Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTK1N5G)

• DTT Name: MAPK/ERK kinase kinase 2 (MAP3K2) DTT Info
• Gene Name: MAP3K2

Molecule-Related Drug & Molecule List

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[1]
LLZ16407	DM783BP	Discovery agent	N.A.	Investigative	[1]
Ro092210	DM2DXHO	Discovery agent	N.A.	Investigative	[1]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[1]
URMC-099	DMCJXWK	Discovery agent	N.A.	Investigative	[2]

References

• [1] Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.
• [2] Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48.