Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZHA0O)

• DTT Name: Carbonic anhydrase IV (CA-IV) DTT Info
• Gene Name: CA4

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[1]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[2]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[3]

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[4]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[5]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[4]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[6]
Sodium pyruvate	DMST6A3	Asthma	CA23	Phase 1/2	[7]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[8]

1 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[5]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[9]

60 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-(3,4-dichlorophenyl)-3-hydroxyurea	DMVOJ7K	Discovery agent	N.A.	Investigative	[10]
2,4-Disulfamyltrifluoromethylaniline	DM2AW0Z	Discovery agent	N.A.	Investigative	[3]
2-oxo-2H-chromene-3-carboxylic acid	DMFN769	Discovery agent	N.A.	Investigative	[11]
2-Propyl-pentanoic acid 4-sulfamoyl-benzyl ester	DM1L7PN	Discovery agent	N.A.	Investigative	[12]
2-Propyl-pentanoic acid 4-sulfamoyl-benzylamide	DMVWUME	Discovery agent	N.A.	Investigative	[12]
3-Amino-benzenesulfonamide	DME0TNA	Discovery agent	N.A.	Investigative	[3]
4-(2-AMINOETHYL)BENZENESULFONAMIDE	DMEK6WX	Discovery agent	N.A.	Investigative	[3]
4-Amino-3-bromo-benzenesulfonamide	DMVUCZK	Discovery agent	N.A.	Investigative	[3]
4-Amino-3-chloro-benzenesulfonamide	DMERTQ4	Discovery agent	N.A.	Investigative	[3]
4-Amino-3-fluoro-benzenesulfonamide	DMIQ3VR	Discovery agent	N.A.	Investigative	[3]
4-Amino-3-iodo-benzenesulfonamide	DMCOYHR	Discovery agent	N.A.	Investigative	[3]
4-Hydrazino-benzenesulfonamide	DM49B18	Discovery agent	N.A.	Investigative	[3]
6-(aminomethyl)-2H-chromen-2-one	DMJU9TG	Discovery agent	N.A.	Investigative	[11]
6-(hydroxymethyl)-2H-chromen-2-one	DM5TOX2	Discovery agent	N.A.	Investigative	[11]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid	DMZ6HQL	Discovery agent	N.A.	Investigative	[11]
7-(benzyloxy)-2H-chromen-2-one	DMTKFPW	Discovery agent	N.A.	Investigative	[11]
Aminocarbonyl dihydrogen phosphate	DMCLVOZ	Discovery agent	N.A.	Investigative	[13]
BENZOLAMIDE	DME5QPX	Discovery agent	N.A.	Investigative	[14]
Carbamoyl phosphate disodium	DMZYK1W	Discovery agent	N.A.	Investigative	[15]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[4]
CATECHOL	DML0YEK	Discovery agent	N.A.	Investigative	[5]
CL-5343	DM9AFZ3	Solid tumour/cancer	2A00-2F9Z	Investigative	[16]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[11]
Decane-1,10-diyl disulfamate	DM1ESVR	Discovery agent	N.A.	Investigative	[17]
Decyl sulfamate	DMIERWO	Discovery agent	N.A.	Investigative	[17]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[5]
Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate	DMWIB0V	Discovery agent	N.A.	Investigative	[11]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[5]
HERNIARIN	DM9UASM	Discovery agent	N.A.	Investigative	[11]
Hexane-1,6-diamine	DMSHF0K	Discovery agent	N.A.	Investigative	[9]
Malonate sodium	DMAJDU7	Discovery agent	N.A.	Investigative	[7]
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide	DMNQDLC	Discovery agent	N.A.	Investigative	[18]
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide	DMA21WB	Discovery agent	N.A.	Investigative	[18]
N-(5-Sulfamoyl-[1,3,4]thiadiazol-2-yl)-benzamide	DMDZ9BY	Discovery agent	N.A.	Investigative	[12]
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide	DM5E7OC	Discovery agent	N.A.	Investigative	[18]
N-(phosphonacetyl)-L-aspartate	DMGHQJ8	Discovery agent	N.A.	Investigative	[13]
N-1,3,4-thiadiazol-2-ylsulfamide	DMJ10WH	Discovery agent	N.A.	Investigative	[18]
N-hydroxysulfonamides	DMJBC03	Discovery agent	N.A.	Investigative	[19]
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide	DMSI4PE	Discovery agent	N.A.	Investigative	[18]
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide	DMXLJGR	Discovery agent	N.A.	Investigative	[18]
N1-(naphthalen-1-yl)ethane-1,2-diamine	DMYGCSV	Discovery agent	N.A.	Investigative	[9]
Octane-1,8-diyl disulfamate	DMBQMGH	Discovery agent	N.A.	Investigative	[17]
Octyl sulfamate	DM40ZCA	Discovery agent	N.A.	Investigative	[17]
P-Coumaric Acid	DMGJSVD	Discovery agent	N.A.	Investigative	[5]
Pentane-1,5-diamine	DMVPZG9	Discovery agent	N.A.	Investigative	[9]
Phenyl Boronic acid	DMFZH49	Discovery agent	N.A.	Investigative	[20]
Phenyl-phosphonic acid	DMYMNBL	Discovery agent	N.A.	Investigative	[13]
Phenylarsonic acid	DMFRA1Y	Discovery agent	N.A.	Investigative	[21]
SODIUM CITRATE	DMHPD2Y	Common cold	CA00	Investigative	[7]
Sodium phenylarsonate	DMXELBI	Discovery agent	N.A.	Investigative	[20]
SODIUM PHOSPHATE, DIBASIC, ANHYDROUS	DM1G4S9	Discovery agent	N.A.	Investigative	[15]
Sodium sulfamate	DMAMV6T	Discovery agent	N.A.	Investigative	[20]
Sodium trithiocarbonate	DM6WYGC	Discovery agent	N.A.	Investigative	[22]
SULFAMATE	DMF1589	Discovery agent	N.A.	Investigative	[21]
SYL-040003	DM7YB08	Ocular hypertension	9C61.01	Investigative	[23]
Syringic Acid	DM802V7	Discovery agent	N.A.	Investigative	[5]
Trecadrine	DMDX0VI	Discovery agent	N.A.	Investigative	[24]
Trisodium phosphate	DMPVI3A	Discovery agent	N.A.	Investigative	[15]
[Cu(CN)2]-	DMV6NP1	Discovery agent	N.A.	Investigative	[25]
[Fe(CN)6]4-	DMWGADP	Discovery agent	N.A.	Investigative	[25]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [2] Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
• [3] Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54.
• [4] Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
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• [6] Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
• [7] Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):573-8.
• [8] Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.
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• [10] N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20.
• [11] Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44.
• [12] Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties. J Med Chem. 2002 Jan 17;45(2):312-20.
• [13] Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6.
• [14] Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide. Bioorg Med Chem Lett. 2003 Sep 1;13(17):2867-73.
• [15] Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral dru... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5763-7.
• [16] Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a l... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81.
• [17] Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8.
• [18] Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5.
• [19] Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with N-hydroxysulfonamides--a novel class of intraocular pressure lowering agents. J Enzyme Inhib. 1998 Jul;13(4):267-84.
• [20] Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1155-8.
• [21] Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73.
• [22] Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1855-7.
• [23] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2599).
• [24] Sulfenamido-sulfonamides as inhibitors of carbonic anhydrase isozymes I, II and IV. J Enzyme Inhib. 1997 Aug;12(3):175-90.
• [25] Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1909-13.