Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTX4GLS)

• DTT Name: Mammalian target of rapamycin complex 1 (mTORC1) DTT Info
• Gene Name: MTOR-RPTORA-MLST8-KT1S1-DEPTOR

Molecule-Related Drug & Molecule List

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RBT-101	DMDZW8K	Respiratory tract infection	CA45	Phase 3	[1]
AZD2014	DMOEARH	Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
ME-344	DM6JN19	Breast cancer	2C60-2C65	Phase 1/2	[2]
NV-5138	DMLKS7W	Major depressive disorder	6A70.3	Phase 1	[3]
Palomid-529	DM428Y3	Alzheimer disease	8A20	Phase 1	[4]
VS-5584	DMMO3G5	Malignant mesothelioma	2C26.0	Phase 1	[5]

References

• [1] Constrained peptides' time to shine. Nat Rev Drug Discov. 2018 Jul 30;17(8):531-533.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554.
• [4] Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the blood-brain barrier without restriction by ABCB1 and ABCG2. Int J Cancer. 2013 Sep 1;133(5):1222-33.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)