Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTFLN4T)

• DTT Name: Mitochondrial aldehyde dehydrogenase (ALDH2) DTT Info
• Gene Name: ALDH2

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALD-401	DM2U530	Cerebrovascular ischaemia	8B1Z	Phase 2	[1]
ANS-6637	DM39QWN	Substance use disorder	6C4Z	Phase 1	[2]
FP-045	DMV9FTH	Cardiovascular disease	BA00-BE2Z	Phase 1	[3]
GS-6637	DMXG3T1	Substance use disorder	6C4Z	Phase 1	[4]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daidzin	DMFCMPS	N. A.	N. A.	Terminated	[5]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[5]
CVT-10216	DMDH6PJ	Alcohol dependence	6C40.2	Investigative	[6]
ISOFORMONENTIN	DM5CMA8	Discovery agent	N.A.	Investigative	[7]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[5]
prunetin	DMPD41Q	Discovery agent	N.A.	Investigative	[7]

References

• [1] A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo. Clin Cancer Res. 2011 Dec 1;17(23):7265-72.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Clinical pipeline report, company report or official report of Gilead.
• [5] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2595).
• [7] Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. J Med Chem. 2008 Aug 14;51(15):4482-7.