Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTQ8KVI)

• DTT Name: Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DTT Info
• Gene Name: Stap-coc pbp2

Molecule-Related Drug & Molecule List

17 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[1]
Clomocycline	DM0ZRMQ	Bacterial infection	1A00-1C4Z	Approved	[2]
Demeclocycline	DMZEPFJ	Acne vulgaris	ED80	Approved	[3]
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[4]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[5]
Lymecycline	DMOMLHJ	Bacterial infection	1A00-1C4Z	Approved	[6]
Meclocycline	DMSFQ8I	Bacterial infection	1A00-1C4Z	Approved	[3]
Methacycline	DMAY96V	Bacterial infection	1A00-1C4Z	Approved	[7]
Minocycline	DMVN5OH	Acne vulgaris	ED80	Approved	[8]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[9]
Oxytetracycline	DMOVH1M	Actinomycosis		Approved	[3]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[10]
Rolitetracycline	DMBR5Q7	Acne vulgaris	ED80	Approved	[11]
Spectinomycin	DM0MQ35	Acute gonococcal cervicitis		Approved	[12]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[12]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[13]
Tigecycline	DMLE7IO	Skin infection	1F28-1G0Z	Approved	[14]

References

• [1] Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9.
• [2] Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5.
• [3] Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13.
• [4] Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9.
• [5] SsrA-mediated protein tagging in the presence of miscoding drugs and its physiological role in Escherichia coli. Genes Cells. 2002 Jul;7(7):629-38.
• [6] Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
• [7] Tetracyclines and pulmonary inflammation. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):232-6.
• [8] Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66.
• [9] Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea. Antimicrob Agents Chemother. 1982 Aug;22(2):231-6.
• [10] Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30.
• [11] Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection fo... J Chromatogr A. 2008 Jun 27;1195(1-2):107-16.
• [12] Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8.
• [13] The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88.
• [14] Tigecycline: first of a new class of antimicrobial agents. Pharmacotherapy. 2006 Aug;26(8):1099-110.