Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTMJX4U)

• DTT Name: Herpes simplex virus Ribonucleoside-diphosphate reductase (HSV RIR1) DTT Info
• Gene Name: HSV RIR1

Molecule-Related Drug & Molecule List

4 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BILD-1263	DMUOPBF	Herpes simplex virus infection	1F00	Terminated	[1]
BILD-1351	DMR01WE	Herpes simplex virus infection	1F00	Terminated	[2]
BILD-1357	DMZMUG2	Herpes simplex virus infection	1F00	Terminated	[3]
BILD-733	DMAU5WL	Herpes simplex virus infection	1F00	Terminated	[4]

References

• [1] Evaluation of a peptidomimetic ribonucleotide reductase inhibitor with a murine model of herpes simplex virus type 1 ocular disease. Antimicrob Agents Chemother. 1996 May;40(5):1078-84.
• [2] The antiviral activity of the ribonucleotide reductase inhibitor BILD 1351 SE in combination with acyclovir against HSV type-1 in cell culture. Antiviral Res. 1998 Jul;39(1):35-46.
• [3] Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity. J Med Chem. 1996 Oct 11;39(21):4173-80.
• [4] Resistance of herpes simplex virus type 1 to peptidomimetic ribonucleotide reductase inhibitors: selection and characterization of mutant isolates. J Virol. 1996 Feb;70(2):787-93.