Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT731LW)

• DTT Name: Colony stimulating factor-1 receptor (CSF-1R) DTT Info
• Gene Name: CSF1R

Molecule-Related Drug & Molecule List

8 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARRY-382	DM0VGDC	Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]
JNJ-40346527	DM219SF	Hodgkin lymphoma	2B30	Phase 2	[2]
MCS-110	DM0CL4I	Bone metastases	2D50	Phase 2	[3]
PD-360324	DM6F5EV	Rheumatoid arthritis	FA20	Phase 2	[4]
RG7155	DM8JMNL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[5]
FPA-008	DM3ZN6Y	Autoimmune diabetes	5A10	Phase 1/2	[6]
AMG 820	DMB6Q19	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
IMC-CS4	DMUYN26	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]

References

• [1] Company report (Array)
• [2] An Open-Label, Multicenter, Phase I/II Study of JNJ-40346527, a CSF-1R Inhibitor, in Patients with Relapsed or Refractory Hodgkin Lymphoma. Clin Cancer Res. 2015 Apr 15;21(8):1843-50.
• [3] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [4] Monoclonal antibody against macrophage colony-stimulating factor suppresses circulating monocytes and tissue macrophage function but does not alter cell infiltration/activation in cutaneous lesions or clinical outcomes in patients with cutaneous lupus erythematosus.Clin Exp Immunol.2016 Feb;183(2):258-70.
• [5] Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell. 2014 Jun 16;25(6):846-59.
• [6] Company report (Five Prime Therapeutics)