Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTO8QRU)

• DTT Name: Group IIA phospholipase A2 (GIIA sPLA2) DTT Info
• Gene Name: PLA2G2A

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KH064	DMR1NYF	Breast cancer	2C60-2C65	Clinical trial	[1]

15 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,4-Butanediol	DMVHKZT	Discovery agent	N.A.	Investigative	[2]
2-(4-phenoxyphenoxy)ethanamine	DM7TBUJ	Discovery agent	N.A.	Investigative	[3]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[4]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[5]
BOLINAQUINONE	DMVB6UG	Discovery agent	N.A.	Investigative	[6]
CACOSPONGIONOLIDE	DMIPJUS	Discovery agent	N.A.	Investigative	[7]
CACOSPONGIONOLIDE B	DMCSXNW	Discovery agent	N.A.	Investigative	[7]
Cacospongionolide E	DM2DYAV	Discovery agent	N.A.	Investigative	[7]
DIDODECANOYLPHLOROGLUCINOL	DM2FLRQ	Discovery agent	N.A.	Investigative	[8]
DYSIDINE	DMNYQL9	Discovery agent	N.A.	Investigative	[6]
Elaidoylamide	DMP8VDT	Discovery agent	N.A.	Investigative	[5]
Lauric Acid	DM9C8KQ	Discovery agent	N.A.	Investigative	[5]
LUFFARIELLOLIDE	DMYRCHV	Discovery agent	N.A.	Investigative	[9]
N-Tridecanoic Acid	DMNZ37C	Discovery agent	N.A.	Investigative	[4]
Ochnaflavone	DMGVDR6	Discovery agent	N.A.	Investigative	[10]

References

• [1] D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity. Chembiochem. 2003 Mar 3;4(2-3):181-5.
• [2] Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivo. Eur J Pharmacol. 2003 Jul 25;473(2-3):149-52.
• [3] Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem. 2008 Dec 25;51(24):7882-8.
• [4] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [5] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [6] New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte... J Nat Prod. 2001 May;64(5):612-5.
• [7] A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5.
• [8] Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5415-9.
• [9] Phospholipase A2 inhibitors from marine organisms. J Nat Prod. 1992 Dec;55(12):1701-17.
• [10] Synthesis of phospholipase A2 inhibitory biflavonoids. Bioorg Med Chem Lett. 2006 May 1;16(9):2373-5.