Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT7WD0H)

DTT Name	Epidermal growth factor-like protein 7 (EGFL7) DTT Info
Gene Name	EGFL7

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Discontinued Drug(s)

Clinical Trial Drug(s)

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2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MEGF0444A	DM2C1YN	Metastatic colorectal cancer	2B91	Phase 2	[1]
Anti-EGFL7	DM0ZDJ5	Non-small-cell lung cancer	2C25.Y	Phase 1	[2]
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1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RG7414	DMCQRS2	Colorectal cancer	2B91.Z	Discontinued in Phase 2	[3]
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Molecule Interaction Atlas

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References

1	A first-in-human phase Ia open-label dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of the humanized monoclonal antibody (huMAb) anti-EGFL7 (MEGF0444A) administered intravenously in patients with advanced solid tumors. J Clin Oncol (Meeting Abstracts) May 2011 vol.29 no.15_suppl 2614.
2	Clinical pipeline report, company report or official report of Genentech (2009).
3	Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy. J Clin Invest. 2013 September 3; 123(9): 3997-4009.