Drug Information

Drug General Information
Drug ID
D02ESK
Former ID
DIB000654
Drug Name
GSK-732461
Synonyms
HIV vaccine (gag, pol, nef), GSK; HIV vaccine (gag, pol, nef), GlaxoSmithKline; 732461; 732462
Drug Type
Vaccine
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Discontinued in Phase 2 [548656]
Company
GlaxoSmithKline plc
Target and Pathway
Target(s) HIV GAG protein Target Info [549839]
Negative factor Target Info [549839]
Reactome Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
2-LTR circle formation
Binding and entry of HIV virion
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
Integration of viral DNA into host genomic DNA
Autointegration results in viral DNA circles
APOBEC3G mediated resistance to HIV-1 infection
Vpr-mediated nuclear import of PICs
WikiPathways Host Interactions of HIV factors
HIV Life Cycle
References
Ref 548656Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027409)
Ref 549839Preventive technologies, research toward a cure, and immune-based and gene therapies. HIV Treatment Bulletin. 30 June 2013.