Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTOHFIY)

DTT Name	Sphingosine kinase 1 (SPHK1) DTT Info
Gene Name	SPHK1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Discontinued Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenoxodiol	DMBUJVX	Ovarian cancer	2C73	Phase 1/2	[1]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[2]
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11 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylbenzenesulfonamide derivative 1	DMUNME2	N. A.	N. A.	Patented	[3]
PMID27539678-Compound-10	DM61SR0	N. A.	N. A.	Patented	[3]
PMID27539678-Compound-11	DMIKAJC	N. A.	N. A.	Patented	[3]
PMID27539678-Compound-12	DMNIKTA	N. A.	N. A.	Patented	[3]
PMID27539678-Compound-13	DM1J2V8	N. A.	N. A.	Patented	[3]
PMID27539678-Compound-14	DMZ02LA	N. A.	N. A.	Patented	[3]
PMID27539678-Compound-16	DMMDJH8	N. A.	N. A.	Patented	[3]
PMID27539678-Compound-17	DMVG7A5	N. A.	N. A.	Patented	[3]
PMID27539678-Compound-6	DMBKNDE	N. A.	N. A.	Patented	[3]
PMID27539678-Compound-7	DMQAC4K	N. A.	N. A.	Patented	[3]
PMID27539678-Compound-9	DM0Y5NU	N. A.	N. A.	Patented	[3]
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⏷ Show the Full List of 11 Patented Agent(s)

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
B-5354a	DM8I5UF	Arteriosclerosis	BD40	Terminated	[4]
F-12509A	DM3786U	Arteriosclerosis	BD40	Terminated	[5]
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3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-543	DMC4UHD	Discovery agent	N.A.	Investigative	[6]
SK1-I	DMMYX7C	Discovery agent	N.A.	Investigative	[7]
VPC-94075	DM20AJ4	Vascular disease	BE2Z	Investigative	[8]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
2	Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.Oncotarget. 2016 Dec 6;7(49):80586-80598.
3	Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416.
4	Characterization of B-5354c, a new sphingosine kinase inhibitor, produced by a marine bacterium. J Antibiot (Tokyo). 2000 Aug;53(8):759-64.
5	F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete. J Antibiot (Tokyo). 2000 May;53(5):459-66.
6	Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88.
7	A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood. 2008 Aug 15;112(4):1382-91.
8	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2204).