Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT5POTG)

• DTT Name: Glutamate receptor ionotropic NMDA 2D (GluN2D) DTT Info
• Gene Name: GRIN2D

Molecule-Related Drug & Molecule List

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[1]

18 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(RS)-(tetrazol-5-yl)glycine	DMYZCRF	Discovery agent	N.A.	Investigative	[1]
2-Methylamino-succinic acid(NMDA)	DMKP6BM	Discovery agent	N.A.	Investigative	[1]
CGP61594	DM8KFZH	Discovery agent	N.A.	Investigative	[1]
d-AP5	DMY5OTN	Discovery agent	N.A.	Investigative	[1]
D-aspartic acid	DM7Z892	Discovery agent	N.A.	Investigative	[1]
d-CCPene	DM36D0F	Discovery agent	N.A.	Investigative	[1]
DQP-1105	DMQLJ3Y	Discovery agent	N.A.	Investigative	[2]
homoquinolinic acid	DMBW5DU	Discovery agent	N.A.	Investigative	[1]
L-aspartic acid	DMWGPO6	Hypokalemia	5C77	Investigative	[1]
LY233053	DMC82DA	Discovery agent	N.A.	Investigative	[1]
N1-dansyl-spermine	DM76CLF	Discovery agent	N.A.	Investigative	[1]
QNZ 46	DM01RZX	Discovery agent	N.A.	Investigative	[3]
UBP141	DM6IG5J	Discovery agent	N.A.	Investigative	[4]
[3H]CGP39653	DMITR7A	Discovery agent	N.A.	Investigative	[1]
[3H]CGS19755	DM7H3JN	Discovery agent	N.A.	Investigative	[1]
[3H]CPP	DMR5UBF	Discovery agent	N.A.	Investigative	[1]
[3H]dizocilpine	DMEC2PF	Discovery agent	N.A.	Investigative	[1]
[3H]MDL105519	DMPKGHB	Discovery agent	N.A.	Investigative	[1]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459).
• [2] Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol Pharmacol. 2011 Nov;80(5):782-95.
• [3] Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci. 2011 Mar 9;31(10):3650-61.
• [4] Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37.