Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTBFROQ)

DTT Name S-adenosylmethionine decarboxylase proenzyme (AMD1) DTT Info
Gene Name AMD1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tromethamine DMOBLGK Acidosis 5C73 Approved [1]
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1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ORG 34517/34850 DMR3P98 Mood disorder 6A60-6E23 Phase 2 [2]
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3 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Putrescine DMWE6V1 Burn and burn infection ND90-NE2Z Discontinued in Phase 2 [1]
CGP-40215A DM69YWS Pneumocystis pneumonia CA40.20 Terminated [3]
MGBG DM9GOT6 Head and neck cancer 2D42 Terminated [2]
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7 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine DMT6D5V Discovery agent N.A. Investigative [4]
5'-Deoxy-5'-(N,N-dimethylamino)-8-methyladenosine DMOHSY0 Discovery agent N.A. Investigative [5]
5'-Deoxy-5'-(N,N-dimethylamino)adenosine DMF7JPO Discovery agent N.A. Investigative [5]
5'-Deoxy-5'-dimethylsulfonioadenosine chloride DM1NAMK Discovery agent N.A. Investigative [5]
5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine DM6HGUL Discovery agent N.A. Investigative [4]
Hydroxyalanine DM5HWZY Discovery agent N.A. Investigative [6]
[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine DM3WDOY Discovery agent N.A. Investigative [5]
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⏷ Show the Full List of 7 Investigative Drug(s)
Molecule Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601.
3 Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70.
4 S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.
5 New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407.
6 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.