Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTRPDBG)

• DTT Name: Inhibitor of nuclear factor kappa-B kinase (IKK) DTT Info
• Gene Name: IKK

Molecule-Related Drug & Molecule List

4 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrothieno [2,3-e]indazole derivative 1	DMUJ3XK	N. A.	N. A.	Patented	[1]
Dihydrothieno [2,3-e]indazole derivative 2	DM0D3HU	N. A.	N. A.	Patented	[1]
Dihydrothieno [2,3-e]indazole derivative 3	DM85VQR	N. A.	N. A.	Patented	[1]
Dihydrothieno [2,3-e]indazole derivative 4	DMR4LPO	N. A.	N. A.	Patented	[1]

10 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[2]
5-Bromo-6-methoxy-9H-beta-carboline	DM157OQ	Discovery agent	N.A.	Investigative	[3]
Arsenite	DMBCO4Q	Discovery agent	N.A.	Investigative	[4]
BMS-345541	DM7D519	Arthritis	FA20	Investigative	[5]
MLN-120B	DMYKNSP	Discovery agent	N.A.	Investigative	[6]
MRT67307	DMYRCHG	Discovery agent	N.A.	Investigative	[7]
PMID23099093C17d	DMWS7O9	Discovery agent	N.A.	Investigative	[8]
PS-1145	DMVUMWZ	Multiple myeloma	2A83	Investigative	[9]
S1627	DMD4KLQ	Discovery agent	N.A.	Investigative	[10]
TPCA-1	DMA14PR	Discovery agent	N.A.	Investigative	[11]

References

• [1] Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34.
• [2] IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J Biol Chem. 2001 May 25;276(21):18223-8.
• [3] Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2419-22.
• [4] Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17;275(46):36062-6.
• [5] A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum. 2003 Sep;48(9):2652-9.
• [6] A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like syno... J Pharmacol Exp Ther. 2006 Jun;317(3):989-1001.
• [7] Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.
• [8] Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73.
• [9] Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
• [10] Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. J Neurosci. 2004 Feb 18;24(7):1637-45.
• [11] Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbo... J Pharmacol Exp Ther. 2005 Jan;312(1):373-81.