Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT7WUAV)

• DTT Name: Protein-tyrosine phosphatase SHP-2 (PTPN11) DTT Info
• Gene Name: PTPN11

Molecule-Related Drug & Molecule List

9 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JAB-3312	DMNMV0D	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
A380	DMXOZDP	Aggressive cancer	2A00-2F9Z	Phase 1	[2]
BBP-398	DM572ZL	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
JAB-3068	DMSGEU6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
PF-07284892	DMQ6F8X	Aggressive cancer	2A00-2F9Z	Phase 1	[4]
RG6433	DMZM06U	Aggressive cancer	2A00-2F9Z	Phase 1	[5]
RLY-1971	DMUT4YZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
SAR442720	DMTAOPC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
TNO155	DMZ60X4	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]

1 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NSC-87877	DMEYKXL	Discovery agent	N.A.	Patented	[9]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dodecane-Trimethylamine	DMUPMCZ	Discovery agent	N.A.	Investigative	[10]

References

• [1] Clinical pipeline report, company report or official report of AbbVie.
• [2] Clinical pipeline report, company report or official report of Klus Pharma
• [3] ClinicalTrials.gov (NCT04528836) First-in-Human Study of the SHP2 Inhibitor BBP-398 in Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
• [4] SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy. Cancer Discov. 2023 Aug 4;13(8):1789-1801.
• [5] Clinical pipeline report, company report or official report of Roche
• [6] Clinical pipeline report, company report or official report of Relay Therapeutics.
• [7] Clinical pipeline report, company report or official report of Revolution Medicines.
• [8] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [9] Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem. 2008 Aug 28;51(16):4948-56.
• [10] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.