Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT7MRDV)

• DTT Name: Macrophage colony-stimulating factor 1 receptor (CSF1R) DTT Info
• Gene Name: CSF1R

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pexidartinib	DMS2J0Z	Tenosynovial giant cell tumour	2F7B	Approved	[1]

13 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfatinib	DMPOTM4	Neuroendocrine cancer	2B72.1	Phase 3	[2]
AMB-05X	DM958C5	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[3]
ARRY-382	DM0VGDC	Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
BLZ-945	DMG1LVA	Amyotrophic lateral sclerosis	8B60.0	Phase 2	[2]
Cabiralizumab	DMGE058	Pancreatic cancer	2C10	Phase 2	[4]
DCC-3014	DMHW289	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]
FPA-008	DM3ZN6Y	Autoimmune diabetes	5A10	Phase 1/2	[5]
ABSK021	DMA4WEO	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
Axatilamab	DMFBMU7	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
EI1071	DMXAUB7	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
PLX7486	DM0IVGU	Pancreatic cancer	2C10	Phase 1	[2]
SNDX-6352	DM8ZROW	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
TPX-0022	DMC2IJN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]

6 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID28270010-Compound-Figure24-a	DMNTQL5	N. A.	N. A.	Patented	[10]
Pyridine derivative 18	DMBZMYT	N. A.	N. A.	Patented	[11]
Pyridine derivative 19	DMXYT40	N. A.	N. A.	Patented	[11]
Pyridine derivative 20	DMAOF0W	N. A.	N. A.	Patented	[11]
Pyridine derivative 21	DMF3907	N. A.	N. A.	Patented	[11]
Pyridine derivative 22	DMSIERF	N. A.	N. A.	Patented	[11]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Clinical pipeline report, company report or official report of AmMax Bio
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Clinical pipeline report, company report or official report of Abbisko Therapeutics.
• [7] Clinical pipeline report, company report or official report of Syndax Pharmaceuticals.
• [8] Clinical pipeline report, company report or official report of Elixiron Immunotherapeutics.
• [9] Clinical pipeline report, company report or official report of Turning Point Therapeutics.
• [10] Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751.
• [11] RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99.