDSC1; CTRP1 3.7779 7.5638 3.5329 30.6622
ECC10 GDSC1 3.8912 5.7333 0.7549 0.4974
GCIY GDSC1 4.0418 5.7829 0.7936 0.3287
RERF-GC-1B GDSC1 4.0622 7.2648 0.2362 2.6328
TGBC11TKB GDSC1 4.0658 5.7839 0.802 0.3008
HGC-27 GDSC1 4.0769 5.7935 0.8027 0.2955
OCUM-1 GDSC1 4.0837 5.788 0.8071 0.2838
NUGC-4 GDSC1; CTRP1 5.3434 7.4438 4.2018 5.0449
MKN28 GDSC1 5.382 14.4066 -2.197 13.6825
Hs 746.T GDSC1 5.6842 7.4024 2.7944 0.4857
SCH GDSC1 5.8582 15.1698 -0.6177 19.0883
SH-10-TC CTRP1 6.9136 8.0711 4.834 0.2906
Fu97 GDSC1; CTRP1 7.4643 8.9554 4.7269 0.2028
MKN7 GDSC1; CTRP1 7.6649 9.6533 4.5527 0.5896
MKN74 CTRP1 7.8145 9.8202 4.5508 0.7302
SNG-M GDSC1; CTRP1 7.687 9.2022 4.7221 0.19
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
B-CPAP GDSC1 -0.0482 10.7199 -4.542 37.6921
IHH-4 GDSC1 1.0549 5.2805 -0.8624 18.1843
8505C GDSC1 1.274 8.6491 -2.359 25.8092
TT2609-C02 GDSC1 1.9213 8.1993 -1.6066 19.6587
ASH-3 GDSC1 2.2781 4.6821 0.3844 4.8931
CAL-62 GDSC1 2.7922 4.7817 0.6403 2.108
KMH-2 GDSC1 2.9251 8.739 -1.1236 13.6755
CGTH-W-1 GDSC1 3.2354 10.23 -1.6289 15.7975
TT GDSC1 3.3241 5.8354 0.4661 2.3469
WRO GDSC1 3.6696 5.1049 0.8939 0.2332
ML-1 [Human leukemia] GDSC1 3.7657 5.7951 0.6825 0.82
8305C GDSC1 3.7747 10.6162 -1.4466 13.3793
HTC-C3 GDSC1 4.0585 6.0062 0.7209 0.5133
K5 GDSC1 4.1422 5.9706 0.7649 0.3593
BHT-101 GDSC1 5.7718 14.4799 -1.9931 11.9461
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHU-011 GDSC1 -1.5198 3.2486 -2.4449 39.8975
PCI-04B GDSC1 -1.4223 5.7138 -3.4206 41.698
HSC-4 GDSC1 -1.0883 4.3543 -2.4681 37.2415
NCI-H3118 GDSC1 -0.4034 9.8662 -4.4415 38.8757
BB30-HNC GDSC1 0.3912 5.6852 -1.6571 25.9238
BICR 22 GDSC1 0.4204 6.792 -2.1762 28.4026
SAS GDSC1 0.651 7.4108 -2.2772 27.8824
KON GDSC1 1.3896 2.8315 0.6462 5.479
CAL-33 GDSC1 1.4114 5.9352 -0.8875 16.9861
PCI-06A GDSC1 1.5264 9.1333 -2.3914 25.0403
CAL-27 GDSC1 1.6905 6.1237 -0.755 15.0759
PCI-15A GDSC1 1.8617 9.0143 -2.0602 22.2883
JHU-022 GDSC1 2.1865 10.9345 -2.7598 24.4347
BICR 78 GDSC1 2.738 5.7172 0.1914 5.2061
SKN-3 GDSC1 2.8031 9.9158 -1.7859 17.8777
HO-1-N-1 GDSC1 2.8139 5.496 0.3378 4.0314
FaDu GDSC1 3.0775 5.2804 0.575 2.0694
Detroit 562 GDSC1 3.2535 5.5929 0.5321 2.0688
OSC-19 GDSC1 3.2718 5.5146 0.5733 1.8169
PE/CA-PJ15 GDSC1 3.2839 5.6506 0.5231 2.0782
PCI-38 GDSC1 3.3922 10.0691 -1.4425 14.3245
OSC-20 GDSC1 3.5429 8.8552 -0.7653 9.8274
HSC-3 GDSC1 3.5965 5.2062 0.8314 0.4203
KOSC-2 GDSC1 3.633 14.4535 -3.4055 22.8685
BICR 10 GDSC1 3.6572 5.1272 0.8818 0.2641
HO-1-u-1 GDSC1 3.7064 5.5407 0.7529 0.6068
BHY GDSC1 3.8429 5.7017 0.7477 0.545
SCC-25 GDSC1 3.8992 6.5459 0.4504 1.7188
LB771-HNC GDSC1 4.0041 5.9271 0.7285 0.5184
BICR 31 GDSC1 4.0541 6.1461 0.6686 0.6798
BB49-HNC GDSC1 4.0782 6.2175 0.652 0.7212
Ca9-22 GDSC1 4.1776 5.8514 0.8188 0.2317
SCC-15 GDSC1 4.1984 6.0661 0.7521 0.3686
SAT [Human HNSCC] GDSC1 4.3417 17.3988 -4.3336 24.2861
DOK GDSC1 4.6363 6.7037 0.6897 0.3546
HSC-2 GDSC1; CTRP1 5.9945 7.6446 4.5673 1.909
PCI-30 GDSC1 6.1915 7.8034 2.84 0.1903
SCC-9 GDSC1; CTRP1 9.7359 11.9958 7.3861 1.4148
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
T24 GDSC1 1.3661 7.6396 -1.7772 22.5799
639V GDSC1 2.4629 6.4059 -0.3164 9.5412
KU-19-19 GDSC1 2.5951 10.2379 -2.0993 20.1299
647V GDSC1 2.6656 9.2108 -1.5405 16.9171
CAL-29 GDSC1 3.0156 4.575 0.8308 0.8171
HT-1197 GDSC1 3.281 4.9923 0.7841 0.7894
BFTC-905 GDSC1 3.3065 4.7636 0.8792 0.4266
SW780 GDSC1 3.423 5.9158 0.4815 2.124
RT-112 GDSC1 3.5017 17.7509 -5.129 28.4843
5637 GDSC1; CTRP1 3.8432 14.321 -0.5296 29.8292
SW1710 GDSC1 3.8694 5.9542 0.6655 0.8104
TCCSUP GDSC1 3.9046 5.2766 0.9181 0.1307
J82 GDSC1 4.3853 6.1141 0.8024 0.2071
HT-1376 GDSC1; CTRP1 6.655 8.7645 4.443 1.6229
RT-4 GDSC1; CTRP1 7.3451 9.3606 4.53 0.7196
KMBC-2 CTRP1 7.6697 9.5279 4.6005 0.6412
UM-UC-3 GDSC1; CTRP1 7.8611 9.2216 4.776 0.0717
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NEC8 GDSC1 -0.7734 10.3515 -5.0198 41.3016
HT-3 GDSC1 -0.7053 5.8059 -2.7556 36.0723
HEY GDSC1 0.5307 6.9069 -2.134 27.7294
SW954 GDSC1 0.9545 6.1572 -1.3868 21.9604
PWR-1E GDSC1 1.9218 5.7048 -0.3666 11.523
DSH1 GDSC1 1.9568 7.4176 -1.1897 17.045
TC-YIK GDSC1 2.2006 9.6669 -2.1181 21.4559
CAL-39 GDSC1 2.5284 7.5931 -0.8475 13.0327
BPH-1 GDSC1 2.6833 9.3527 -1.5972 17.1874
HeLa GDSC1 2.7565 4.0577 0.9185 0.6648
SW756 GDSC1 2.7874 4.9623 0.5598 2.6162
SiHa GDSC1 3.0096 3.9776 1.0456 0.1276
C-4-I GDSC1 3.034 5.3929 0.5051 2.5511
OV17R GDSC1 3.1793 5.2286 0.6459 1.5437
OVMIU GDSC1 3.3588 7.182 -0.1055 5.9092
OMC-1 [Human cervical carcinoma] GDSC1 3.3737 5.766 0.5193 1.9804
HEC-1 GDSC1 3.5195 4.9386 0.8972 0.2785
PA-1 GDSC1 3.5743 5.0298 0.8854 0.286
Ca Ski GDSC1 3.6495 15.2815 -3.8 24.2263
MS751 GDSC1 3.7717 5.7207 0.7126 0.7051
SW962 GDSC1 3.7727 5.5684 0.7687 0.5176
DoTc2 4510 GDSC1 3.8679 5.7962 0.7231 0.6096
OVCA433 GDSC1 3.9198 5.9553 0.6854 0.7055
PEO1 GDSC1 4.0503 6.35 0.5915 0.9606
NT2-D1 GDSC1 4.076 5.8396 0.7864 0.333
OVCA420 GDSC1 4.091 5.8916 0.7737 0.3577
ME-180 GDSC1 4.1013 7.0893 0.3261 2.1137
NCC-IT GDSC1 4.1924 5.8092 0.8384 0.1928
KGN GDSC1 4.286 6.6296 0.5831 0.8283
UWB1.289 GDSC1 4.3714 6.4882 0.6675 0.5153
SKN GDSC1 4.4423 6.3781 0.7323 0.3267
JHOS-3 GDSC1 4.7437 6.6605 0.7425 0.2222
C-33 A GDSC1 5.0185 10.3229 1.1419 11.7351
SiSo GDSC1 5.1557 21.4856 -4.256 31.8024
ACC-OV7 GDSC1 5.2103 7.354 0.6705 0.2325
SKG-IIIa GDSC1 5.2564 6.78 2.8535 0.542
JEG-3 GDSC1 5.4809 7.2692 2.7626 0.7215
JAR GDSC1 5.6853 7.0064 2.9332 0.1546
LB831-BLC GDSC1 5.7508 7.7725 2.6849 0.6576
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Pemetrexed (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Framycetin DMF8DNE Moderate Decreased renal excretion of Pemetrexed caused by Framycetin mediated nephrotoxicity. Alcoholic liver disease [DB94] [22]
Inotersen DMJ93CT Moderate Decreased renal excretion of Pemetrexed caused by Inotersen mediated nephrotoxicity. Amyloidosis [5D00] [22]
Roflumilast DMPGHY8 Moderate Additive immunosuppressive effects by the combination of Pemetrexed and Roflumilast. Asthma [CA23] [23]
Kanamycin DM2DMPO Moderate Decreased renal excretion of Pemetrexed caused by Kanamycin mediated nephrotoxicity. Bacterial infection [1A00-1C4Z] [22]
Streptomycin DME1LQN Moderate Decreased renal excretion of Pemetrexed caused by Streptomycin mediated nephrotoxicity. Bacterial infection [1A00-1C4Z] [22]
Gentamicin DMKINJO Moderate Decreased renal excretion of Pemetrexed caused by Gentamicin mediated nephrotoxicity. Bacterial infection [1A00-1C4Z] [22]
Netilmicin DMRD1QK Moderate Decreased renal excretion of Pemetrexed caused by Netilmicin mediated nephrotoxicity. Bacterial infection [1A00-1C4Z] [22]
Tobramycin DMUI0CH Moderate Decreased renal excretion of Pemetrexed caused by Tobramycin mediated nephrotoxicity. Bacterial infection [1A00-1C4Z] [22]
Etidronic acid DM1XHYJ Moderate Decreased renal excretion of Pemetrexed caused by Etidronic acid mediated nephrotoxicity. Bone paget disease [FB85] [22]
Methoxyflurane DML0RAE Moderate Decreased renal excretion of Pemetrexed caused by Methoxyflurane mediated nephrotoxicity. Corneal disease [9A76-9A78] [22]
Pentamidine DMHZJCG Moderate Decreased renal excretion of Pemetrexed caused by Pentamidine mediated nephrotoxicity. Fungal infection [1F29-1F2F] [22]
Amphotericin B DMTAJQE Moderate Decreased renal excretion of Pemetrexed caused by Amphotericin B mediated nephrotoxicity. Fungal infection [1F29-1F2F] [22]
Teriflunomide DMQ2FKJ Major Additive immunosuppressive effects by the combination of Pemetrexed and Teriflunomide. Hyper-lipoproteinaemia [5C80] [24]
Givosiran DM5PFIJ Moderate Decreased renal excretion of Pemetrexed caused by Givosiran mediated nephrotoxicity. Inborn porphyrin/heme metabolism error [5C58] [22]
Balsalazide DM7I1T9 Moderate Decreased renal excretion of Pemetrexed caused by Balsalazide mediated nephrotoxicity. Indeterminate colitis [DD72] [22]
Denosumab DMNI0KO Moderate Additive myelosuppressive effects by the combination of Pemetrexed and Denosumab. Low bone mass disorder [FB83] [25]
Moxetumomab pasudotox DMN63DZ Moderate Decreased renal excretion of Pemetrexed caused by Moxetumomab pasudotox mediated nephrotoxicity. Mature B-cell leukaemia [2A82] [22]
Exjade DMHPRWG Moderate Decreased renal excretion of Pemetrexed caused by Exjade mediated nephrotoxicity. Mineral absorption/transport disorder [5C64] [22]
Gallium nitrate DMF9O6B Moderate Decreased renal excretion of Pemetrexed caused by Gallium nitrate mediated nephrotoxicity. Mineral excesses [5B91] [22]
Thalidomide DM70BU5 Major Additive thrombogenic effects by the combination of Pemetrexed and Thalidomide. Multiple myeloma [2A83] [26]
Tecfidera DM2OVDT Moderate Additive immunosuppressive effects by the combination of Pemetrexed and Tecfidera. Multiple sclerosis [8A40] [27]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Pemetrexed and Siponimod. Multiple sclerosis [8A40] [28]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Pemetrexed and Fingolimod. Multiple sclerosis [8A40] [29]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Pemetrexed and Ocrelizumab. Multiple sclerosis [8A40] [30]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Pemetrexed and Ozanimod. Multiple sclerosis [8A40] [23]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive myelosuppressive effects by the combination of Pemetrexed and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [31]
Temsirolimus DMS104F Moderate Decreased renal excretion of Pemetrexed caused by Temsirolimus mediated nephrotoxicity. Renal cell carcinoma [2C90] [22]
Colistimethate DMZ9BMU Moderate Decreased renal excretion of Pemetrexed caused by Colistimethate mediated nephrotoxicity. Respiratory infection [CA07-CA4Z] [22]
Canakinumab DM8HLO5 Moderate Additive immunosuppressive effects by the combination of Pemetrexed and Canakinumab. Rheumatoid arthritis [FA20] [32]
Rilonacept DMGLUQS Moderate Additive immunosuppressive effects by the combination of Pemetrexed and Rilonacept. Rheumatoid arthritis [FA20] [32]
Golimumab DMHZV7X Major Additive immunosuppressive effects by the combination of Pemetrexed and Golimumab. Rheumatoid arthritis [FA20] [33]
Sulfasalazine DMICA9H Moderate Decreased renal excretion of Pemetrexed caused by Sulfasalazine mediated nephrotoxicity. Rheumatoid arthritis [FA20] [22]
Leflunomide DMR8ONJ Major Additive immunosuppressive effects by the combination of Pemetrexed and Leflunomide. Rheumatoid arthritis [FA20] [24]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Pemetrexed when combined with Anthrax vaccine. Sepsis [1G40-1G41] [34]
Telavancin DM58VQX Moderate Decreased renal excretion of Pemetrexed caused by Telavancin mediated nephrotoxicity. Staphylococcal/streptococcal disease [1B5Y] [22]
Sirolimus DMGW1ID Moderate Decreased renal excretion of Pemetrexed caused by Sirolimus mediated nephrotoxicity. Transplant rejection [NE84] [22]
Azathioprine DMMZSXQ Moderate Additive immunosuppressive effects by the combination of Pemetrexed and Azathioprine. Transplant rejection [NE84] [28]
Tacrolimus DMZ7XNQ Moderate Decreased renal excretion of Pemetrexed caused by Tacrolimus mediated nephrotoxicity. Transplant rejection [NE84] [22]
Olsalazine DMZW9HA Moderate Decreased renal excretion of Pemetrexed caused by Olsalazine mediated nephrotoxicity. Ulcerative colitis [DD71] [22]
Plazomicin DMKMBES Moderate Decreased renal excretion of Pemetrexed caused by Plazomicin mediated nephrotoxicity. Urinary tract infection [GC08] [22]
Ganciclovir DM1MBYQ Moderate Additive myelosuppressive effects by the combination of Pemetrexed and Ganciclovir. Virus infection [1A24-1D9Z] [28]
Valganciclovir DMS2IUH Moderate Additive myelosuppressive effects by the combination of Pemetrexed and Valganciclovir. Virus infection [1A24-1D9Z] [28]
⏷ Show the Full List of 42 DDI Information of This Drug

References

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