Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTYJOLE)

• DTT Name: MERS-CoV papain-like proteinase (PL-PRO) DTT Info
• Gene Name: MERS-CoV rep

Molecule-Related Drug & Molecule List

4 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[1]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[2]
Mycophenolic acid	DMRBMAU	Crohn disease	DD70	Approved	[3]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[2]

1 Preclinical Drugs Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID30940566-compound-6	DMXCKL9	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[4]

References

• [1] Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150.
• [2] Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Antiviral Res. 2015 Mar;115:9-16.
• [3] SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016 Aug;14(8):523-34.
• [4] Identification and Design of Novel Small Molecule Inhibitors Against MERS-CoV Papain-Like Protease via High-Throughput Screening and Molecular Modeling Bioorg Med Chem. 2019 May 15;27(10):1981-1989.