Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTBYWP2)

• DTT Name: TYK2 tyrosine kinase (TYK2) DTT Info
• Gene Name: TYK2

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deucravacitinib	DMAR1YS	Plaque psoriasis	EA90.0	Approved	[1]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NDI-034858	DM2FJE7	Psoriatic arthritis	FA21	Phase 2	[2]
PF-06700841	DMMGSFV	Asthma	CA23	Phase 2	[1]
PF-06826647	DM5H8V1	Plaque psoriasis	EA90.0	Phase 2	[1]

35 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminooxazole carboxamide derivative 1	DMDHGPN	N. A.	N. A.	Patented	[3]
Aminopyridine derivative 1	DMYE1A7	N. A.	N. A.	Patented	[3]
Aminopyrimidine derivative 5	DM5OZPV	N. A.	N. A.	Patented	[3]
Aminotriazolopyridine derivative 1	DMW2LZ0	N. A.	N. A.	Patented	[4]
Benzimidazole derivative 7	DMDK4RI	N. A.	N. A.	Patented	[4]
Bis-aminopyrimidine derivative 1	DMQL34C	N. A.	N. A.	Patented	[4]
Bis-aminopyrimidine derivative 2	DMJXNO1	N. A.	N. A.	Patented	[4]
Bis-aminopyrimidine derivative 3	DMUNSYX	N. A.	N. A.	Patented	[4]
Bis-aminopyrimidine derivative 4	DMO1ZIG	N. A.	N. A.	Patented	[4]
Bis-aminopyrimidine derivative 5	DMWXLK1	N. A.	N. A.	Patented	[4]
Imidazopyridine derivative 3	DMJCSL3	N. A.	N. A.	Patented	[3]
Imidazo[4,5-c]pyridine derivative 1	DM4KBZQ	N. A.	N. A.	Patented	[4]
Imidazo[4,5-c]pyridine derivative 2	DMFDRJT	N. A.	N. A.	Patented	[4]
N-methylmethanesulfonamide derivative 1	DMIVK7D	N. A.	N. A.	Patented	[3]
PMID27774822-Compound-Figure11Example5	DMAHFXV	N. A.	N. A.	Patented	[3]
PMID27774822-Compound-Figure3CompoundI-165	DMOENP4	N. A.	N. A.	Patented	[3]
PMID27774822-Compound-Figure9Example15	DMSHIT2	N. A.	N. A.	Patented	[3]
PMID27774824-Compound-Figure11Example1up	DMH1W8F	N. A.	N. A.	Patented	[4]
PMID27774824-Compound-Figure3Example18	DMYZ6XQ	N. A.	N. A.	Patented	[4]
PMID27774824-Compound-Figure6Example12	DM1CM7S	N. A.	N. A.	Patented	[4]
PMID27774824-Compound-Figure9Example2down	DMXAV42	N. A.	N. A.	Patented	[4]
PMID27774824-Compound-Figure9Example2up	DME3TMS	N. A.	N. A.	Patented	[4]
Pyrazolopyridine derivative 3	DM2VQ4P	N. A.	N. A.	Patented	[3]
Pyrazolopyridine derivative 5	DMTZCLG	N. A.	N. A.	Patented	[3]
Pyrazolo[4,3-c]pyridine derivative 2	DMCDFLQ	N. A.	N. A.	Patented	[4]
Pyrrole derivative 7	DMZCERW	N. A.	N. A.	Patented	[3]
Pyrrolo-pyridone derivative 3	DMUIK3W	N. A.	N. A.	Patented	[3]
Pyrrolo[2,3-d]pyrimidine derivative 6	DM3D1L6	N. A.	N. A.	Patented	[3]
Pyrrolo[2,3-d]pyrimidine derivative 7	DM30Y8M	N. A.	N. A.	Patented	[3]
Pyrrolo[2,3-d]pyrimidine derivative 8	DMAW6KU	N. A.	N. A.	Patented	[3]
Thiazolopyridine derivative 1	DMAFE5R	N. A.	N. A.	Patented	[3]
Tricyclic compound 11	DMJAZ7D	N. A.	N. A.	Patented	[3]
Tricyclic heterocycle derivative 1	DMXLJH4	N. A.	N. A.	Patented	[3]
Tricyclic heterocycle derivative 5	DMG1ESV	N. A.	N. A.	Patented	[3]
Tricyclic pyrrolopyridine compound 1	DMFIXW4	N. A.	N. A.	Patented	[3]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CMP-6	DM241YW	Discovery agent	N.A.	Investigative	[5]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Clinical pipeline report, company report or official report of Nimbus Therapeutics
• [3] Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161.
• [4] Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143.
• [5] A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.