General Information of DTT (ID: TT85JMW)

DTT Name Bacterial Penicillin binding protein 3 (Bact mrcA) DTT Info
Gene Name Bact mrcA

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
7 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aztreonam DMDNJHG Bacterial infection 1A00-1C4Z Approved [1]
Cefmenoxime DMPLY7B Bacterial infection 1A00-1C4Z Approved [2]
Cefmetazole DM42W1B Bacterial infection 1A00-1C4Z Approved [3]
Cefotiam DMF5HU6 Respiratory tract infection CA45 Approved [4]
Latamoxef DMANL0D Bacterial infection 1A00-1C4Z Approved [3]
Mezlocillin DMY5JEP Acute gonococcal cervicitis Approved [5]
Moxalactam Disodium DMYKUNR Bacterial infection 1A00-1C4Z Approved [6]
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⏷ Show the Full List of 7 Approved Drug(s)
2 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [7]
LYS228 DM23Y6K Urinary tract infection GC08 Phase 2 [8]
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3 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acylureido penicillin mezlocillin DM4CYKE Discovery agent N.A. Investigative [9]
Cephalosporin C DMYW3ZG Discovery agent N.A. Investigative [10]
PCNOTAXIME GROUP DMGS6YH Discovery agent N.A. Investigative [11]
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Molecule Interaction Atlas

References

1 Penicillin-binding protein PBP2 of Escherichia coli localizes preferentially in the lateral wall and at mid-cell in comparison with the old cell pole. Mol Microbiol. 2003 Jan;47(2):539-47.
2 In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity. Antimicrob Agents Chemother. 1988 May;32(5):693-701.
3 Clinical relevance of antibiotic-induced endotoxin release in patients undergoing hepatic resection. World J Surg. 1999 Jan;23(1):75-9.
4 Genetic analyses of beta-lactamase negative ampicillin-resistant strains of Haemophilus influenzae isolated in Okinawa, Japan. Jpn J Infect Dis. 2006 Feb;59(1):36-41.
5 Bactericidal effect of piperacillin alone and combined. Presse Med. 1986 Dec 20;15(46):2297-302.
6 Moxalactam (6059-S), a new 1-oxa-beta-lactam: binding affinity for penicillin-binding proteins of Escherichia coli K-12.
7 Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother. 2001 Jun;45(6):1693-9.
8 Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae. Antimicrob Agents Chemother. 2018 Sep 24;62(10):e01200-18.
9 Microbiology, pharmacology, and clinical use of mezlocillin sodium. Pharmacotherapy. 1982 Nov-Dec;2(6):300-12.
10 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
11 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.